| Project/Area Number |
16K19100
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Experimental pathology
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| Research Institution | University of Tsukuba |
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Principal Investigator |
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| Research Collaborator |
Meidi Utami Puteri
Riezki Amalia
Mohammed Abdelaziz
Bantari Wisynu Kusuma Wardhani
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| Project Period (FY) |
2016-04-01 – 2018-03-31
|
| Project Status |
Completed (Fiscal Year 2017)
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| Budget Amount *help |
¥4,030,000 (Direct Cost: ¥3,100,000、Indirect Cost: ¥930,000)
Fiscal Year 2017: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Fiscal Year 2016: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
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| Keywords | 腫瘍形成 / 足場非依存的増殖 / TMEPAI / Wnt / がん関連遺伝子 / 生体内機能解析 / 腫瘍学 / 実験病理学 |
|---|
| Outline of Final Research Achievements |
TMEPAI is a transmembrane protein that is highly expressed in cancer cells and is known to be involved in tumorigenesis. Several TMEPAI isoforms that possess distinct extra-cellular domain are reported. In this study, we found that the TMEPAI isoform D is strongly expressed in breast cancer cell lines. Therefore, TMEPAI in involved in anchorage-independent growth in breast cancer cells. Moreover, we demonstrated that TMEPAI's novel molecular function that TMEPAI inhibits Wnt signaling pathway.
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