Development of hormone-dependent salivary cancer therapy based on the comprehensive understanding of androgen receptor
| Project/Area Number |
16K19090
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Human pathology
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| Research Institution | Fujita Health University |
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Principal Investigator |
Sakurai Kouhei 藤田保健衛生大学, 医学部, 助教 (10608756)
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| Project Period (FY) |
2016-04-01 – 2018-03-31
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| Project Status |
Completed (Fiscal Year 2017)
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| Budget Amount *help |
¥4,030,000 (Direct Cost: ¥3,100,000、Indirect Cost: ¥930,000)
Fiscal Year 2017: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2016: ¥2,470,000 (Direct Cost: ¥1,900,000、Indirect Cost: ¥570,000)
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| Keywords | 唾液腺導管癌 / 転写因子 / FOXA1 / マイクロアレイ / アンドロゲン受容体 / 転写制御 / mRNA / 唾液腺腫瘍 / 病理学 / 分子生物学 |
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| Outline of Final Research Achievements |
The purpose of this study is to reveal the molecular pathogenesis of salivary duct carcinoma (SDC). SDC, an androgen receptor (AR)-positive malignancy, is a relatively rare salivary cancer characterized by extremely poor outcome. The growth of SDC is reported to be androgen dependent. Although androgen deprivation therapy (ADT) might be effective in SDC based on its effect on other AR-expressing cancers, such as prostate cancer (PCa) and apocrine carcinoma of the breast (ACB), its detailed gene expression signature in SDC is unclear. In this study we compare the gene expressions of SDC, PCa and ACB to reveal their shared and distinct features. We aim to identify novel diagnostic marker and develop therapeutic strategy for SDC.
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Report
(3 results)
Research Products
(15 results)
