| Project/Area Number |
16K19094
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Human pathology
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| Research Institution | Kurume University |
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Principal Investigator |
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| Research Collaborator |
YANO Hirohisa
AKIBA Jun
NAITO Yoshiki
KUSANO Hironori
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| Project Period (FY) |
2016-04-01 – 2018-03-31
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| Project Status |
Completed (Fiscal Year 2017)
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| Budget Amount *help |
¥2,600,000 (Direct Cost: ¥2,000,000、Indirect Cost: ¥600,000)
Fiscal Year 2017: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000)
Fiscal Year 2016: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
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| Keywords | C型肝炎 / SVR / 肝がん / 線維化 / 病理学 |
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| Outline of Final Research Achievements |
Sustained virological response (SVR) is defined as undetectable serum hepatitis C virus (HCV) RNA after completion of antiviral therapy for chronic HCV infection. We studied resected liver tissues in 53 patients with initial hepatocellular carcinoma (HCC) after achieving SVR. This study found following insights. (1) Hepatic fibrosis that does not decrease sufficiently after achieving SVR may be a risk factor of liver carcinogenesis in the patients after achieving SVR. Sinusoidal capillarization, i.e., CD34 expression in sinusoidal mesenchymal cells, and activation of HSCs, i.e., αSMA expression in sinusoidal mesenchymal cells, may contribute to hepatic fibrosis after achieving SVR. (2) There were 14 patients with previous infection of hepatitis B virus.
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