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Elucidation of the anti-atherogenic mechanism of adiponectin

Research Project

Project/Area Number 16K19192
Research Category

Grant-in-Aid for Young Scientists (B)

Allocation TypeMulti-year Fund
Research Field Laboratory medicine
Research InstitutionShinshu University

Principal Investigator

Kakino Akemi  信州大学, 先鋭領域融合研究群バイオメディカル研究所, 助教(特定雇用) (00534637)

Project Period (FY) 2016-04-01 – 2018-03-31
Project Status Completed (Fiscal Year 2017)
Budget Amount *help
¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000)
Fiscal Year 2017: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Fiscal Year 2016: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Keywords変性LDL / アディポネクチン / 酸化LDL
Outline of Final Research Achievements

Adiponectin exhibits anti-atherogenic properties, but the underlying mechanisms are not well understood. To determine how adiponectin exerts its anti-atherogenic action and how pro-atherogenic conditions affect adiponectin action, we studied the interactions of adiponectin and oxidized low-density lipoprotein (oxLDL). Adiponectin selectively bound oxLDL and inhibited oxLDL uptake into endothelial cells and macrophages. Adiponectin also suppressed oxLDL-induced cellular responses. Thus, we propose that the direct inhibitory action of adiponectin against atherogenic LDL might be crucial for the anti-atherogenic property of adiponectin.

Academic Significance and Societal Importance of the Research Achievements

本研究では、アディポネクチンが酸化LDLに結合し、酸化LDL依存性の細胞障害に対して抑制的に働くことをin vitroの解析により明らかにした。また、ヒト血漿から向動脈硬化性LDLを抽出し、このLDL亜分画にアディポネクチンが濃縮して存在していることがわかり、生体内でもアディポネクチンが(酸化)変性LDLブロッカーとして機能し得ることを示した。このようなアディポネクチンの新たな抗動脈硬化作用機構が明らかになったことは、動脈硬化性疾患への新しい対処法につながる可能性がある。

Report

(3 results)
  • 2017 Annual Research Report   Final Research Report ( PDF )
  • 2016 Research-status Report
  • Research Products

    (10 results)

All 2017 2016

All Journal Article (5 results) (of which Int'l Joint Research: 1 results,  Peer Reviewed: 3 results,  Open Access: 2 results,  Acknowledgement Compliant: 1 results) Presentation (5 results) (of which Int'l Joint Research: 2 results)

  • [Journal Article] Editorial commentary: L5: An LDL fraction in which pathogenic activity of LDL is concentrated2017

    • Author(s)
      Sawamura, T., Fujita, Y., Horiuchi, S., Kakino, A.
    • Journal Title

      Trends Cardiovasc Med

      Volume: 27 Issue: 4 Pages: 247-248

    • DOI

      10.1016/j.tcm.2016.12.004

    • Related Report
      2017 Annual Research Report
  • [Journal Article] LOX-1 in Ischemic Stroke2017

    • Author(s)
      Sawamura, T., Fujita, Y., Horiuchi, S., Kakino, A.
    • Journal Title

      Journal of Atherosclerosis and Thrombosis

      Volume: 24 Issue: 6 Pages: 566-568

    • DOI

      10.5551/jat.ED071

    • NAID

      130005687830

    • ISSN
      1340-3478, 1880-3873
    • Related Report
      2017 Annual Research Report
  • [Journal Article] Developmental Endothelial Locus-1 (Del-1) Inhibits Oxidized Low-Density Lipoprotein Activity by Direct Binding, and Its Overexpression Attenuates Atherogenesis in Mice2016

    • Author(s)
      Akemi Kakino, Yoshiko Fujita, Atsushi Nakano, Sayaka Horiuchi, Tatsuya Sawamura
    • Journal Title

      Circulation Journal

      Volume: 80 Issue: 12 Pages: 2541-2549

    • DOI

      10.1253/circj.CJ-16-0808

    • NAID

      130005284982

    • ISSN
      1346-9843, 1347-4820
    • Related Report
      2016 Research-status Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] Deletion of LOX-1 Protects against Heart Failure Induced by Doxorubicin.2016

    • Author(s)
      Yokoyama C, Aoyama T, Ido T, Kakino A, Shiraki T, Tanaka T, Nishigaki K, Hasegawa A, Fujita Y, Sawamura T, Minatoguchi S.
    • Journal Title

      PLoS One

      Volume: 11(5) Issue: 5 Pages: e0154994-e0154994

    • DOI

      10.1371/journal.pone.0154994

    • Related Report
      2016 Research-status Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] High Levels of Soluble Lectin-Like Oxidized Low-Density Lipoprotein Receptor-1 in Acute Stroke: An Age- and Sex-Matched Cross-Sectional Study2016

    • Author(s)
      Yokota, C., Sawamura, T., Watanabe, M., Kokubo, Y., Fujita, Y., Kakino, A., Nakai, M., Toyoda, K., Miyamoto, Y. and Minematsu, K.
    • Journal Title

      Journal of Atherosclerosis and Thrombosis

      Volume: 23 Issue: 10 Pages: 1222-1226

    • DOI

      10.5551/jat.32466

    • NAID

      130005598268

    • ISSN
      1340-3478, 1880-3873
    • Related Report
      2016 Research-status Report
    • Peer Reviewed
  • [Presentation] アディポネクチン系と酸化LDL系の相互拮抗作用2017

    • Author(s)
      垣野明美, 藤田佳子, 堀内清香, 沢村達也
    • Organizer
      第27回日本循環薬理学会
    • Related Report
      2017 Annual Research Report
  • [Presentation] アディポネクチンの抗動脈硬化作用の検討2017

    • Author(s)
      垣野明美, 藤田佳子, 堀内清香, 沢村達也
    • Organizer
      第64回中部日本生理学会
    • Related Report
      2017 Annual Research Report
  • [Presentation] 受容体結合活性で測定する変性LDL2017

    • Author(s)
      沢村達也, 岡村智教, 藤田佳子, 堀内清香, 垣野明美
    • Organizer
      第49回日本動脈硬化学会
    • Related Report
      2017 Annual Research Report
  • [Presentation] Oxidized LDL and adiponectin interact and regulate the other’s respective functions.2016

    • Author(s)
      Kakino, A., Fujita, Y., Sawamura, T.
    • Organizer
      American Heart Association’s Scientific Sessions 2016
    • Place of Presentation
      New Orleans, USA
    • Year and Date
      2016-11-12
    • Related Report
      2016 Research-status Report
    • Int'l Joint Research
  • [Presentation] Adiponectin as a blocker of oxidized LDL.2016

    • Author(s)
      Kakino, A., Fujita, Y., Sawamura, T.
    • Organizer
      The 84th European Atherosclerosis Society Congress (EAS 2016)
    • Place of Presentation
      Innsbruck, Austria
    • Year and Date
      2016-05-29
    • Related Report
      2016 Research-status Report
    • Int'l Joint Research

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Published: 2016-04-21   Modified: 2024-01-30  

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