Clinicopathological significance of PD-L1 expression in peripheral T-cell lymphoma

• Project/Area Number: 16K19093
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Multi-year Fund
• Research Field: Human pathology
• Research Institution: Kurume University
• Principal Investigator: Miyoshi Hiroaki 久留米大学, 医学部, 講師 (30647780)
• Project Period (FY): 2016-04-01 – 2018-03-31
• Project Status: Completed (Fiscal Year 2017)
• Budget Amount: ¥3,380,000 (Direct Cost: ¥2,600,000、Indirect Cost: ¥780,000); Fiscal Year 2017: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000); Fiscal Year 2016: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
• Keywords: 悪性リンパ腫 / PD-L1 / 腫瘍免疫 / 予後 / ATLL / tumor-immunity / prognosis / 病理学 / 末梢性T細胞性リンパ腫 / 医歯薬学 / 基礎医学 / 人体病理学 / 血液

Outline of Final Research Achievements

Programmed cell death ligand 1 (PD-L1) is expressed on both tumor cells and tumor-infiltrating nonmalignant cells in lymphoid malignancies. The PD-1/PD-L1 pathway suppresses host antitumor responses, although little is known about the significance of PD-1/PD-L1 expression in the tumor microenvironment. To investigate the clinicopathological impact of PD-L1 expression in adult T-cell leukemia/ lymphoma(ATLL), we performed PD-L1 immunostaining. Neoplastic PD-L1 (nPD-L1) positive ATLL had inferior overall survival(OS) compared to nPD-L1 negative ATLL. Among nPD-L1 negative ATLL, microenvironmental PD-L1(miPD-L1) positive ATLL showed superior OS compared to PD-L1 negative ATLL. The expression of nPD-L1 and miPD-L1 maintained prognostic value for OS in multivariate analysis.
This is the significant report describing the clinicopathological features and outcomes of PD-L1 expression in ATLL.

