Fluctuation Magnetic Resonance Imaging in Brain Tumor

• Project/Area Number: 16K19227
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Multi-year Fund
• Research Field: Medical Physics and Radiological Technology
• Research Institution: Kanazawa University
• Principal Investigator: OHNO Naoki 金沢大学, 保健学系, 助教 (30642219)
• Project Period (FY): 2016-04-01 – 2019-03-31
• Project Status: Completed (Fiscal Year 2018)
• Budget Amount: ¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000); Fiscal Year 2018: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000); Fiscal Year 2017: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000); Fiscal Year 2016: ¥2,600,000 (Direct Cost: ¥2,000,000、Indirect Cost: ¥600,000)
• Keywords: MRI / 頭蓋内環境 / 灌流 / 水分子拡散 / 弾性 / 拡散 / 磁気共鳴画像 / 水分子揺動

Outline of Final Research Achievements

We developed a novel fluctuation magnetic resonance imaging which provides functional information on brain perfusion, restricted diffusion of water molecules, and water fluctuation. Our results verified the validity of these parameters in a brain phantom and healthy volunteers. We are working on clinical trials in brain tumor.

Academic Significance and Societal Importance of the Research Achievements

本手法は独自の撮像・解析法により揺動MRIに内在する灌流，水分子の制限拡散および揺動情報を一度に取得して統合的に評価することが可能である．また，通常のMRI 検査に１０分以内の撮像を加えるだけであり，被検者の負担は少なく，解析は申請者が開発したコンピュータプログラムによって完全自動化されるため，通常のMRI 検査に組み込むことは容易である．本手法で得られる各機能情報は脳腫瘍の組織形態および腫瘍細胞周囲を取り巻く微小環境の変化に関係することから，脳腫瘍の悪性度，進展度および治療効果の評価に有用となり得ると考える．

