Development of an anti-paramyxovirus drug targeting accessory C protein
| Project/Area Number |
16K19140
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Virology
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| Research Institution | Hiroshima University |
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Principal Investigator |
Oda Kosuke 広島大学, 医歯薬保健学研究科(医), 助教 (60571255)
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| Project Period (FY) |
2016-04-01 – 2018-03-31
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| Project Status |
Completed (Fiscal Year 2017)
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| Budget Amount *help |
¥4,030,000 (Direct Cost: ¥3,100,000、Indirect Cost: ¥930,000)
Fiscal Year 2017: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Fiscal Year 2016: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
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| Keywords | ハイスループットスクリーニング / FRET / 抗ウイルス薬 / センダイウイルス / Cタンパク質 / PPI阻害剤 / ヒトパラインフルエンザウイルス / PPI / パラミクソウイルス / 感染症 / 創薬 / X線結晶構造解析 / アクセサリータンパク質 |
|---|
| Outline of Final Research Achievements |
Sendai virus (SeV) causes respiratory tract infection in mice and used as a prototype of viruses belonging to the family paramyxoviridae. In SeV lacking the C protein, the viral pathogenicity was significantly decreased. C protein associates with STAT1 to escape from the host innate system, and it associates with Alix for efficient viral budding from host cells. It is possible that a compound that inhibits the interaction between C protein and STAT1/Alix will become an antiviral drug against SeV or SeV-related viruses. In this study, we carried out a high-throughput screening assay to find a candidate agent targeting C protein. As the result, some acridone derivatives were found to inhibit the association of C protein with Alix.
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Report
(3 results)
Research Products
(29 results)
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[Journal Article] Eligibility of feline calicivirus for a surrogate of human norovirus in compassion with murine norovirus, poliovirus and coxsackievirus.2018
Author(s)
Ohmine, T., Narai, S., Matsubara, T., Nomura, T., Oda, K., Fukushi, M., Irie, T., Komatsu, T. Tohya, Y., Sakaguchi, T.
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Journal Title
Hiroshima Journal of Medical Sciences
Volume: -
Related Report
Peer Reviewed
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[Journal Article] Inactivation of influenza virus by a supplemental fermented plant product (‘Manda Koso’).2017
Author(s)
Nomura, T., Yoshimoto, R., Kawabata, R., Matsubara, T., Narai, S., Oda, K., Fukushi, M., Irie, T., Sakaguchi, T.
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Journal Title
Hiroshima Journal of Medical Sciences
Volume: 66
Pages: 97-101
NAID
Related Report
Peer Reviewed
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