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Fluctuation Magnetic Resonance Imaging in Brain Tumor

Research Project

Project/Area Number 16K19227
Research Category

Grant-in-Aid for Young Scientists (B)

Allocation TypeMulti-year Fund
Research Field Medical Physics and Radiological Technology
Research InstitutionKanazawa University

Principal Investigator

OHNO Naoki  金沢大学, 保健学系, 助教 (30642219)

Project Period (FY) 2016-04-01 – 2019-03-31
Project Status Completed (Fiscal Year 2018)
Budget Amount *help
¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000)
Fiscal Year 2018: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000)
Fiscal Year 2017: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000)
Fiscal Year 2016: ¥2,600,000 (Direct Cost: ¥2,000,000、Indirect Cost: ¥600,000)
KeywordsMRI / 頭蓋内環境 / 灌流 / 水分子拡散 / 弾性 / 拡散 / 磁気共鳴画像 / 水分子揺動
Outline of Final Research Achievements

We developed a novel fluctuation magnetic resonance imaging which provides functional information on brain perfusion, restricted diffusion of water molecules, and water fluctuation. Our results verified the validity of these parameters in a brain phantom and healthy volunteers. We are working on clinical trials in brain tumor.

Academic Significance and Societal Importance of the Research Achievements

本手法は独自の撮像・解析法により揺動MRIに内在する灌流,水分子の制限拡散および揺動情報を一度に取得して統合的に評価することが可能である.また,通常のMRI 検査に10分以内の撮像を加えるだけであり,被検者の負担は少なく,解析は申請者が開発したコンピュータプログラムによって完全自動化されるため,通常のMRI 検査に組み込むことは容易である.本手法で得られる各機能情報は脳腫瘍の組織形態および腫瘍細胞周囲を取り巻く微小環境の変化に関係することから,脳腫瘍の悪性度,進展度および治療効果の評価に有用となり得ると考える.

Report

(4 results)
  • 2018 Annual Research Report   Final Research Report ( PDF )
  • 2017 Research-status Report
  • 2016 Research-status Report
  • Research Products

    (34 results)

All 2019 2018 2017 2016 Other

All Int'l Joint Research (4 results) Journal Article (10 results) (of which Int'l Joint Research: 2 results,  Peer Reviewed: 9 results,  Open Access: 4 results,  Acknowledgement Compliant: 2 results) Presentation (19 results) (of which Int'l Joint Research: 17 results) Remarks (1 results)

  • [Int'l Joint Research] University of Miami(米国)

    • Related Report
      2018 Annual Research Report
  • [Int'l Joint Research] University of Picardy Jules Verne(フランス)

    • Related Report
      2018 Annual Research Report
  • [Int'l Joint Research] University of Miami(米国)

    • Related Report
      2017 Research-status Report
  • [Int'l Joint Research] University of Picardy Jules Verne(France)

    • Related Report
      2017 Research-status Report
  • [Journal Article] Hemodynamically self-corrected ΔADC analysis in idiopathic normal pressure hydrocephalus2019

    • Author(s)
      Takatsuji-Nagaso M, Miyati T, Ohno N, Mase M, Kasai H, Shibamoto Y, Kobayashi S, Gabata T, Kitagawa K
    • Journal Title

      The British Journal of Radiology

      Volume: 92 Issue: 1097 Pages: 20180553-20180553

    • DOI

      10.1259/bjr.20180553

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed
  • [Journal Article] MRI-based assessment of acute effect of head-down tilt position on intracranial hemodynamics and hydrodynamics2018

    • Author(s)
      Ishida S, Miyati T, Ohno N, Hiratsuka S, Alperin N, Mase M, Gabata T
    • Journal Title

      J Magn Reson Imaging

      Volume: 47 Issue: 2 Pages: 565-571

    • DOI

      10.1002/jmri.25781

    • Related Report
      2017 Research-status Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Analyses of Aqueductal Area and Cerebrospinal Fluid Flow-Velocity in Normal Pressure Hydrocephalus2018

