| Project/Area Number |
16K19147
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Immunology
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| Research Institution | Chiba University |
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Principal Investigator |
Yabe Rikio 千葉大学, 真菌医学研究センター, 助教 (00598229)
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| Research Collaborator |
SAIJO Shinobu
IWAKURA Yoichiro
CHUNG Soo-Hyun
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| Project Period (FY) |
2016-04-01 – 2018-03-31
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| Project Status |
Completed (Fiscal Year 2017)
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| Budget Amount *help |
¥4,030,000 (Direct Cost: ¥3,100,000、Indirect Cost: ¥930,000)
Fiscal Year 2017: ¥2,340,000 (Direct Cost: ¥1,800,000、Indirect Cost: ¥540,000)
Fiscal Year 2016: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
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| Keywords | 真菌 / 自然免疫受容体 / サイトカイン / C型レクチン受容体 / 自然免疫 / 真菌感染 / マクロファージ / 好中球 |
|---|
| Outline of Final Research Achievements |
C-type lectin receptors are a large family of transmembrane proteins containing extracellular C-type lectin-like carbohydrate-recognition domain(s) and signal transduction region(s), i.e., immunoreceptor tyrosine-based activation motif (ITAM) and immunoreceptor tyrosine-based inhibitory motif (ITIM). Although ITAM-coupling CLRs are best-characterized as direct receptors for fungi, the role of ITIM-bearing CLRs has been poorly understood. In this study, we found that a soluble form of inhibitory-type CLRs bound to Candida species. Furthermore, inhibitory-type CLRs mediated inflammatory cytokine production in macrophages and neutrophils following stimulation with those fungi. These data suggest that inhibitory-type CLRs play an important role in immune responses to fungal infection.
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