| Project/Area Number |
16K19140
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Virology
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| Research Institution | Hiroshima University |
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Principal Investigator |
Oda Kosuke 広島大学, 医歯薬保健学研究科(医), 助教 (60571255)
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| Project Period (FY) |
2016-04-01 – 2018-03-31
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| Project Status |
Completed (Fiscal Year 2017)
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| Budget Amount *help |
¥4,030,000 (Direct Cost: ¥3,100,000、Indirect Cost: ¥930,000)
Fiscal Year 2017: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Fiscal Year 2016: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
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| Keywords | ハイスループットスクリーニング / FRET / 抗ウイルス薬 / センダイウイルス / Cタンパク質 / PPI阻害剤 / ヒトパラインフルエンザウイルス / PPI / パラミクソウイルス / 感染症 / 創薬 / X線結晶構造解析 / アクセサリータンパク質 |
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| Outline of Final Research Achievements |
Sendai virus (SeV) causes respiratory tract infection in mice and used as a prototype of viruses belonging to the family paramyxoviridae. In SeV lacking the C protein, the viral pathogenicity was significantly decreased. C protein associates with STAT1 to escape from the host innate system, and it associates with Alix for efficient viral budding from host cells. It is possible that a compound that inhibits the interaction between C protein and STAT1/Alix will become an antiviral drug against SeV or SeV-related viruses. In this study, we carried out a high-throughput screening assay to find a candidate agent targeting C protein. As the result, some acridone derivatives were found to inhibit the association of C protein with Alix.
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