| Budget Amount *help |
¥4,030,000 (Direct Cost: ¥3,100,000、Indirect Cost: ¥930,000)
Fiscal Year 2018: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2017: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2016: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
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| Outline of Final Research Achievements |
Adult T-cell leukemia (ATL) is caused by infection with HTLV-1, and there is no effective treatment for ATL. We have found that TMNAA is potent and selective inhibitor of the ATL. In this study, we evaluated the mechanism of action of TMNAA for ATL using DNA microarray. However, we did not obtained the common gene expression to TMNAA treated ATL cell lines. On the other hand, we found that the inhibitory effect of TMNAA for ATL cell lines exert anti-ATL effect by inducing apoptosis.
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