Research Products

• [Int'l Joint Research] University of Miami(米国)
• [Int'l Joint Research] University of Picardy Jules Verne(フランス)
• [Int'l Joint Research] University of Miami(米国)
• [Int'l Joint Research] University of Picardy Jules Verne(France)
• [Journal Article] Hemodynamically self-corrected ΔADC analysis in idiopathic normal pressure hydrocephalus (2019)
  • Author(s): Takatsuji-Nagaso M, Miyati T, Ohno N, Mase M, Kasai H, Shibamoto Y, Kobayashi S, Gabata T, Kitagawa K
  • Journal Title: The British Journal of Radiology Volume: 92 Issue: 1097 Pages: 20180553-20180553
  • DOI: 10.1259/bjr.20180553
  • Peer Reviewed
• [Journal Article] MRI-based assessment of acute effect of head-down tilt position on intracranial hemodynamics and hydrodynamics (2018)
  • Author(s): Ishida S, Miyati T, Ohno N, Hiratsuka S, Alperin N, Mase M, Gabata T
  • Journal Title: J Magn Reson Imaging Volume: 47 Issue: 2 Pages: 565-571
  • DOI: 10.1002/jmri.25781
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Analyses of Aqueductal Area and Cerebrospinal Fluid Flow-Velocity in Normal Pressure Hydrocephalus (2018)
  • Author(s): 平松勇樹，宮地利明，間瀬光人，大野直樹
  • Journal Title: Medical Imaging and Information Sciences Volume: 35 Issue: 1 Pages: 17-19
  • DOI: 10.11318/mii.35.17
  • NAID: 130006565451
  • ISSN: 0910-1543, 1880-4977
  • Peer Reviewed
• [Journal Article] Correction of the Blood Flow Effect Using Perfusion-Related Diffusion for Brain-Fluctuation MRI in Healthy Volunteers: a Preliminary Study (2017)
  • Author(s): Takatsuji M, Miyati T, Ohno N, Noda T, Mase M, Gabata T
  • Journal Title: Medical Imaging and Information Sciences Volume: 34 Issue: 3 Pages: 132-135
  • DOI: 10.11318/mii.34.132
  • NAID: 130006146261
  • ISSN: 0910-1543, 1880-4977
  • Peer Reviewed / Open Access
• [Journal Article] Quantitation of Venous Blood Flow in Gravity MRI: A Phantom Study (2017)
  • Author(s): Ohno N, Miyati T, Hiramatsu Y, Yamasaki M
  • Journal Title: Medical Imaging and Information Sciences Volume: 34 Issue: 3 Pages: 141-143
  • DOI: 10.11318/mii.34.141
  • NAID: 130006146259
  • ISSN: 0910-1543, 1880-4977
  • Peer Reviewed / Open Access
• [Journal Article] Development of a Cranial Phantom for Assessing Perfusion, Diffusion, and Biomechanics (2017)
  • Author(s): Ohno N, Miyati T, Chigusa T, Usui H, Ishida S, Hiramatsu Y, Kobayashi S, Gabata T, Alperin N
  • Journal Title: Medical Physics Volume: in press Issue: 5 Pages: 1646-1654
  • DOI: 10.1002/mp.12182
  • Peer Reviewed / Int'l Joint Research / Acknowledgement Compliant
• [Journal Article] Water and Lipid Diffusion MRI using Chemical Shift Displacement-based Separation of Lipid Tissue (SPLIT) (2017)
  • Author(s): Ohno N, Kan H, Miyati T, Aoki T, Ishida S, Gabata T
  • Journal Title: Magnetic Resonance Imaging Volume: 16 Pages: 144-148
  • DOI: 10.1016/j.mri.2017.02.006
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Journal Article] 牽引が拘縮改善のための手関節運動に与える影響のMRI による検証 (2017)
  • Author(s): 立矢 宏，折坂康介，土田博貴，真田茂，西村誠次，多田 薫，川嶋広貴，堀江翔，大野直樹
  • Journal Title: 日本機械学会論文集 Volume: 印刷中
  • NAID: 130005612147
  • Peer Reviewed
• [Journal Article] Reply to: On the perils of multiexponential fitting of diffusion MR data (2016)
  • Author(s): Ohno N, Miyati T, Kobayashi S, Gabata T
  • Journal Title: Journal of Magnetic Resonance Imaging Volume: 45 Issue: 5 Pages: 1548-1548
  • DOI: 10.1002/jmri.25495
• [Journal Article] Hemodynamic analysis of cerebral water fluctuation in brain using diffusion and perfusion MRI (2016)
  • Author(s): Kitanaka A, Miyati T, Ohno N, Kan H, Mase M, Kobayashi S, Gabata T
  • Journal Title: Medical Imaging and Information Sciences Volume: 33 Pages: 52-60
  • Peer Reviewed
• [Presentation] Investigation of the Effect of Body Posture on Dynamic ADC Change during Cardiac Cycle in Human Brain (2018)
  • Author(s): Ohno N, Miyati T, Uehara M, Hiramatsu Y, Okamoto R, Mase M, Kobayashi S, Gabata T
  • Organizer: Joint Annual Meeting ISMRM-ESMRMB
  • Int'l Joint Research
• [Presentation] The Effect of Respiration on Apparent Diffusion Coefficient of the Brain (2018)
  • Author(s): Ohno N, Miyati T, Hiramatsu Y, Shimizu R, Mase M, Kobayashi S, Gabata T
  • Organizer: Joint Annual Meeting ISMRM-ESMRMB
  • Int'l Joint Research
• [Presentation] Effect of Body Posture on Water Fluctuation in Brain (2018)
  • Author(s): Uehara M, Miyati T, Ohno N, Hiramatsu Y, Okamoto R, Mase M, Kobayashi S, Gabata T
  • Organizer: The 46th Annual Meeting of the Japanese Society for Magnetic Resonance in Medicine (JSMRM 2018)
  • Int'l Joint Research
• [Presentation] Dynamic ADC Analysis of the Brain in the Supine and Upright Postures (2018)
  • Author(s): Ohno N, Miyati T, Uehara M, Hiramatsu Y, Okamoto R, Mase M, Kobayashi S, Gabata T
  • Organizer: RSNA2018 104th Scientific Assembly and Annual Meeting
  • Int'l Joint Research