    • Author(s)
      平松勇樹,宮地利明,間瀬光人,大野直樹
    • Journal Title

      Medical Imaging and Information Sciences

      Volume: 35 Issue: 1 Pages: 17-19

    • DOI

      10.11318/mii.35.17

    • NAID

      130006565451

    • ISSN
      0910-1543, 1880-4977
    • Related Report
      2017 Research-status Report
    • Peer Reviewed
  • [Journal Article] Correction of the Blood Flow Effect Using Perfusion-Related Diffusion for Brain-Fluctuation MRI in Healthy Volunteers: a Preliminary Study2017

    • Author(s)
      Takatsuji M, Miyati T, Ohno N, Noda T, Mase M, Gabata T
    • Journal Title

      Medical Imaging and Information Sciences

      Volume: 34 Issue: 3 Pages: 132-135

    • DOI

      10.11318/mii.34.132

    • NAID

      130006146261

    • ISSN
      0910-1543, 1880-4977
    • Related Report
      2017 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Quantitation of Venous Blood Flow in Gravity MRI: A Phantom Study2017

    • Author(s)
      Ohno N, Miyati T, Hiramatsu Y, Yamasaki M
    • Journal Title

      Medical Imaging and Information Sciences

      Volume: 34 Issue: 3 Pages: 141-143

    • DOI

      10.11318/mii.34.141

    • NAID

      130006146259

    • ISSN
      0910-1543, 1880-4977
    • Related Report
      2017 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Development of a Cranial Phantom for Assessing Perfusion, Diffusion, and Biomechanics2017

    • Author(s)
      Ohno N, Miyati T, Chigusa T, Usui H, Ishida S, Hiramatsu Y, Kobayashi S, Gabata T, Alperin N
    • Journal Title

      Medical Physics

      Volume: in press Issue: 5 Pages: 1646-1654

    • DOI

      10.1002/mp.12182

    • Related Report
      2016 Research-status Report
    • Peer Reviewed / Int'l Joint Research / Acknowledgement Compliant
  • [Journal Article] Water and Lipid Diffusion MRI using Chemical Shift Displacement-based Separation of Lipid Tissue (SPLIT)2017

    • Author(s)
      Ohno N, Kan H, Miyati T, Aoki T, Ishida S, Gabata T
    • Journal Title

      Magnetic Resonance Imaging

      Volume: 16 Pages: 144-148

    • DOI

      10.1016/j.mri.2017.02.006

    • Related Report
      2016 Research-status Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] 牽引が拘縮改善のための手関節運動に与える影響のMRI による検証2017

    • Author(s)
      立矢 宏,折坂康介,土田博貴,真田茂,西村誠次,多田 薫,川嶋広貴,堀江翔,大野直樹
    • Journal Title

      日本機械学会論文集

      Volume: 印刷中

    • NAID

      130005612147

    • Related Report
      2016 Research-status Report
    • Peer Reviewed
  • [Journal Article] Reply to: On the perils of multiexponential fitting of diffusion MR data2016

    • Author(s)
      Ohno N, Miyati T, Kobayashi S, Gabata T
    • Journal Title

      Journal of Magnetic Resonance Imaging

      Volume: 45 Issue: 5 Pages: 1548-1548

    • DOI

      10.1002/jmri.25495

    • Related Report
      2016 Research-status Report
  • [Journal Article] Hemodynamic analysis of cerebral water fluctuation in brain using diffusion and perfusion MRI2016

    • Author(s)
      Kitanaka A, Miyati T, Ohno N, Kan H, Mase M, Kobayashi S, Gabata T
    • Journal Title

      Medical Imaging and Information Sciences

      Volume: 33 Pages: 52-60

    • Related Report
      2016 Research-status Report
    • Peer Reviewed
  • [Presentation] Investigation of the Effect of Body Posture on Dynamic ADC Change during Cardiac Cycle in Human Brain2018

    • Author(s)
      Ohno N, Miyati T, Uehara M, Hiramatsu Y, Okamoto R, Mase M, Kobayashi S, Gabata T
    • Organizer
      Joint Annual Meeting ISMRM-ESMRMB
    • Related Report
      2018 Annual Research Report
    • Int'l Joint Research
  • [Presentation] The Effect of Respiration on Apparent Diffusion Coefficient of the Brain2018

