The role of sexual hormone in hematological malignancies

• Project/Area Number: 16K19095
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Multi-year Fund
• Research Field: Human pathology
• Research Institution: Kurume University
• Principal Investigator: Sasaki Yuya 久留米大学, 医学部, 助教 (50750725)
• Project Period (FY): 2016-04-01 – 2018-03-31
• Project Status: Completed (Fiscal Year 2017)
• Budget Amount: ¥3,380,000 (Direct Cost: ¥2,600,000、Indirect Cost: ¥780,000); Fiscal Year 2017: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000); Fiscal Year 2016: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
• Keywords: 悪性リンパ腫 / 白血病 / 多発性骨髄腫 / 骨髄増殖性疾患 / 骨髄異形成症候群 / エストロゲンレセプター / 性ホルモン / エストロゲン受容体 / 細胞周期 / 性ホルモン受容体 / エストロゲン / びまん性大細胞型B細胞リンパ腫 / 造血器腫瘍

Outline of Final Research Achievements

We clinically and pathologically analyzed the expression rate of estrogen receptor alpha and estrogen receptor beta, mainly for diffuse large cell type B cell lymphoma (DLBCL). Furthermore, we analyzed the effect of an estrogen receptor inhibitor on cultured cells derived from DLBCL. As a result, we obtained the result of the effect of the drug, involved in cell cycle arrest through the MAP kinase pathway. This result may lead to new therapeutic development.

Research Products

• [Journal Article] Expression of programmed death ligand 1 is associated with poor prognosis in myeloid sarcoma patients. (2018)
  • Author(s): Kawamoto K, Miyoshi H, Suzuki T, Kiyasu J, Yokoyama S, Sasaki Y, Sone H, Seto M, Takizawa J, Ohshima K.
  • Journal Title: Hematol Oncol. Volume: Epub ahead of print Issue: 3 Pages: 591-599
  • DOI: 10.1002/hon.2506
  • Peer Reviewed
• [Journal Article] The Emerging Impact of Social Media on Cancer Patient Education in Japan (2018)
  • Author(s): Sasaki Yuya、Ueno Naoto T.
  • Journal Title: The Oncologist Volume: Epub ahead of print Issue: 9 Pages: e105-e106
  • DOI: 10.1634/theoncologist.2017-0670
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Expression pattern of immunosurveillance-related antigen in adult T cell leukaemia/lymphoma. (2018)
  • Author(s): Asano N, Miyoshi H, Kato T, Shimono J, Yoshida N, Kurita D, Sasaki Y, Kawamoto K, Ohshima K, Seto M.
  • Journal Title: Histopathology. Volume: 72 Issue: 6 Pages: 945-954
  • DOI: 10.1111/his.13461
  • Peer Reviewed
• [Journal Article] Frequent expression of CD30 in extranodal NK/T-cell lymphoma: Potential therapeutic target for anti-CD30 antibody-based therapy. (2018)
  • Author(s): Kawamoto K, Miyoshi H, Suzuki T, Sasaki Y, Yamada K, Yanagida E, Muto R, Kiryu M, Sone H, Seto M, Ohshima K, Takizawa J.
  • Journal Title: Hematol Oncol. Volume: 36 Issue: 1 Pages: 166-173
  • DOI: 10.1002/hon.2482
  • Peer Reviewed
• [Journal Article] Prognostic factors for histiocytic and dendritic cell neoplasms (2017)
  • Author(s): Shimono Joji、Miyoshi Hiroaki、Arakawa Fumiko、Sato Kensaku、Furuta Takuya、Muto Reiji、Yanagida Eriko、Sasaki Yuya、Kurita Daisuke、Kawamoto Keisuke、Nagafuji Koji、Ohshima Koichi
  • Journal Title: Oncotarget Volume: 8 Issue: 58 Pages: 98723-98732
  • DOI: 10.18632/oncotarget.21920
  • Peer Reviewed / Open Access
• [Presentation] エストロゲンレセプターアルファ(ERα)を発現する DLBCL の臨床病理学的解析とDLBCL細胞株を用いたERαの機能解析 (2017)
  • Author(s): 佐々木裕哉、吉田 稚明、三好 寛明、河本 啓介、下埜城嗣、栗田大輔、瀬戸加大、大島孝一
  • Organizer: 第57回日本リンパ網内系学会総会
• [Presentation] Estrogen receptpr α(ERa)を発現するDLBCLの74例の臨床像解析とDLBCL細胞株 におけるERaの機能解析 (2017)
  • Author(s): 佐々木裕哉、吉田 稚明、三好 寛明、佐治重衡、河本 啓介、喜安純一、瀬戸加大、大島孝一
  • Organizer: 第79回日本血液学会学術集会
• [Presentation] びまん性大細胞型B細胞リンパ腫におけるエストロゲンレセプターアルファの発現 (2016)
  • Author(s): 佐々木裕哉 三好寛明 吉田稚明 中嶋一貴 佐治重衡 河本啓介 下埜城嗣 栗田大輔 瀬戸加大 大島孝一
  • Organizer: 第78回日本血液学会学術集会
  • Place of Presentation: パシフィコ横浜(神奈川県横浜市)
  • Year and Date: 2016-10-13
• [Patent(Industrial Property Rights)] 悪性リンパ腫に対するフルベストラントを用いた新規治療 (2016)
  • Inventor(s): 佐々木裕哉ら
  • Industrial Property Rights Holder: 佐々木裕哉ら
  • Industrial Property Rights Type: 特許
  • Filing Date: 2016-05-26