Study on the relationship between the causative Fusarium species of invasive fusariosis and environmental fungal flora
| Project/Area Number |
16K19120
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Bacteriology (including mycology)
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| Research Institution | Chiba University |
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Principal Investigator |
Muraosa Yasunori 千葉大学, 真菌医学研究センター, 特任助教 (10574668)
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| Research Collaborator |
Oguchi Misato
Hino Yutaro
Yahiro Maki
Yarita kyoko
Watanabe Akira
Kamei Katsuhiko
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| Project Period (FY) |
2016-04-01 – 2019-03-31
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| Project Status |
Completed (Fiscal Year 2018)
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| Budget Amount *help |
¥4,030,000 (Direct Cost: ¥3,100,000、Indirect Cost: ¥930,000)
Fiscal Year 2018: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2017: ¥780,000 (Direct Cost: ¥600,000、Indirect Cost: ¥180,000)
Fiscal Year 2016: ¥2,340,000 (Direct Cost: ¥1,800,000、Indirect Cost: ¥540,000)
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| Keywords | Fusarium / FSSC / 病原真菌 / 環境調査 / メタゲノム解析 / メタゲノム |
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| Outline of Final Research Achievements |
The objective of this study is to reveal the relationship between the causative Fusarium species of invasive fusariosis and environmental fungal flora and the difference of virulence. F. petroliphilum (a member of the FSSC) was predominately isolated from the patients with invasive fusariosis. It was reveals that F. petroliphilum predominately isolated from the drain ports in the room. In the infection experiments using mice, the weight loss rate at 7 days after infection in the F. petroliphilum infection group was significantly reduced compared to the F. falciforme and the F. oxysporum infection groups. In addition to environmental factors, it was suggested that the virulence of F. petroliphilum was somewhat involved in the development of invasive fusariosis.
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| Academic Significance and Societal Importance of the Research Achievements |
本邦ではこれまでにフザリウム症原因菌の詳細については調査されてこなかった。本研究ではフザリウム症の原因菌の詳細を明らかにし、本症の新たな基礎知見の集積に貢献した。さらに病室を含む室内の排水口が深在性フザリウム症の感染源として強く疑われることを示した。深在性フザリウム症の多くは病室内での感染が疑われることから、本研究の成果は今後の深在性フザリウム症の感染防除対策に深く寄与するものと考えられる。
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Report
(4 results)
Research Products
(15 results)
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[Journal Article] Airborne transmission of invasive fusariosis in patients with hematologic malignancies2018
Author(s)
Moretti Maria Luiza、Busso-Lopes Ariane Fidelis、Tararam Cibele Aparecida、Moraes Renato、Muraosa Yasunori、Mikami Yuzuru、Gonoi Tohru、Taguchi Hideaki、Lyra Luzia、Reichert-Lima Franqueline、Trabasso Plinio、de Hoog Gerrit Sybren、Al-Hatmi Abdullah Mohammed Said、Schreiber Angelica Zaninelli、Kamei Katsuhiko
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Journal Title
PLOS ONE
Volume: 13
Issue: 4
Pages: e0196426-e0196426
DOI
Related Report
Peer Reviewed / Open Access / Int'l Joint Research
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[Journal Article] Successful Combination Therapy of Liposomal Amphotericin B and Caspofungin for Disseminated Fusariosis in a Pediatric Patient with Acute Lymphoblastic Leukemia2018
Author(s)
Uemura S, Tamura A, Yamamoto N, Saito A, Nakamura S, Fujiwara T, Tahara T, Kozaki A, Kishimoto K, Ishida T, Hasegawa D, Muraosa Y, Kamei K, Kosaka Y
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Journal Title
Pediatr Infect Dis J.
Volume: 印刷中
Issue: 10
Pages: e251-e253
DOI
Related Report
Peer Reviewed
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