Elucidation of the function of group 2 innate lymphoid cells in chronic and severe cases of amebiasis
| Project/Area Number |
16K19118
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Parasitology (including sanitary zoology)
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| Research Institution | Nagasaki University |
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Principal Investigator |
NAKAMURA Risa 長崎大学, 熱帯医学研究所, 助教 (50645801)
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| Project Period (FY) |
2016-04-01 – 2018-03-31
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| Project Status |
Completed (Fiscal Year 2017)
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| Budget Amount *help |
¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000)
Fiscal Year 2017: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Fiscal Year 2016: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
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| Keywords | 赤痢アメーバ症 / グループ２自然リンパ球 / Th2サイトカイン / 寄生虫感染症 / 免疫学 / 腸赤痢アメーバ症 / 感染症 / 寄生虫 / Th2 サイトカイン |
|---|
| Outline of Final Research Achievements |
Intestinal amebiasis is chronic and presents severe symptoms such as liver abscess and brain abscess. Preventing the chronic infection of Entamoeba histolytica is important in host defense against severe pathological conditions. It has been reported that intestinal infection of Entamoeba histolytica produces a large amount of Th2 cytokines from the early phase of infection, but its role in the source and pathogenesis and severity has not been clarified. In this study, we found that the source of Th2 cytokines early in infection with Entamoeba histolytica is group 2 innate lymphoid cells (ILC2). Furthermore, the in vivo depletion of ILC2 revealed that ILC2 and its Th2 cytokines contribute to exacerbating the pathogenesis of amebiasis.
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Report
(3 results)
Research Products
(20 results)
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[Journal Article] Schistosoma mansoni infection suppresses the growth of Plasmodium yoelii parasites in the liver and reduces gametocyte infectivity to mosquitoes.2018
Author(s)
Moriyasu, T., Nakamura, R., Deloer, S., Senba, M., Kubo, M., Inoue, M., Culleton, R., Hamano, S.
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Journal Title
PLoS Negl. Trop. Dis. e0006197.
Volume: 12
Issue: 1
Pages: e0006197-e0006197
DOI
Related Report
Peer Reviewed / Open Access / Int'l Joint Research
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[Journal Article] IL-17A contributes to reducing IFN-gamma/IL-4 ratio and persistence of Entamoeba histolytica during intestinal amebiasis2017
Author(s)
Deloer, S. Nakamura, R. Kikuchi, M. Moriyasu, T. Kalenda, Y. D. J. Mohammed, E. S. Senba, M. Iwakura, Y. Yoshida, H. Hamano, S.
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Journal Title
Parasitol Int
Volume: 66
Issue: 6
Pages: 817-823
DOI
Related Report
Peer Reviewed / Open Access / Int'l Joint Research
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[Journal Article] Spatial distribution and risk factors of Schistosoma haematobium and hookworm infections among schoolchildren in Kwale, Kenya.2017
Author(s)
Chadeka EA, Nagi S, Sunahara T, Cheruiyot NB, Bahati F, Ozeki Y, Inoue M, Osada-Oka M, Okabe M, Hirayama Y, Changoma M, Adachi K, Mwende F, Kikuchi M, Nakamura R, Kalenda YDJ, Kaneko S, Hirayama K, Shimada M, Ichinose Y, Njenga SM, Matsumoto S, Hamano S.
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Journal Title
PLoS Negl Trop Dis
Volume: 11
Issue: 9
Pages: e0005872-e0005872
DOI
NAID
Related Report
Peer Reviewed / Open Access / Int'l Joint Research
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