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Effects of cardiopulmonary resuscitation on neurological outcome in elderly patients with out-of-hospital cardiac arrest

Research Project

Project/Area Number 16K19171
Research Category

Grant-in-Aid for Young Scientists (B)

Allocation TypeMulti-year Fund
Research Field Medical sociology
Research InstitutionKanazawa University

Principal Investigator

Funada Akira  金沢大学, 附属病院, 講師 (20602626)

Project Period (FY) 2016-04-01 – 2019-03-31
Project Status Completed (Fiscal Year 2018)
Budget Amount *help
¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000)
Fiscal Year 2018: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2017: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2016: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Keywords院外心停止 / 心肺蘇生 / 高齢者 / 救急医療 / 医療倫理 / 院外心肺停止
Outline of Final Research Achievements

Using Japanese nationwide out-of-hospital cardiac arrest (OHCA) registry, we analyzed the rate and trend of neurologically intact survival in elderly patients with OHCA. The rate of neurologically intact survival significantly improved in patients aged 65-74 and 75-89 years. However, in patients aged 90 years or over, no improvement was observed. We developed a prediction chart using variables significantly associated with increased chances of neurologically intact survival, such as initial documented rhythm, witnessed status, and age, to estimate the neurologically intact survival rate after OHCA. The estimated neurologically intact survival rate in patients with unwitnessed OHCA with a non-shockable rhythm was <1% in all age groups. Particularly, in elderly patients with OHCA, this information can help in deciding whether to withhold or terminate resuscitation efforts. However, as the neurologically intact survival rate has improved annually, the prediction chart needs to be updated.

Academic Significance and Societal Importance of the Research Achievements

本研究の特色は、十分に解明されていないわが国における高齢院外心停止傷病者の特徴を明らかにし、高齢者に対する蘇生処置の意義を検討することである。本研究の成果は、今後のさらなる超高齢化社会の進行に伴い自然増加が予想される高齢院外心停止傷病者に対する国民の意識改革、病院前救護体制の改革、高齢者の望まない救急搬送や無益な救急搬送の減少、救急搬送受け入れ病院の負担軽減、限られた医療資源の効率的な活用等に一役を担うものと考えられ、社会的、経済的、倫理的に非常に意義があると考える。

Report

(4 results)
  • 2018 Annual Research Report   Final Research Report ( PDF )
  • 2017 Research-status Report
  • 2016 Research-status Report
  • Research Products

    (29 results)

All 2019 2018 2017 2016 Other

All Journal Article (13 results) (of which Peer Reviewed: 12 results,  Open Access: 6 results,  Acknowledgement Compliant: 2 results) Presentation (13 results) (of which Int'l Joint Research: 11 results) Remarks (3 results)

  • [Journal Article] Impact of prehospital physician-led cardiopulmonary resuscitation on neurologically intact survival after out-of-hospital cardiac arrest: A nationwide population-based observational study2019

    • Author(s)
      Yoshikazu Goto、Akira Funada、Yumiko Goto
    • Journal Title

      Resuscitation

      Volume: 136 Pages: 38-46

    • DOI

      10.1016/j.resuscitation.2018.11.014

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Field termination-of-resuscitation rule for refractory out-of-hospital cardiac arrests in Japan2019

    • Author(s)
      Yoshikazu Goto、Akira Funada、Tetsuo Maeda, Hirofumi Okada, Yumiko Goto
    • Journal Title

      Journal of Cardiology

      Volume: 73 Issue: 3 Pages: 240-246

    • DOI

      10.1016/j.jjcc.2018.12.002

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Relationship between emergency medical services response time and bystander intervention in patients with out-of-hospital cardiac arrest.2018

    • Author(s)
      Goto Y, Funada A, Goto Y
    • Journal Title

      J Am Heart Assoc

      Volume: 7 Issue: 9

    • DOI

      10.1161/jaha.117.007568

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Effects of prehospital epinephrine administration on neurologically intact survival in bystander-witnessed out-of-hospital cardiac arrest patients with non-shockable rhythm depend on prehospital cardiopulmonary resuscitation duration required to hospital arrival.2018

    • Author(s)
      Funada A, Goto Y, Tada H, Shimojima M, Hayashi K, Kawashiri MA, Yamagishi M.
    • Journal Title

      Heart Vessels.

