Differential regulation of the antiviral responses
| Project/Area Number |
16K19149
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Immunology
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| Research Institution | The University of Tokyo |
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Principal Investigator |
Okazaki Tomohiko 東京大学, 大学院薬学系研究科(薬学部), 助教 (50724598)
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| Project Period (FY) |
2016-04-01 – 2019-03-31
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| Project Status |
Completed (Fiscal Year 2018)
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| Budget Amount *help |
¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000)
Fiscal Year 2017: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Fiscal Year 2016: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
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| Keywords | インターフェロン / アポトーシス / 細胞死 / カルボキシル化 / 免疫学 |
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| Outline of Final Research Achievements |
I previously reported that type 1 interferon (IFN) production and apoptosis were differentially regulated in response to viral infection. However, the underlying molecular mechanism was remained largely unclear. In this study, we found that post-translational modification of IPS-1 switched its response from caspase activation to IFN production after viral infection.
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| Academic Significance and Societal Importance of the Research Achievements |
抗ウイルス応答の使い分け機構を解明できたことで、抗ウイルス応答の使い分けを人為的に操作できる可能性が生まれた。感染細胞の抗ウイルス応答の使い分けを人為的に制御することは、抗ウイルス応答が個体に与える悪影響を回避しながら、ウイルスを排除する治療方法の開発の基盤となり得る。
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Report
(4 results)
Research Products
(10 results)
