| Project/Area Number |
16K19095
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Human pathology
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| Research Institution | Kurume University |
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Principal Investigator |
Sasaki Yuya 久留米大学, 医学部, 助教 (50750725)
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| Project Period (FY) |
2016-04-01 – 2018-03-31
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| Project Status |
Completed (Fiscal Year 2017)
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| Budget Amount *help |
¥3,380,000 (Direct Cost: ¥2,600,000、Indirect Cost: ¥780,000)
Fiscal Year 2017: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2016: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
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| Keywords | 悪性リンパ腫 / 白血病 / 多発性骨髄腫 / 骨髄増殖性疾患 / 骨髄異形成症候群 / エストロゲンレセプター / 性ホルモン / エストロゲン受容体 / 細胞周期 / 性ホルモン受容体 / エストロゲン / びまん性大細胞型B細胞リンパ腫 / 造血器腫瘍 |
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| Outline of Final Research Achievements |
We clinically and pathologically analyzed the expression rate of estrogen receptor alpha and estrogen receptor beta, mainly for diffuse large cell type B cell lymphoma (DLBCL). Furthermore, we analyzed the effect of an estrogen receptor inhibitor on cultured cells derived from DLBCL. As a result, we obtained the result of the effect of the drug, involved in cell cycle arrest through the MAP kinase pathway. This result may lead to new therapeutic development.
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