The mechanisms by which polyI:C enhances IgA production in NALT
| Project/Area Number |
16K19134
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Virology
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| Research Institution | Hokkaido University |
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Principal Investigator |
Ariki Hiromi 北海道大学, 医学研究科, 助教 (40515061)
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| Project Period (FY) |
2016-04-01 – 2018-03-31
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| Project Status |
Completed (Fiscal Year 2017)
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| Budget Amount *help |
¥4,030,000 (Direct Cost: ¥3,100,000、Indirect Cost: ¥930,000)
Fiscal Year 2017: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2016: ¥2,470,000 (Direct Cost: ¥1,900,000、Indirect Cost: ¥570,000)
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| Keywords | TLR3 / polyI:C / CD103陽性樹状細胞 / 鼻腔関連リンパ組織 / NALT / 樹状細胞 / 粘膜免疫 / TICAM1 / インフルエンザワクチン / ウィルス / 免疫学 |
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| Outline of Final Research Achievements |
The development of influenza virus prevention vaccines requires the proper selection of appropriate adjuvants. The mechanism by which poly I: C promotes antibody production has not been fully elucidated. PolyI:C is a synthetic analog for double-stranded RNA and intranasal inoculation with polyI:C strongly enhances IgA production in nasal mucosa. To uncover the mechanisms by which intranasal inoculation with polyI:C enhances IgA production, I investigated immune responses in nasal-associated lymphoid tissue after intranasal vaccination.
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Report
(3 results)
Research Products
(10 results)
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[Journal Article] The anti-oxidant ergothioneine augments the immunomodulatory function of TLR agonists by direct action on macrophages.2017
Author(s)
Yoshida, S., Shime, H., Funami, K., Takaki, H., Tomiyama, T., Matsumoto, M., Kasahara, M. and Seya, T.
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Journal Title
PLoS ONE
Volume: 12
Issue: 1
Pages: e0169360-e0169360
DOI
NAID
Related Report
Peer Reviewed / Open Access
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