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Effect of antimicrobial peptide cathelicidin on atopic dermatitis

Research Project

Project/Area Number 16K19217
Research Category

Grant-in-Aid for Young Scientists (B)

Allocation TypeMulti-year Fund
Research Field Pain science
Research InstitutionJuntendo University

Principal Investigator

Umehara Yoshie  順天堂大学, 医学研究科, 博士研究員 (40707072)

Research Collaborator KAMATA Yayoi  順天堂大学, 大学院・医学研究科, 助教 (00410035)
MATSUDA Hironori  順天堂大学, 大学院・医学研究科, 技術員
NIYONSABA Francois  順天堂大学, 国際教養学部, 教授 (60365640)
TOMINAGA Mitsutoshi  順天堂大学, 大学院・医学研究科, 准教授 (50468592)
Project Period (FY) 2016-04-01 – 2018-03-31
Project Status Completed (Fiscal Year 2017)
Budget Amount *help
¥4,030,000 (Direct Cost: ¥3,100,000、Indirect Cost: ¥930,000)
Fiscal Year 2017: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2016: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
Keywords難治性かゆみ / アトピー性皮膚炎 / 抗菌ペプチド / カテリシジン / アトピー性皮膚炎モデルNC/Ngaマウス / ドライスキン / かゆみ / Sema3A
Outline of Final Research Achievements

We investigated the effect of antimicrobial peptide cathelicidin on atopic dermatitis (AD). Following induction of AD-like symptoms on NC/Nga mice, cathelicidin mCRAMP ointment was applied to the lesional skin. Although dermatitis scores and scratching behavior were not suppressed, stratum corneum hydration was improved by the ointment. We also found that expressions of calpain I and BH mRNA in epidermis were increased. These data suggest that increased NMFs by upregulation of NMF-generating proteases improve stratum corneum hydration.

Report

(3 results)
  • 2017 Annual Research Report   Final Research Report ( PDF )
  • 2016 Research-status Report
  • Research Products

    (17 results)

All 2017 2016 Other

All Journal Article (7 results) (of which Peer Reviewed: 7 results,  Open Access: 1 results) Presentation (8 results) (of which Int'l Joint Research: 1 results) Remarks (2 results)

  • [Journal Article] Antimicrobial peptides human LL-37 and β-defensin-3 modulate the expression of nerve elongation factors in human epidermal keratinocytes2017

    • Author(s)
      Umehara Yoshie、Kamata Yayoi、Tominaga Mitsutoshi、Niyonsaba Fran?ois、Ogawa Hideoki、Takamori Kenji
    • Journal Title

      Journal of Dermatological Science

      Volume: 88 Issue: 3 Pages: 365-367

    • DOI

      10.1016/j.jdermsci.2017.07.010

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Involvement of μ-opioid Receptors and κ-opioid Receptors in Itch-related Scratching Behaviour of Imiquimod-induced Psoriasis-like Dermatitis in Mice2017

    • Author(s)
      Takahashi N, Tominaga M, Kosaka R, Kamata Y, Umehara Y, Matsuda H, Sakaguchi A, Ogawa H, Takamori K
    • Journal Title

      Acta Dermato Venereologica

      Volume: 97 Issue: 8 Pages: 928-933

    • DOI

      10.2340/00015555-2704

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Oral administration of milk-derived phospholipids inhibits penetration of cutaneous nerve fibres into epidermis in a mouse model of acute dry skin2017

    • Author(s)
      Sakaguchi A, Kamata Y, Takahashi N, Matsuda H, Kosaka R, Umehara Y, Ogawa H, Tominaga M, Takamori K
    • Journal Title

      Clinical and Experimental Dermatology

      Volume: 42 Issue: 8 Pages: 890-894

    • DOI

      10.1111/ced.13207

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Differences in therapeutic effects of topically applied corticosteroid and tacrolimus on atopic dermatitis-like symptoms in NC/Nga mice.2016

    • Author(s)
      Atsushi Noguchi, Mitsutoshi Tominaga, Nobuaki Takahashi, Hironori Matsuda, Yayoi Kamata, Yoshie Umehara, Ko Kyi Chan, Yasushi Suga, Hideoki Ogawa, Kenji Takamori
    • Journal Title

      J Dermatol Sci

      Volume: 86 Issue: 1 Pages: 54-62

    • DOI

      10.1016/j.jdermsci.2016.12.015

    • Related Report
      2017 Annual Research Report 2016 Research-status Report
    • Peer Reviewed
  • [Journal Article] Relationships among plasma granzyme B level, pruritus and dermatitis in patients with atopic dermatitis.2016

    • Author(s)
      Kamata Y, Kimura U, Matsuda H, Tengara S, Kamo A, Umehara Y, Iizumi K, Kawasaki H, Suga Y, Ogawa H, Tominaga M, Takamori K.
    • Journal Title

      J Dermatol Sci

      Volume: 84 Issue: 3 Pages: 266-271

    • DOI

      10.1016/j.jdermsci.2016.09.009

    • Related Report
      2016 Research-status Report
    • Peer Reviewed
  • [Journal Article] Neurotropin suppresses itch-related behavior in NC/Nga mice with atopic dermatitis-like symptoms.2016

    • Author(s)
      Kamo A, Tominaga M, Matsuda H, Kina K, Kamata Y, Umehara Y, Ogawa H, Takamori K.
    • Journal Title

