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Molecular Mechanisms a Novel Genotype of Respiratory Syncytial Virus Replaced Old One

Research Project

Project/Area Number 16K19135
Research Category

Grant-in-Aid for Young Scientists (B)

Allocation TypeMulti-year Fund
Research Field Virology
Research InstitutionKyoto University (2017)
Tohoku University (2016)

Principal Investigator

Furuse Yuki  京都大学, ウイルス・再生医科学研究所, 特定助教 (50740940)

Research Collaborator Oshitnai Hitoshi  
Okamoto Michiko  
Project Period (FY) 2016-04-01 – 2018-03-31
Project Status Completed (Fiscal Year 2017)
Budget Amount *help
¥4,030,000 (Direct Cost: ¥3,100,000、Indirect Cost: ¥930,000)
Fiscal Year 2017: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Fiscal Year 2016: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
KeywordsRSウイルス / 感染症 / 呼吸器感染 / 進化 / 遺伝子 / ウイルス / 病原性 / ウィルス / 微生物
Outline of Final Research Achievements

Respiratory syncytial virus (RSV) is a major cause of bronchiolitis among young children. In the study project, we analyzed a new genotype of the virus, ON1. We identified genetic signature of the ON1 RSV by whole genome sequencing. Phylogenetic analysis with the sequence data revealed evolutionary pathway that the ON1 RSV had generated. Mathematical modelling found immunological difference and seasonality as factors responsible for replacement of circulating genotypes of the virus. We also found a phenotypic difference between the ON1 and a former genotype of the virus in infection model with isolated virus and human airway-derived cells. Further study would unveil molecular mechanisms underlying difference between the genotypes.

Report

(3 results)
  • 2017 Annual Research Report   Final Research Report ( PDF )
  • 2016 Research-status Report
  • Research Products

    (4 results)

All 2018 Other

All Int'l Joint Research (1 results) Journal Article (2 results) (of which Int'l Joint Research: 1 results,  Peer Reviewed: 2 results,  Open Access: 1 results) Remarks (1 results)

  • [Int'l Joint Research] Research Institute for Tropical Medicine(フィリピン)

    • Related Report
      2017 Annual Research Report
  • [Journal Article] Multiple or Single Duplication Events Leading to the Emergence of a Novel Genotype of Respiratory Syncytial Virus.2018

    • Author(s)
      Furuse Y.
    • Journal Title

      Journal of Infectious Diseases

      Volume: NA Issue: 12 Pages: 2008-2010

    • DOI

      10.1093/infdis/jiy154

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Complete Genome Sequences of 13 Human Respiratory Syncytial Virus Subgroup A Strains of Genotypes NA1 and ON1 Isolated in the Philippines.2018

    • Author(s)
      Malasao R, Furuse Y, Okamoto M, Dapat C, Saito M, Saito-Obata M, Tamaki R, Segubre-Mercado E, Lupisan S, Oshitani H.
    • Journal Title

      Genome Announcements

      Volume: 6 Issue: 10 Pages: 10-10

    • DOI

      10.1128/genomea.00151-18

    • NAID

      120006466607

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Remarks] Yuki Furuse Lab

    • URL

      http://furuse-lab.strikingly.com/

    • Related Report
      2017 Annual Research Report

URL: 

Published: 2016-04-21   Modified: 2019-03-29  

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