| Project/Area Number |
16K19160
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Immunology
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| Research Institution | Kumamoto University |
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Principal Investigator |
Akahoshi Tomohiro 熊本大学, エイズ学研究センター, 特定事業研究員 (10635783)
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| Research Collaborator |
GATANAGA Hiroyuki 国立国際医療研究センター, エイズ治療・研究開発センター
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| Project Period (FY) |
2016-04-01 – 2018-03-31
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| Project Status |
Completed (Fiscal Year 2017)
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| Budget Amount *help |
¥4,030,000 (Direct Cost: ¥3,100,000、Indirect Cost: ¥930,000)
Fiscal Year 2017: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2016: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
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| Keywords | HIV-1 / CTL / HLAクラスⅠ関連変異 / エピトープ推定 / 変異エピトープ / ネオエピトープ / 変異特異的CTL / HLA関連多型 / 感染症 / ウイルス / 細胞・組織 / 免疫学 |
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| Outline of Final Research Achievements |
In present study, we aimed to clarify to what extent HIV-1-specific CD8+ cytotoxic T cells (CTL) recognizing HLA-adapted escape mutants are induced in a cohort of chronically HIV-1-infeand Japanese individuals and whether they contribute to control of HIV-1 replication. Among mutant epitopes which were predicted based on cohort’s consensus viral sequence containing HLA-associated mutations, we focused on two epitopes in which mixture of wild type (WT) and mutant viruses and/or frequent selection and reversion of those viruses were longitudinally observed. In those epitopes, cross-reactive CTLs, which recognized both WT and mutant peptides, and mutant-specific CTLs were induced in HIV-1-infected individuals. These results indicated that de novo CTLs recognizing HLA-adapted escape mutants elicited in chronic phase of HIV-1 infection may contribute to control of HIV-1 infection.
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