      Volume: 33 Issue: 12 Pages: 1525-1533

    • DOI

      10.1007/s00380-018-1205-6

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Duration of cardiopulmonary resuscitation in patients without prehospital return of spontaneous circulation after out-of-hospital cardiac arrest: Results from a severity stratification analysis.2018

    • Author(s)
      Funada A, Goto Y, Tada H, Teramoto R, Shimojima M, Hayashi K, Kawashiri MA, Yamagishi M.
    • Journal Title

      Resuscitation.

      Volume: 124 Pages: 69-75

    • DOI

      10.1016/j.resuscitation.2018.01.008

    • Related Report
      2017 Research-status Report
    • Peer Reviewed
  • [Journal Article] Reply to: Over time, differences in survival and favorable neurologic outcomes between conventional and compression-only cardiopulmonary resuscitation have been gradually reduced in pediatric out-of-hospital cardiac arrest2018

    • Author(s)
      Goto Yoshikazu、Funada Akira、Goto Yumiko
    • Journal Title

      Resuscitation

      Volume: 124 Pages: e9-e10

    • DOI

      10.1016/j.resuscitation.2017.12.023

    • NAID

      120006452367

    • Related Report
      2017 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Conventional versus chest-compression-only cardiopulmonary resuscitation by bystanders for children with out-of-hospital cardiac arrest2018

    • Author(s)
      Goto Yoshikazu、Funada Akira、Goto Yumiko
    • Journal Title

      Resuscitation

      Volume: 122 Pages: 126-134

    • DOI

      10.1016/j.resuscitation.2017.10.015

    • Related Report
      2017 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Age-Specific Differences in the Duration of Prehospital Cardiopulmonary Resuscitation Administered by Emergency Medical Service Providers Necessary to Achieve Favorable Neurological Outcome After Out-of-Hospital Cardiac Arrest2017

    • Author(s)
      Funada Akira , Goto Yoshikazu, Tada Hayato, Teramoto Ryota, Shimojima Masaya, Hayashi Kenshi, Yamagishi Masakazu
    • Journal Title

      Circulation Journal

      Volume: 81 Issue: 5 Pages: 652-659

    • DOI

      10.1253/circj.CJ-16-1251

    • NAID

      130005612045

    • ISSN
      1346-9843, 1347-4820
    • Related Report
      2017 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Prehospital predictors of neurological outcomes in out-of-hospital cardiac arrest patients aged 95 years and older: A nationwide population-based observational study2017

    • Author(s)
      Akira Funada, Yoshikazu Goto, Tetsuo Maeda, Hayato Tada, Ryota Teramoto, Yoshihiro Tanaka, Kenshi Hayashi, Masakazu Yamagishi
    • Journal Title

      Journal of Cardiology

      Volume: 69 Issue: 1 Pages: 340-4

    • DOI

      10.1016/j.jjcc.2016.07.011

    • Related Report
      2016 Research-status Report
    • Peer Reviewed / Acknowledgement Compliant
  • [Journal Article] 高齢院外心停止例における神経学的転帰良好を伴った生存率の経時的変化-全国前向きウツタイン登録からの報告2017

    • Author(s)
      舟田晃、後藤由和、林研至、山岸正和
    • Journal Title

      循環器専門医

      Volume: 25 Pages: 22-26

    • NAID

      130007665754

    • Related Report
      2016 Research-status Report
  • [Journal Article] Age-specific differences in prognostic significance of rhythm conversion from initial non-shockable to shockable rhythm and subsequent shock delivery in out-of-hospital cardiac arrest2016

    • Author(s)
      Akira Funada, Yoshikazu Goto, Hayato Tada, Ryota Teramoto, Masaya Shimojima, Kenshi Hayashi, Masakazu Yamagishi
    • Journal Title

