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The role of inhibitory-type C-type lectin receptors in fungal immunity

Research Project

Project/Area Number 16K19147
Research Category

Grant-in-Aid for Young Scientists (B)

Allocation TypeMulti-year Fund
Research Field Immunology
Research InstitutionChiba University

Principal Investigator

Yabe Rikio  千葉大学, 真菌医学研究センター, 助教 (00598229)

Research Collaborator SAIJO Shinobu  
IWAKURA Yoichiro  
CHUNG Soo-Hyun  
Project Period (FY) 2016-04-01 – 2018-03-31
Project Status Completed (Fiscal Year 2017)
Budget Amount *help
¥4,030,000 (Direct Cost: ¥3,100,000、Indirect Cost: ¥930,000)
Fiscal Year 2017: ¥2,340,000 (Direct Cost: ¥1,800,000、Indirect Cost: ¥540,000)
Fiscal Year 2016: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Keywords真菌 / 自然免疫受容体 / サイトカイン / C型レクチン受容体 / 自然免疫 / 真菌感染 / マクロファージ / 好中球
Outline of Final Research Achievements

C-type lectin receptors are a large family of transmembrane proteins containing extracellular C-type lectin-like carbohydrate-recognition domain(s) and signal transduction region(s), i.e., immunoreceptor tyrosine-based activation motif (ITAM) and immunoreceptor tyrosine-based inhibitory motif (ITIM). Although ITAM-coupling CLRs are best-characterized as direct receptors for fungi, the role of ITIM-bearing CLRs has been poorly understood. In this study, we found that a soluble form of inhibitory-type CLRs bound to Candida species. Furthermore, inhibitory-type CLRs mediated inflammatory cytokine production in macrophages and neutrophils following stimulation with those fungi. These data suggest that inhibitory-type CLRs play an important role in immune responses to fungal infection.

Report

(3 results)
  • 2017 Annual Research Report   Final Research Report ( PDF )
  • 2016 Research-status Report
  • Research Products

    (4 results)

All 2017 2016

All Journal Article (1 results) (of which Int'l Joint Research: 1 results,  Peer Reviewed: 1 results,  Open Access: 1 results,  Acknowledgement Compliant: 1 results) Presentation (2 results) (of which Int'l Joint Research: 1 results) Book (1 results)

  • [Journal Article] Dectin-1 and Dectin-2 promote control of the fungal pathogen Trichophyton rubrum independently of IL-17 and adaptive immunity in experimental deep dermatophytosis2016

    • Author(s)
      Fabio Yoshikawa, Rikio Yabe, Yoichiro Iwakura, Sandro Rogerio de Almeida, Shinobu Saijo
    • Journal Title

      Innate Immunity

      Volume: in press Issue: 5 Pages: 316-24

    • DOI

      10.1177/1753425916645392

    • Related Report
      2016 Research-status Report
    • Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
  • [Presentation] Microbial recognition by C-type lectin receptors encoded in the Dectin-1/Dectin-2 cluster2017

    • Author(s)
      Rikio Yabe, Mutsuki Kobayahi, Maki Wakatsuki, Yukiko Akahori and Shinobu Saijo
    • Organizer
      The 5th Annual Meeting of the International Cytokine and Interferon Society
    • Related Report
      2017 Annual Research Report
    • Int'l Joint Research
  • [Presentation] DCIR-糖鎖間相互作用による骨代謝制御2016

    • Author(s)
      矢部力朗、海部知則、丸橋拓海、西城忍 舘野浩章、平林淳、岩倉洋一郎
    • Organizer
      第35回日本糖質学会年会
    • Place of Presentation
      高知市文化プラザかるぽーと(高知県高知市)
    • Year and Date
      2016-09-03
    • Related Report
      2016 Research-status Report
  • [Book] Dectin-2 in Antimicrobial Immunity and Homeostasis2016

    • Author(s)
      Rikio Yabe, Shinobu Saijo
    • Total Pages
      11
    • Publisher
      Springer
    • Related Report
      2016 Research-status Report

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Published: 2016-04-21   Modified: 2023-12-25  

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