| Project/Area Number |
16K19113
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Parasitology (including sanitary zoology)
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| Research Institution | Hokkaido University |
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Principal Investigator |
Okubo Torahiko 北海道大学, 保健科学研究院, 講師 (90762196)
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| Co-Investigator(Renkei-kenkyūsha) |
YAMAGUCHI Hiroyuki 北海道大学, 大学院保健科学研究院, 教授 (40221650)
MATSUO Junji 北海道大学, 大学院保健科学研究院, 講師 (50359486)
NAKAMURA Shinji 順天堂大学, 医学研究科, 助教 (40207882)
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| Research Collaborator |
MATSUSHITA Mizue
AKIZAWA Kouji
HAYASAKA Kasumi
FUKUMOTO Tatsuya
IWASAKI Sumio
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| Project Period (FY) |
2016-04-01 – 2018-03-31
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| Project Status |
Completed (Fiscal Year 2017)
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| Budget Amount *help |
¥2,990,000 (Direct Cost: ¥2,300,000、Indirect Cost: ¥690,000)
Fiscal Year 2017: ¥780,000 (Direct Cost: ¥600,000、Indirect Cost: ¥180,000)
Fiscal Year 2016: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
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| Keywords | 微生物間相互作用 / 薬剤耐性菌 / 原生生物 / クオラムセンシング / 微生物 |
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| Outline of Final Research Achievements |
AI-2 is a bacterial signal molecule which is used for bacterial closs talk. In our previous studies, we reported that co-cultivation of bacteria and protozoa causes the raise of AI-2 concentration in the solution. However, the effect of AI-2 on protozoa was not reported. In this study, we compared phenotypic characteristics of protozoa under the presence or absence of AI-2. Our results showed that AI-2 causes the raise of mobility of amoeba cells in a concentraion dependent manner on solid agar surfaces. This suggests that amoeba can detect AI-2 concentration and control its mobility. We showed cross-Kingdom effect of AI-2 on protozoa for the first time.
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