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Analysis of Japanese Prostate Cancer: Mutation Analysis and Prediction of Pathway

Research Project

Project/Area Number 16K19099
Research Category

Grant-in-Aid for Young Scientists (B)

Allocation TypeMulti-year Fund
Research Field Human pathology
Research InstitutionKanagawa Cancer Center Research Institute

Principal Investigator

Rika Kasajima  地方独立行政法人神奈川県立病院機構神奈川県立がんセンター(臨床研究所), その他部局等, 特別研究員 (20630875)

Project Period (FY) 2016-04-01 – 2018-03-31
Project Status Completed (Fiscal Year 2017)
Budget Amount *help
¥4,030,000 (Direct Cost: ¥3,100,000、Indirect Cost: ¥930,000)
Fiscal Year 2017: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2016: ¥2,470,000 (Direct Cost: ¥1,900,000、Indirect Cost: ¥570,000)
Keywords次世代シークエンサー / Ion PGM / 遺伝子変異解析 / 前立腺癌 / ネットワーク解析 / 遺伝子間ネットワーク解析 / ネットワーク / 泌尿生殖器・内分泌
Outline of Final Research Achievements

There exist many integrated analyses of whole-genome, exome, and transcriptome data of Caucasian prostate cancer. However, a few reports of analysis on Japanese cases have been available in literature. It has been known that there are “regional and/or ethnic differences” between Asian and Caucasian populations in the tumorigenesis of prostate cancer.
To detect the genetic alterations appeared in prostate cancer in Japanese population, we created new panels designated as KCC71. In KCC71, 71 genes were selected, based on the gene mutations reported in the analyses of prostate cancers. In this study, frozen tumor tissues from 21 Japanese prostate cancer patients were subjected to the analyses with the panels using Ion PGM to identify gene alterations.
We found that some genes had highly frequent genetic mutations. We also performed pathway analyses to predict the molecular pathways related to prostate cancer tumorigenesis in Japanese population with TNCG data base.

Report

(3 results)
  • 2017 Annual Research Report   Final Research Report ( PDF )
  • 2016 Research-status Report
  • Research Products

    (2 results)

All 2017 2016

All Presentation (2 results)

  • [Presentation] 日本人における前立腺癌の遺伝子変異解析と癌化経路の予測2017

    • Author(s)
      笠島理加
    • Organizer
      NGS現場の会 第五回研究会
    • Related Report
      2017 Annual Research Report
  • [Presentation] Analysis of Japanese Prostate Cancer: Mutation analysis and Prediction of Pathway2016

    • Author(s)
      笠島理加
    • Organizer
      第75回日本癌学会学術総会
    • Place of Presentation
      パシフィコ横浜
    • Year and Date
      2016-10-06
    • Related Report
      2016 Research-status Report

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Published: 2016-04-21   Modified: 2019-03-29  

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