      Resuscitation

      Volume: 108 Pages: 61-7

    • DOI

      10.1016/j.resuscitation.2016.09.013

    • Related Report
      2016 Research-status Report
    • Peer Reviewed / Acknowledgement Compliant
  • [Journal Article] Duration of prehospital cardiopulmonary resuscitation and favorable neurological outcomes for pediatric out-of-hospital cardiac arrests: A nationwide, population-based cohort study.2016

    • Author(s)
      Goto Y, Funada A, Goto Y.
    • Journal Title

      Circulation

      Volume: 134 Issue: 25 Pages: 2046-2059

    • DOI

      10.1161/circulationaha.116.023821

    • Related Report
      2016 Research-status Report
    • Peer Reviewed
  • [Journal Article] Subsequent shockable rhythm during out-of-hospital cardiac arrest in children with initial non-shockable rhythms: a nationwide population-based observational study.2016

    • Author(s)
      Goto Y, Funada A, Goto Y.
    • Journal Title

      Am Heart Assoc

      Volume: 5 Issue: 10

    • DOI

      10.1161/jaha.116.003589

    • Related Report
      2016 Research-status Report
    • Peer Reviewed / Open Access
  • [Presentation] Prehospital epinephrine in combination with high quality cardiopulmonary resuscitation may improve neurologically intact survival in out-of-hospital cardiac arrest with non-shockable rhythm2018

    • Author(s)
      Funada A, Goto Y, Yamagishi M
    • Organizer
      ESC congress 2018
    • Related Report
      2018 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Prehospital epinephrine effect on neurologically intact survival in out-of-hospital cardiac arrest with non-shockable rhythm depends on cardiopulmonary resuscitation duration until hospital arrival2018

    • Author(s)
      Funada A, Goto Y, Yamagishi M
    • Organizer
      ESC congress 2018
    • Related Report
      2018 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Effects of the Presence of Emergency Medical Service Physician on Neurologically Intact Survival After an Out-of-hospital Cardiac Arrest: a Nationwide Population-based Observational Study2018

    • Author(s)
      Funada A, Goto Y, Tada H, Shimojima M, Okada H, Kawashiri M
    • Organizer
      AHA Resuscitation Science Symposium 2018
    • Related Report
      2018 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Impact of Time to Return of Spontaneous Circulation on Neurologically Intact Survival in Patients with Out-of-hospital Cardiac Arrest According to Age: Evidence from a Large-Scale Registry in Japan2018

    • Author(s)
      Funada A, Goto Y, Tada H, Shimojima M, Okada H, Kawashiri M
    • Organizer
      AHA Resuscitation Science Symposium 2018
    • Related Report
      2018 Annual Research Report
    • Int'l Joint Research
  • [Presentation] 院外心停止症例における神経学的転帰良好予測表2018

    • Author(s)
      舟田晃、後藤由和
    • Organizer
      第46回日本救急医学会総会・学術集会
    • Related Report
      2018 Annual Research Report
  • [Presentation] Prediction Chart for Neurologically Intact Survival After Out-of-Hospital Cardiac Arrest: Evidence from A Japanese Nationwide Population-based Cohort Study2018

    • Author(s)
      Funada Akira, Goto Yoshikazu, Yamagishi Masakazu
    • Organizer
      ACC Scientific Session 2018
    • Related Report
      2017 Research-status Report
    • Int'l Joint Research
  • [Presentation] コントロバーシー 1 超高齢社会における心肺蘇生判断を問う~日本人の死生観とエビデンスの見地から~, Trends in survival with favorable neurological outcome among elderly patients with out-of-hospital cardiac arrest: insight from a Japanese nationwide registry2017

    • Author(s)
      舟田晃、後藤由和、山岸正和
    • Organizer
      第81回日本循環器学会学術集会
    • Place of Presentation
      金沢
    • Year and Date
      2017-03-17
    • Related Report
      2016 Research-status Report
  • [Presentation] Effects of Prehospital Epinephrine Administration on Neurologically Intact Survival in Bystander-witnessed Out-of-hospital Cardiac Arrest Patients with Initial Non-shockable Rhythm: Based on Emergency Medical Service Response Time2017