    • Author(s)
      Ohno N, Miyati T, Hiramatsu Y, Shimizu R, Mase M, Kobayashi S, Gabata T
    • Organizer
      Joint Annual Meeting ISMRM-ESMRMB
    • Related Report
      2018 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Effect of Body Posture on Water Fluctuation in Brain2018

    • Author(s)
      Uehara M, Miyati T, Ohno N, Hiramatsu Y, Okamoto R, Mase M, Kobayashi S, Gabata T
    • Organizer
      The 46th Annual Meeting of the Japanese Society for Magnetic Resonance in Medicine (JSMRM 2018)
    • Related Report
      2018 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Dynamic ADC Analysis of the Brain in the Supine and Upright Postures2018

    • Author(s)
      Ohno N, Miyati T, Uehara M, Hiramatsu Y, Okamoto R, Mase M, Kobayashi S, Gabata T
    • Organizer
      RSNA2018 104th Scientific Assembly and Annual Meeting
    • Related Report
      2018 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Dynamic ADC Change During Cardiac Cycle in Human Brain in Sleep State2017

    • Author(s)
      Yamamori R, Miyati T, Ohno N, Hiramatsu Y, Kurita T, Miki S, Sekiya A, Hoshina Y, Gabata T
    • Organizer
      ISMRM 25th Annual Meeting & Exhibition
    • Related Report
      2017 Research-status Report
    • Int'l Joint Research
  • [Presentation] Chemical Shift Displacement and Recovery-Based Simultaneous Water and Lipid Imaging for Quantitative Multiparametric MRI2017

    • Author(s)
      Ohno N, Miyati T, Suzuki S, Kan H, Aoki T, Nakamura Y, Hiramatsu Y, Gabata T
    • Organizer
      ISMRM 25th Annual Meeting & Exhibition
    • Related Report
      2017 Research-status Report
    • Int'l Joint Research
  • [Presentation] Apparent Diffusion Coefficient in Brain is Affected by Respiration2017

    • Author(s)
      Hiramatsu Y, Miyati T, Ohno N, Mase M, Kobayashi S, Gabata T
    • Organizer
      103rd RSNA Annual Meeting
    • Related Report
      2017 Research-status Report
    • Int'l Joint Research
  • [Presentation] Effect of Sleep State on ADC Change during Cardiac Cycle in the Human Brain2017

    • Author(s)
      Hiramatsu Y, Miyati T, Yamamori R, Ohno N, Kurita T, Miki S, Sekiya A, Hoshina Y, Gabata T
    • Organizer
      103rd RSNA Annual Meeting
    • Related Report
      2017 Research-status Report
    • Int'l Joint Research
  • [Presentation] Change in ADC during cardiac cycle in idiopathic normal pressure hydrocephalus decreases with shunt surgery2016

    • Author(s)
      Yamamori R, Miyati T, Ohno N, Mase M, Osawa T, Ishida S, Kasai H, Shibamoto Y
    • Organizer
      102nd RSNA Meeting
    • Place of Presentation
      Chicago (USA)
    • Year and Date
      2016-11-27
    • Related Report
      2016 Research-status Report
    • Int'l Joint Research
  • [Presentation] Super-hybrid quantitative MRI using displacement and recovery-based water-lipid separation imaging2016

    • Author(s)
      Suzuki S, Miyati T, Ohno N, Kan H, Aoki T, Hiramatsu Y, Nakamura Y, Gabata T
    • Organizer
      102nd RSNA Meeting
    • Place of Presentation
      Chicago (USA)
    • Year and Date
      2016-11-27
    • Related Report
      2016 Research-status Report
    • Int'l Joint Research
  • [Presentation] Self-correction of blood flow effect for fluctuation MRI in idiopathic normal pressure hydrocephalus2016

    • Author(s)
      Ohno N, Miyati T, Takatsuji M, Mase M, Osawa T, Kan H, Shibamoto Y, Gabata T
    • Organizer
      102nd RSNA Meeting
    • Place of Presentation
      Chicago (USA)
    • Year and Date
      2016-11-27
    • Related Report
      2016 Research-status Report
    • Int'l Joint Research
  • [Presentation] Optimal strategy for measuring intraventricular temperature using acceleration motion compensation DWI2016

