The molecular function of TMEPAI in tumorigenesis
| Project/Area Number |
16K19100
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Experimental pathology
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| Research Institution | University of Tsukuba |
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Principal Investigator |
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| Research Collaborator |
Meidi Utami Puteri
Riezki Amalia
Mohammed Abdelaziz
Bantari Wisynu Kusuma Wardhani
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| Project Period (FY) |
2016-04-01 – 2018-03-31
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| Project Status |
Completed (Fiscal Year 2017)
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| Budget Amount *help |
¥4,030,000 (Direct Cost: ¥3,100,000、Indirect Cost: ¥930,000)
Fiscal Year 2017: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Fiscal Year 2016: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
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| Keywords | 腫瘍形成 / 足場非依存的増殖 / TMEPAI / Wnt / がん関連遺伝子 / 生体内機能解析 / 腫瘍学 / 実験病理学 |
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| Outline of Final Research Achievements |
TMEPAI is a transmembrane protein that is highly expressed in cancer cells and is known to be involved in tumorigenesis. Several TMEPAI isoforms that possess distinct extra-cellular domain are reported. In this study, we found that the TMEPAI isoform D is strongly expressed in breast cancer cell lines. Therefore, TMEPAI in involved in anchorage-independent growth in breast cancer cells. Moreover, we demonstrated that TMEPAI's novel molecular function that TMEPAI inhibits Wnt signaling pathway.
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Report
(3 results)
Research Products
(7 results)
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[Journal Article] The protein kinase LKB1 negatively regulates bone morphogenetic protein receptor signaling.2016
Author(s)
Raja E, Tzavlaki K, Vuilleumier R, Edlund K, Kahata K, Zieba A, Moren A, Watanabe Y, Voytruk I, Botling J, Soderberg O, Micke P, Pyrowolakis G, Heldin C-H, Moustakas A
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Journal Title
Oncotarget
Volume: 7
Issue: 2
Pages: 1120-1143
DOI
Related Report
Peer Reviewed / Open Access / Int'l Joint Research
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