Research Products

• [Journal Article] Expression pattern of immunosurveillance-related antigen in adult T cell leukaemia/lymphoma. (2018)
  • Author(s): Asano N, Miyoshi H, Kato T, Shimono J, Yoshida N, Kurita D, Sasaki Y, Kawamoto K, Ohshima K, Seto M.
  • Journal Title: Histopathology. Volume: 72 Issue: 6 Pages: 945-954
  • DOI: 10.1111/his.13461
  • Peer Reviewed
• [Journal Article] Epidemiology of malignant lymphoma and recent progress in research on adult T-cell leukemia/lymphoma in Japan. (2018)
  • Author(s): Miyoshi H, Ohshima K.
  • Journal Title: Int J Hematol. Volume: 107 Issue: 4 Pages: 420-427
  • DOI: 10.1007/s12185-018-2430-6
  • Peer Reviewed
• [Journal Article] Expression of programmed death ligand 1 is associated with poor prognosis in myeloid sarcoma patients. (2018)
  • Author(s): Kawamoto K, Miyoshi H, Suzuki T, Kiyasu J, Yokoyama S, Sasaki Y, Sone H, Seto M, Takizawa J, Ohshima K.
  • Journal Title: Hematol Oncol. Volume: Epub ahead of print Issue: 3 Pages: 591-599
  • DOI: 10.1002/hon.2506
  • Peer Reviewed
• [Journal Article] Frequent expression of CD30 in extranodal NK/T-cell lymphoma: Potential therapeutic target for anti-CD30 antibody-based therapy. (2018)
  • Author(s): Kawamoto K, Miyoshi H, Suzuki T, Sasaki Y, Yamada K, Yanagida E, Muto R, Kiryu M, Sone H, Seto M, Ohshima K, Takizawa J.
  • Journal Title: Hematol Oncol. Volume: 36 Issue: 1 Pages: 166-173
  • DOI: 10.1002/hon.2482
  • Peer Reviewed
• [Journal Article] Clinicopathological analysis in PTCL-NOS with CADM1 expression. (2017)
  • Author(s): Kato T, Miyoshi H, Kobayashi S, Yoshida N, Imaizumi Y, Seto M, Uchimaru K, Miyazaki Y, Ohshima K.
  • Journal Title: Virchows Arch. Volume: 471 Issue: 5 Pages: 659-666
  • DOI: 10.1007/s00428-017-2233-9
  • Peer Reviewed
• [Journal Article] Comparison of clinicopathological characteristics between T-cell prolymphocytic leukemia and peripheral T-cell lymphoma, not otherwise specified. (2017)
  • Author(s): Kawamoto K, Miyoshi H, Yanagida E, Yoshida N, Kiyasu J, Kozai Y, Morikita T, Kato T, Suzushima H, Tamura S, Muta T, Kato K, Eto T, Seki R, Nagafuji K, Sone H, Takizawa J, Seto M, Ohshima K.
  • Journal Title: Eur J Haematol. Volume: 98 Issue: 5 Pages: 459-466
  • DOI: 10.1111/ejh.12856
  • Peer Reviewed
• [Journal Article] A distinct subtype of Epstein Barr virus positive T/NK-cell lymphoproliferative disorder: Adult patients with chronic active Epstein Barr virus infection-like features. (2017)
  • Author(s): Kawamoto K, Miyoshi H, Suzuki T, Kozai Y, Kato K, Miyahara M, Yujiri T, Choi I, Fujimaki K, Muta T, Kume M, Moriguchi S, Tamura S, Kato T, Tagawa H, Makiyama J, Kanisawa Y, Sasaki Y, Kurita D, Yamada K, Shimono J, Sone H, Takizawa J, Seto M, Kimura H, Ohshima K.
  • Journal Title: Haematologica. Volume: Epub Issue: 6 Pages: 1018-1028
  • DOI: 10.3324/haematol.2017.174177
  • Peer Reviewed / Open Access
• [Journal Article] PD-L1 expression on neoplastic or stromal cell is respectively poor or good prognostic factor for adult T-cell leukemia/lymphoma. (2016)
  • Author(s): Miyoshi H, Kiyasu J, Kato T, Yoshida N, Shimono J, Yokoyama S, Taniguchi H, Sasaki Y, Kurita D, Kawamoto K, Kato K, Imaizumi Y, Seto M, Ohshima K.
  • Journal Title: Blood. Volume: 128 Issue: 10 Pages: 1374-1381
  • DOI: 10.1182/blood-2016-02-698936
  • Peer Reviewed / Open Access
• [Presentation] PD-L1 Expression on Neoplastic or Stromal Cell is Respectively Poor or Good Prognostic Factor for ATLL (2017)
  • Author(s): Hiroaki Miyoshi, Junichi Kiyasu, Takeharu Kato, Noriaki Yoshida, Joji Shimono, Shintaro Yokoyama, Hiroaki Taniguchi, Yuya Sasaki, Daisuke Kurita, Keisuke Kawamoto, Koji Kato, Yoshitaka Imaizumi, Masao Seto, Koichi Ohshima
  • Organizer: the 18th International Conference on Human Retrovirology: HTLV.
  • Place of Presentation: ホテルグランドアーク半蔵門 (東京)
  • Year and Date: 2017-03-07
  • Int'l Joint Research
• [Presentation] PD-L1 Expression on Neoplastic or Stromal Cell is Respectively Poor or Good Prognostic Factor for Adult T-cell Leukemia/ lymphoma (2017)
  • Author(s): Hiroaki Miyoshi, Junichi Kiyasu, Takeharu Kato, Noriaki Yoshida, Joji Shimono, Shintaro Yokoyama, Hiroaki Taniguchi, Yuya Sasaki, Daisuke Kurita, Keisuke Kawamoto, Koji Kato, Yoshitaka Imaizumi, Masao Seto, Koichi Ohshima
  • Organizer: T-cell lymphoma forum
  • Place of Presentation: サンフランシスコ（アメリカ合衆国）
  • Year and Date: 2017-01-26
  • Int'l Joint Research / Invited
• [Presentation] PD-L1 Expression on Neoplastic or Stromal Cell is Respectively Poor or Good Prognostic Factor for Adult T-cell Leukemia/ lymphoma (2017)
  • Author(s): Hiroaki Miyoshi, Junichi Kiyasu, Takeharu Kato, Noriaki Yoshida, Joji Shimono, Shintaro Yokoyama, Hiroaki Taniguchi, Yuya Sasaki, Daisuke Kurita, Keisuke Kawamoto, Koji Kato, Yoshitaka Imaizumi, Masao Seto, Koichi Ohshima
  • Organizer: 9th Annual T-cell lymphoma forum
  • Int'l Joint Research / Invited
• [Presentation] PD-L1 Expression on Neoplastic or Stromal Cell is Respectively Poor or Good Prognostic Factor for ATLL (2017)
  • Author(s): Hiroaki Miyoshi, Junichi Kiyasu, Takeharu Kato, Noriaki Yoshida, Joji Shimono, Shintaro Yokoyama, Hiroaki Taniguchi, Yuya Sasaki, Daisuke Kurita, Keisuke Kawamoto, Koji Kato, Yoshitaka Imaizumi, Masao Seto, Koichi Ohshima
  • Organizer: 18th International Conference on Human Retrovirology: HTLV.
  • Int'l Joint Research
• [Presentation] Investigation of biomarkers for neoplastic disease including malignant lymphoma. (2017)
  • Author(s): Hiroaki Miyoshi
  • Organizer: 第106回日本病理学会
  • Invited
• [Presentation] Investigation of biomarkers for neoplastic disease including malignant lymphoma. (2017)
  • Author(s): Hiroaki Miyoshi
  • Organizer: 第76回日本癌学会総会
  • Invited
• [Presentation] Investigation of biomarkers for neoplastic disease including malignant lymphoma. (2017)
  • Author(s): Miyoshi Hiroaki
  • Organizer: 第106会病理学会総会
  • Place of Presentation: 京王プラザホテル (東京)