      J Dermatol Sci

      Volume: 81 Issue: 3 Pages: 212-215

    • DOI

      10.1016/j.jdermsci.2015.11.014

    • Related Report
      2016 Research-status Report
    • Peer Reviewed
  • [Journal Article] Possible anti-pruritic mechanisms of cyclosporine A in atopic dermatitis.2016

    • Author(s)
      Ko KC, Tominaga M, Kamata Y, Umehara Y, Matsuda H, Takahashi N, Kina K, Ogawa M, Ogawa H, Takamori K.
    • Journal Title

      Acta Derm Venereol

      Volume: 未定 Issue: 5 Pages: 624-629

    • DOI

      10.2340/00015555-2318

    • Related Report
      2016 Research-status Report
    • Peer Reviewed / Open Access
  • [Presentation] A method to differentiate peripheral neurons from human induced pluripotent stem cells to develop treatments for intractable itch2017

    • Author(s)
      Yoshie Umehara, Mitsutoshi Tominaga, Hironori Matsuda, Nobuaki Takahashi, Yayoi Kamata, Hideoki Ogawa, Kenji Takamori
    • Organizer
      日本研究皮膚科学会 第42回年次学術大会・総会
    • Related Report
      2017 Annual Research Report
  • [Presentation] Calcium increases semaphorin 3A expression by activating PKC/MAPK/AP-1 signaling axis in normal human epidermal keratinocytes2017

    • Author(s)
      Yayoi Kamata, Yoshie Umehara, Azumi Sakaguchi, Yasushi Suga, Hideoki Ogawa, Mitsutoshi Tominaga, Kenji Takamori
    • Organizer
      日本研究皮膚科学会 第42回年次学術大会・総会
    • Related Report
      2017 Annual Research Report
  • [Presentation] 乳由来リン脂質の経口投与は急性ドライスキンモデルマウスにおける表皮内神経線維の増生を抑制する2017

    • Author(s)
      坂口 安澄、鎌田 弥生、高橋 伸明、松田 浩則、幸坂 涼平、梅原 芳恵、須賀 康、冨永 光俊、髙森 建二
    • Organizer
      第47回日本皮膚アレルギー・接触皮膚炎学会総会学術大会
    • Related Report
      2017 Annual Research Report
  • [Presentation] Sema3A expression is regulated by calcium/PKC/MAPK/AP-1 signaling axis in normal human epidermal keratinocytes2017

    • Author(s)
      Yayoi Kamata, Yoshie Umehara, Azumi Sakaguchi, Yasushi Suga, Mitsutoshi Tominaga, Kenji Takamori
    • Organizer
      9th World Congress of Itch
    • Related Report
      2017 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Effects of antimicrobial peptide LL-37 on expression of natural moisturizing factor-generating proteases in epidermal keratinocytes2016

    • Author(s)
      Yoshie Umehara, Yayoi Kamata, Mitsutoshi Tominaga, Francois Niyonsaba, Hideoki Ogawa, Kenji Takamori
    • Organizer
      日本研究皮膚科学会 第 41 回年次学術大会・総会
    • Place of Presentation
      仙台
    • Year and Date
      2016-12-09
    • Related Report
      2016 Research-status Report
  • [Presentation] Serum lipocalin-2 is a potential biomarker for pruritus in patients with psoriasis2016

    • Author(s)
      Mitsutoshi Tominaga, Nobuaki Takahashi, Utako Kimura, Yayoi Kamata, Yoshie Umehara, Yasushi Suga, Hideoki Ogawa, Kenji Takamori
    • Organizer
      日本研究皮膚科学会 第 41 回年次学術大会・総会
    • Place of Presentation
      仙台
    • Year and Date
      2016-12-09
    • Related Report
      2016 Research-status Report
  • [Presentation] Involvement of opioid systems in itch-related behavior of imiquimod-induced psoriasis-like dermatitis model2016

    • Author(s)
      Nobuaki Takahashi, Mitsutoshi Tominaga, Yayoi Kamata, Yoshie Umehara, Hironori Matsuda, Yasushi Suga, Hideoki Ogawa, Kenji Takamori
    • Organizer
      日本研究皮膚科学会 第 41 回年次学術大会・総会
    • Place of Presentation
      仙台
    • Year and Date
      2016-12-09
    • Related Report
      2016 Research-status Report
  • [Presentation] ドラッグリポジショニングに向けたセマフォリン3A発現調節剤のin vitroスクリーニング2016

    • Author(s)
      鎌田弥生、冨永光俊、坂口安澄、梅原芳恵、髙森建二
    • Organizer
      第89回日本生化学会大会
    • Place of Presentation
      仙台
    • Year and Date
      2016-09-25
    • Related Report
      2016 Research-status Report
  • [Remarks] 研究:髙森グループ

    • URL

      http://www.juntendo.ac.jp/graduate/laboratory/labo/kankyo_igaku/k4_takamori.html

    • Related Report
      2017 Annual Research Report
  • [Remarks] かゆみと真剣勝負、かゆみの克服を目指して!

    • URL

      http://www.juntendo.ac.jp/graduate/laboratory/labo/kankyo_igaku/kayumi/

    • Related Report
      2017 Annual Research Report

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Published: 2016-04-21   Modified: 2019-03-29  

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