Epigenetic regulatory mechanisms of immunoglobulin gene rearrangements in autoimmune diseases

Research Project

Project/Area Number	16K19152
Research Category	Grant-in-Aid for Young Scientists (B)
Allocation Type	Multi-year Fund
Research Field	Immunology
Research Institution	Kyoto University
Principal Investigator	YAMADA Norishige 京都大学, 医学研究科, 特定研究員 (60625242)
Project Period (FY)	2016-04-01 – 2018-03-31
Project Status	Completed (Fiscal Year 2017)
Budget Amount *help	¥3,640,000 (Direct Cost: ¥2,800,000、Indirect Cost: ¥840,000) Fiscal Year 2017: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000) Fiscal Year 2016: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
Keywords	自己免疫疾患 / 免疫グロブリン遺伝子再構成 / SLE / 免疫グロブリン再構成 / エピジェネティクス
Outline of Final Research Achievements	Systemic lupus erythematosus (SLE) is a chronic autoimmune inflammatory disease that can affect almost any part of the body, and B cell play critical roles in pathogenesis of SLE through autoantibody production. In a mouse model of SLE, aberrant gene rearrangement and transcription were found at immunoglobulin heavy chain locus in immature B cells. In addition, we observed abnormal bone marrow B-cell development in mouse model of SLE. Moreover, we successfully generated a mouse model for B cell conditional deletion of differentiation regulatory factor. These findings open the possibility of using immunoglobulin rearrangement status as diagnostic tool for SLE.

Report

(3 results)