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Functional analysis of a bacterial contributor to coughing fits in whooping cough

Research Project

Project/Area Number 16K19124
Research Category

Grant-in-Aid for Young Scientists (B)

Allocation TypeMulti-year Fund
Research Field Bacteriology (including mycology)
Research InstitutionKyushu University

Principal Investigator

Nakamura Keiji  九州大学, 医学研究院, 学術研究員 (60706216)

Project Period (FY) 2016-04-01 – 2018-03-31
Project Status Completed (Fiscal Year 2017)
Budget Amount *help
¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000)
Fiscal Year 2017: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Fiscal Year 2016: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Keywords百日咳 / 発作性咳嗽 / 気管支敗血症菌 / 実験動物モデル / 感染動物モデル
Outline of Final Research Achievements

Whooping cough (pertussis) is a highly contagious bacterial respiratory infection, which is characterized by coughing of infected hosts. The causative agents and mechanism of the coughing remain unknown. In the present study, the gene cx (Cough X, a tentative name), which was newly found as one of bacterial factors associated with the coughing, was characterized. The coughing animal models with living bacteria or bacterial lysates indicated that the protein CX, which is the cx gene transcript, probably regulate expression of unknown bacterial causative agents in infected hosts. Moreover, these models revealed that another known bacterial regulator also controls the expression of the agents during in vitro culture. Several candidates causing the coughing were found by searching the downstream genes of the two regulators with the coughing animal models. Further analysis about these candidates potentially leads to identify the genuine bacterial coughing factors.

Report

(3 results)
  • 2017 Annual Research Report   Final Research Report ( PDF )
  • 2016 Research-status Report
  • Research Products

    (4 results)

All 2018 2017

All Journal Article (1 results) (of which Peer Reviewed: 1 results) Presentation (3 results)

  • [Journal Article] Protective effects of in vivo-expressed autotransporters against Bordetella pertussis infection2017

    • Author(s)
      Suzuki Koichiro、Shinzawa Naoaki、Ishigaki Keisuke、Nakamura Keiji、Abe Hiroyuki、Fukui-Miyazaki Aya、Ikuta Kazuyoshi、Horiguchi Yasuhiko
    • Journal Title

      Microbiology and Immunology

      Volume: 61 Issue: 9 Pages: 371-379

    • DOI

      10.1111/1348-0421.12504

    • NAID

      40021326030

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed
  • [Presentation] 気管支敗血症菌を用いたボルデテラ属細菌の発咳機構の解析2018

    • Author(s)
      篠田典子、中村佳司、神谷重樹、新澤直明、堀口安彦
    • Organizer
      人獣共通感染症研究拠点シンポジウム
    • Related Report
      2017 Annual Research Report
  • [Presentation] Screening for the Bordetella dermonecrotic toxin receptor2018

    • Author(s)
      照屋志帆乃、福井理、中村佳司、新澤直明、堀口安彦
    • Organizer
      第91回日本細菌学会総会
    • Related Report
      2017 Annual Research Report
  • [Presentation] ボルデテラ壊死毒(DNT)の細胞受容体同定2017

    • Author(s)
      照屋志帆乃、福井理、中村佳司、新澤直明、堀口安彦
    • Organizer
      第70回日本細菌学会関西支部総会
    • Related Report
      2017 Annual Research Report

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Published: 2016-04-21   Modified: 2019-03-29  

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