• [Presentation] Dynamic ADC Change During Cardiac Cycle in Human Brain in Sleep State (2017)
  • Author(s): Yamamori R, Miyati T, Ohno N, Hiramatsu Y, Kurita T, Miki S, Sekiya A, Hoshina Y, Gabata T
  • Organizer: ISMRM 25th Annual Meeting & Exhibition
  • Int'l Joint Research
• [Presentation] Chemical Shift Displacement and Recovery-Based Simultaneous Water and Lipid Imaging for Quantitative Multiparametric MRI (2017)
  • Author(s): Ohno N, Miyati T, Suzuki S, Kan H, Aoki T, Nakamura Y, Hiramatsu Y, Gabata T
  • Organizer: ISMRM 25th Annual Meeting & Exhibition
  • Int'l Joint Research
• [Presentation] Apparent Diffusion Coefficient in Brain is Affected by Respiration (2017)
  • Author(s): Hiramatsu Y, Miyati T, Ohno N, Mase M, Kobayashi S, Gabata T
  • Organizer: 103rd RSNA Annual Meeting
  • Int'l Joint Research
• [Presentation] Effect of Sleep State on ADC Change during Cardiac Cycle in the Human Brain (2017)
  • Author(s): Hiramatsu Y, Miyati T, Yamamori R, Ohno N, Kurita T, Miki S, Sekiya A, Hoshina Y, Gabata T
  • Organizer: 103rd RSNA Annual Meeting
  • Int'l Joint Research
• [Presentation] Change in ADC during cardiac cycle in idiopathic normal pressure hydrocephalus decreases with shunt surgery (2016)
  • Author(s): Yamamori R, Miyati T, Ohno N, Mase M, Osawa T, Ishida S, Kasai H, Shibamoto Y
  • Organizer: 102nd RSNA Meeting
  • Place of Presentation: Chicago (USA)
  • Year and Date: 2016-11-27
  • Int'l Joint Research
• [Presentation] Super-hybrid quantitative MRI using displacement and recovery-based water-lipid separation imaging (2016)
  • Author(s): Suzuki S, Miyati T, Ohno N, Kan H, Aoki T, Hiramatsu Y, Nakamura Y, Gabata T
  • Organizer: 102nd RSNA Meeting
  • Place of Presentation: Chicago (USA)
  • Year and Date: 2016-11-27
  • Int'l Joint Research
• [Presentation] Self-correction of blood flow effect for fluctuation MRI in idiopathic normal pressure hydrocephalus (2016)
  • Author(s): Ohno N, Miyati T, Takatsuji M, Mase M, Osawa T, Kan H, Shibamoto Y, Gabata T
  • Organizer: 102nd RSNA Meeting
  • Place of Presentation: Chicago (USA)
  • Year and Date: 2016-11-27
  • Int'l Joint Research
• [Presentation] Optimal strategy for measuring intraventricular temperature using acceleration motion compensation DWI (2016)
  • Author(s): Shibukawa S, Ohno N, Miyati T, Takano S, Niwa T, Ogino T, Horie T, Kajihara N
  • Organizer: 第44回日本磁気共鳴医学会大会
  • Place of Presentation: 大宮ソニックシティ（埼玉県さいたま市）
  • Year and Date: 2016-09-09
• [Presentation] Acceleration motion compensation DWI for measuring intraventricular temperature (2016)
  • Author(s): Shibukawa S, Miyati T, Ohno N, Niwa T, Imai Y, Ogino T, Muro I
  • Organizer: ISMRM 24th Scientific Meeting and Exhibition
  • Place of Presentation: Singapore
  • Year and Date: 2016-05-07
  • Int'l Joint Research
• [Presentation] Quantification of the effect of head-down tilt posture on intracranial condition using MRI (2016)
  • Author(s): Ohno N, Miyati T, Hiratsuka S, Ishida S, Alperin N, Kobayashi S, Gabata T
  • Organizer: ISMRM 24th Scientific Meeting and Exhibition
  • Place of Presentation: Singapore
  • Year and Date: 2016-05-07
  • Int'l Joint Research
• [Presentation] Triexponential diffusion analysis in breast cancer (2016)
  • Author(s): Ohno M, Miyati T, Ohno N, Kawashima H, Kozaka K, Matsuura Y, Gabata T
  • Organizer: ISMRM 24th Scientific Meeting and Exhibition
  • Place of Presentation: Singapore
  • Year and Date: 2016-05-07
  • Int'l Joint Research
• [Presentation] Hemodynamic-independent fluctuation MRI using self-correction in idiopathic normal pressure hydrocephalus (2016)
  • Author(s): Ohno N, Miyati T, Takatsuji M, Mase M, Osawa T, Shibamoto Y
  • Organizer: ISMRM 24th Scientific Meeting and Exhibition
  • Place of Presentation: Singapore
  • Year and Date: 2016-05-07
  • Int'l Joint Research
• [Presentation] Quantitative evaluation of mapping of magnetic distortion due to metallic materials (2016)
  • Author(s): Kaneda T, Oshinomi K, Ohno N, Miyati T, Yamamoto T
  • Organizer: ISMRM 24th Scientific Meeting and Exhibition
  • Place of Presentation: Singapore
  • Year and Date: 2016-05-07
  • Int'l Joint Research
• [Presentation] ΔADC in idiopathic normal pressure hydrocephalus after shunt surgery (2016)
  • Author(s): Yamamori R, Miyati T, Ohno N, Mase M, Osawa T, Ishida S, Kan H, Arai N, Kasai H, Shibamoto Y
  • Organizer: ISMRM 24th Scientific Meeting and Exhibition
  • Place of Presentation: Singapore
  • Year and Date: 2016-05-07
  • Int'l Joint Research
• [Presentation] 加速度補正型傾斜磁場を用いたDWIによる脳温測定の検討 (2016)
  • Author(s): 渋川周平，宮地利明，高野晋，大野直樹，丹羽徹，荻野徹男，室伊三男
  • Organizer: 第72回日本放射線技術学会総会学術大会
  • Place of Presentation: パシフィコ横浜（神奈川県横浜市）
  • Year and Date: 2016-04-14
• [Remarks] 金沢大学医薬保健研究域保健学系宮地研究室ホームページ
  • URL: http://miyatilab.w3.kanazawa-u.ac.jp/