Examination of multiple myeloma prognosis predictive biomarkers based on analysis of PD-1 polymorphisms
| Project/Area Number |
16K19190
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Laboratory medicine
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| Research Institution | Gunma University |
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Principal Investigator |
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| Research Collaborator |
MURAKAMI hirokazu
SAITOH takayuki
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| Project Period (FY) |
2016-04-01 – 2019-03-31
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| Project Status |
Completed (Fiscal Year 2018)
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| Budget Amount *help |
¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000)
Fiscal Year 2018: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2017: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2016: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
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| Keywords | 多発性骨髄腫 / PD-1 / 遺伝子多型 / 免疫チェックポイント / PD-L1 / 一塩基多型 / 臨床血液学 / PD-1 ligand / 骨髄腫 |
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| Outline of Final Research Achievements |
We investigated the impact of PDCD1 (3 single nucleotide polymorphisms; SNPs), PDCD1LG1 (2 SNPs), CTLA4 (4 SNPs), IDO1 (1 SNPs) and IDO2 (1 SNPs) polymorphisms on susceptibility and clinical features of multiple myeloma (MM) patients.
The PDCD1 high-expression type and IDO2 high-activity type were associated with the susceptibility of MM. In addition, the higher frequencies of patients with CTLA4 and PDCDLG1 high-expression types were observed in more malignant clinical variables. However, there were no significant differences between all polymorphisms and overall survival.
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| Academic Significance and Societal Importance of the Research Achievements |
本研究成果は、当初期待したPD-1遺伝子多型の多発性骨髄腫患者の予後予測バイオマーカ―としての有効性を認められなかった。しかしながら、PD-1をはじめとした免疫チェックポイント分子の遺伝子多型が多発性骨髄腫の発症やより重症な症状への関係性することが認められ、腫瘍に対する免疫を抑制的に調節する分子の遺伝的な背景が、まだ明らかとされていない多発性骨髄腫の発症および進行のメカニズムに何らかの影響を与えることが解明された。
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Report
(4 results)
Research Products
(6 results)
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[Presentation] Programmed cell death 1 gene polymorphisms associated with the clinical features of multiple myeloma.2017
Author(s)
Tetsuhiro Kasamatsu, Maaya Awata, Yukihiro Kanai, Keisuke Murata, Morio Matsumoto, Morio Sawamura, Makiko Takizawa, Akihiko Yokohama, Nanami Gotoh, Hiroshi Handa, Takayuki Saitoh, Hirokazu Murakami
Organizer
XXXth International Symposium on Technical Innovations in Laboratory Hematology
Place of Presentation
Hawaii Convention Center
Year and Date
2017-05-04
Related Report
Int'l Joint Research
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[Presentation] PD-1 and PD-L1 gene polymorphisms associated with the clinical features of multiple myeloma2017
Author(s)
Kasamatsu T, Awata M, Kanai Y, Murata K, Ohata M, Ishihara R, Murakami M, Watanabe S, Ino R, Kitamura Y, Honma K, Masuda Y, Takahashi N, Gotoh N, Matsumoto M, Sawamura M, Shimizu H, Ishizaki T, Takizawa M, Koiso H, Yokohama A, Tsukamoto N, Handa H, Saitoh T, Murakami H.
Organizer
第79回 日本血液学会学術集会
Related Report
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