| Budget Amount *help |
¥3,770,000 (Direct Cost: ¥2,900,000、Indirect Cost: ¥870,000)
Fiscal Year 2019: ¥780,000 (Direct Cost: ¥600,000、Indirect Cost: ¥180,000)
Fiscal Year 2018: ¥780,000 (Direct Cost: ¥600,000、Indirect Cost: ¥180,000)
Fiscal Year 2017: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2016: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
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| Outline of Final Research Achievements |
Endthelial to mesenchymal transition (EndMT) is defined as the acquisition of mesenchymal characteristics by the endothelium. It has been implicated in pathogenesis and progression of pulmonary arterial hypertension (PAH).
Exposure to Sugen/Hypoxia induced cell proliferation and expression of progenitor cell markers such as CD133 in pulmonary vascular endothelial cells (PVECs) . Moreover, partial EndMT cells (SMA+/CD31+CD45-) were significantly increased in this model compared with hypoxic mice, although complete EndMT cells which lose characteristics of PVECs were confirmed equally in both models. The partial EndMT cells represent feature of progenitor cells prominently. These cells could contribute to the pathogenesis of PAH, especially in intimal lesion.
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