    • Author(s)
      Funada Akira, Goto Yoshikazu, Tada Hayato, Yamagishi Masakazu
    • Organizer
      AHA Scientific Session 2017
    • Related Report
      2017 Research-status Report
    • Int'l Joint Research
  • [Presentation] Prehospital cardiopulmonary resuscitation duration and favourable neurological outcome after out-of-hospital cardiac arrest in patients without prehospital return of spontaneous circulation2017

    • Author(s)
      Funada Akira, Goto Yoshikazu, Tada Hayato, Teramoto Ryota, Shimojima Masaya, Hayashi Kenshi, Yamagishi Masakazu
    • Organizer
      ESC Congress 2017
    • Related Report
      2017 Research-status Report
    • Int'l Joint Research
  • [Presentation] Age-specific Difference in the Prognostic Significance of Conversion from Nonshockable to Shockable Rhythm in Out-of-hospital Cardiac Arrest: a Prospective Nationwide Population-based Cohort Study in Japan2016

    • Author(s)
      Akira Funada, Yoshikazu Goto, Hayato Tada, Ryota Teramoto, Masaya Shimojima, Kenshi Hayashi, Masakazu Yamagishi
    • Organizer
      AHA Scientific Session 2016
    • Place of Presentation
      New Orleans, US
    • Year and Date
      2016-11-14
    • Related Report
      2016 Research-status Report
    • Int'l Joint Research
  • [Presentation] Impact of Age on Optimal Cardiopulmonary Resuscitation Duration to Achieve Favorable Neurological Outcomes after Out-of-hospital Cardiac Arrest: Evidence from Large Scale Registry in Japan2016

    • Author(s)
      Akira Funada, Yoshikazu Goto, Hayato Tada, Ryota Teramoto, Masaya Shimojima, Kenshi Hayashi, Masakazu Yamagishi
    • Organizer
      AHA Scientific Session 2016
    • Place of Presentation
      New Orleans, US
    • Year and Date
      2016-11-14
    • Related Report
      2016 Research-status Report
    • Int'l Joint Research
  • [Presentation] An improved prediction scoring system to estimate survival with favorable neurological outcomes after out-of-hospital cardiac arrest: evidence from a nationwide population-based cohort study in Japan2016

    • Author(s)
      Akira Funada, Yoshikazu Goto, Hayato Tada, Ryota Teramoto, Masaya Shimojima, Kenshi Hayashi, Masakazu Yamagishi
    • Organizer
      AHA Scientific Session 2016
    • Place of Presentation
      New Orleans, US
    • Year and Date
      2016-11-13
    • Related Report
      2016 Research-status Report
    • Int'l Joint Research
  • [Presentation] Prognostic impact of prehospital return of spontaneous circulation on favourable neurological outcomes after out-of-hospital cardiac arrest in elderly patients aged 95 years and older2016

    • Author(s)
      Akira Funada, Yoshikazu Goto, Tetsuo Maeda, Ryota Teramoto, Kenshi Hayashi, Masakazu Yamagishi
    • Organizer
      ESC Congress 2016
    • Place of Presentation
      Roma, Italy
    • Year and Date
      2016-08-30
    • Related Report
      2016 Research-status Report
    • Int'l Joint Research
  • [Remarks] 金沢大学 大学院医学系研究科 循環器病態内科学(旧第二内科)

    • URL

      http://intmed2.w3.kanazawa-u.ac.jp/

    • Related Report
      2018 Annual Research Report
  • [Remarks] 金沢大学大学院医歯薬保険学総合研究科 循環器病態内科学

    • URL

      http://intmed2.w3.kanazawa-u.ac.jp/

    • Related Report
      2017 Research-status Report
  • [Remarks] 金沢大学大学院医薬保健学総合研究科 循環器病態内科学

    • URL

      http://intmed2.w3.kanazawa-u.ac.jp/

    • Related Report
      2016 Research-status Report

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Published: 2016-04-21   Modified: 2020-03-30  

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