    • Author(s)
      Shibukawa S, Ohno N, Miyati T, Takano S, Niwa T, Ogino T, Horie T, Kajihara N
    • Organizer
      第44回日本磁気共鳴医学会大会
    • Place of Presentation
      大宮ソニックシティ(埼玉県さいたま市)
    • Year and Date
      2016-09-09
    • Related Report
      2016 Research-status Report
  • [Presentation] Acceleration motion compensation DWI for measuring intraventricular temperature2016

    • Author(s)
      Shibukawa S, Miyati T, Ohno N, Niwa T, Imai Y, Ogino T, Muro I
    • Organizer
      ISMRM 24th Scientific Meeting and Exhibition
    • Place of Presentation
      Singapore
    • Year and Date
      2016-05-07
    • Related Report
      2016 Research-status Report
    • Int'l Joint Research
  • [Presentation] Quantification of the effect of head-down tilt posture on intracranial condition using MRI2016

    • Author(s)
      Ohno N, Miyati T, Hiratsuka S, Ishida S, Alperin N, Kobayashi S, Gabata T
    • Organizer
      ISMRM 24th Scientific Meeting and Exhibition
    • Place of Presentation
      Singapore
    • Year and Date
      2016-05-07
    • Related Report
      2016 Research-status Report
    • Int'l Joint Research
  • [Presentation] Triexponential diffusion analysis in breast cancer2016

    • Author(s)
      Ohno M, Miyati T, Ohno N, Kawashima H, Kozaka K, Matsuura Y, Gabata T
    • Organizer
      ISMRM 24th Scientific Meeting and Exhibition
    • Place of Presentation
      Singapore
    • Year and Date
      2016-05-07
    • Related Report
      2016 Research-status Report
    • Int'l Joint Research
  • [Presentation] Hemodynamic-independent fluctuation MRI using self-correction in idiopathic normal pressure hydrocephalus2016

    • Author(s)
      Ohno N, Miyati T, Takatsuji M, Mase M, Osawa T, Shibamoto Y
    • Organizer
      ISMRM 24th Scientific Meeting and Exhibition
    • Place of Presentation
      Singapore
    • Year and Date
      2016-05-07
    • Related Report
      2016 Research-status Report
    • Int'l Joint Research
  • [Presentation] Quantitative evaluation of mapping of magnetic distortion due to metallic materials2016

    • Author(s)
      Kaneda T, Oshinomi K, Ohno N, Miyati T, Yamamoto T
    • Organizer
      ISMRM 24th Scientific Meeting and Exhibition
    • Place of Presentation
      Singapore
    • Year and Date
      2016-05-07
    • Related Report
      2016 Research-status Report
    • Int'l Joint Research
  • [Presentation] ΔADC in idiopathic normal pressure hydrocephalus after shunt surgery2016

    • Author(s)
      Yamamori R, Miyati T, Ohno N, Mase M, Osawa T, Ishida S, Kan H, Arai N, Kasai H, Shibamoto Y
    • Organizer
      ISMRM 24th Scientific Meeting and Exhibition
    • Place of Presentation
      Singapore
    • Year and Date
      2016-05-07
    • Related Report
      2016 Research-status Report
    • Int'l Joint Research
  • [Presentation] 加速度補正型傾斜磁場を用いたDWIによる脳温測定の検討2016

    • Author(s)
      渋川周平,宮地利明,高野晋,大野直樹,丹羽徹,荻野徹男,室伊三男
    • Organizer
      第72回日本放射線技術学会総会学術大会
    • Place of Presentation
      パシフィコ横浜(神奈川県横浜市)
    • Year and Date
      2016-04-14
    • Related Report
      2016 Research-status Report
  • [Remarks] 金沢大学医薬保健研究域保健学系宮地研究室ホームページ

    • URL

      http://miyatilab.w3.kanazawa-u.ac.jp/

    • Related Report
      2018 Annual Research Report 2017 Research-status Report 2016 Research-status Report

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Published: 2016-04-21   Modified: 2022-02-21  

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