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Automatic Contrast Agent Extraction System with Dual Energy CT

Research Project

Project/Area Number 16K19231
Research Category

Grant-in-Aid for Young Scientists (B)

Allocation TypeMulti-year Fund
Research Field Medical Physics and Radiological Technology
Research InstitutionHiroshima University

Principal Investigator

Kawahara Daisuke  広島大学, 病院(医), 診療放射線技師 (20630461)

Research Collaborator TANAKA Sodai  
Project Period (FY) 2016-04-01 – 2019-03-31
Project Status Completed (Fiscal Year 2018)
Budget Amount *help
¥3,380,000 (Direct Cost: ¥2,600,000、Indirect Cost: ¥780,000)
Fiscal Year 2018: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000)
Fiscal Year 2017: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2016: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Keywords放射線治療 / 治療計画 / 造影剤 / 線量計算 / Dual energy CT / 電子密度 / 単色X線CT値 / モンテカルロ計算 / 実効原子番号 / 医療・福祉 / 放射線 / X線
Outline of Final Research Achievements

In dual-energy CT (DECT), various information such as electron density, effective atomic number, and monochromatic X-ray CT value can be obtained. Using this information, we created a contrast agent map. And we constructed a system that allows us to identify the region where the contrast agent is present from the image and to assign the concentration accurately. The dose difference at 2 mg / ml, which is 3% or more of the contrast agent identification method, was within 2% and was not a significant difference. Furthermore, it was suggested that a dose calculation system incorporating a contrast agent identification method should be used if the contrast agent is contained at particularly high concentrations. We will study the results of this research so that it can be generalized, and promote the spread as part of a treatment planning system for high precision radiation therapy.

Academic Significance and Societal Importance of the Research Achievements

本研究では、造影剤を使用して検査(CT)を行った場合に画像上における造影剤で病変が白く染まった領域を抽出可能になります。これによって腫瘍のみをしっかりと把握できます。放射線治療においては病変領域に対して放射線を照射する領域を設定しますが、本造影剤特定システムを使用することで半自動的に腫瘍のみを設定でき、さらに造影剤が含まれる領域は人体に存在する物質とは異なるため造影剤として割り当てて計算を行わなければ線量差が生じてしまいます。本システムを使用し造影剤領域をしっかりと判定できれば正確に物質を割り当てて計算が可能となり、より正確かつ適切な線量投与が可能となります。

Report

(4 results)
  • 2018 Annual Research Report   Final Research Report ( PDF )
  • 2017 Research-status Report
  • 2016 Research-status Report
  • Research Products

    (18 results)

All 2018 2017 2016

All Journal Article (7 results) (of which Peer Reviewed: 7 results) Presentation (10 results) (of which Int'l Joint Research: 5 results) Funded Workshop (1 results)

  • [Journal Article] Automatic contrast medium extraction system using electron density data with dual-energy CT2018

    • Author(s)
      Kawahara D, Ozawa S, Tanaka S, Yokomachi K, Higaki T, Saito A, Miki K, Fujioka C, Ohno Y, Ohno Y, Kimura T, Murakami Y, Nagata Y
    • Journal Title

      The British Journal of Radiology

      Volume: 91 Issue: 1090 Pages: 1090-1090

    • DOI

      10.1259/bjr.20180396

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Energy spectrum and dose enhancement due to the depth of the Lipiodol position using flattened and unflattened beams2018

    • Author(s)
      Kawahara D, Ozawa S, Saito A, Kimura T, Suzuki T, Tsuneda M, Tanaka S, Hioki K, Nakashima T, Ohno Y, Murakami Y and Nagata Y
    • Journal Title

      Reports of Practical Oncology and Radiotherapy

      Volume: 23 Issue: 1 Pages: 50

    • DOI

      10.1016/j.rpor.2017.12.004

    • Related Report
      2018 Annual Research Report 2017 Research-status Report
    • Peer Reviewed
  • [Journal Article] Relative biological effectiveness study of Lipiodol based on microdosimetric-kinetic model2018

    • Author(s)
      Kawahara D, Nakano H, Ozawa S, Saito A, Kimura T, Suzuki T, Tsuneda M, Tanaka S, Ohno Y, Murakami Y and Nagata Y
    • Journal Title

      Physica Medica

      Volume: 46 Pages: 89

    • DOI

      10.1016/j.ejmp.2018.01.018

    • URL

      https://pure.teikyo.jp/en/publications/964a6a01-61c4-47cf-913a-29814786bf4e

    • Related Report
      2018 Annual Research Report 2017 Research-status Report
    • Peer Reviewed
  • [Journal Article] Tolerance levels of CT number to electron density table for photon beam in radiotherapy treatment planning system2018

    • Author(s)
      Nakao M, Kawahara D, Ozawa S, Yamada K, Hosono F, et al.
    • Journal Title

      Journal applied clinical medical physics

      Volume: 19 Issue: 1 Pages: 271

    • DOI

      10.1002/acm2.12226

    • Related Report
      2017 Research-status Report
    • Peer Reviewed
  • [Journal Article] Effect of secondary electron generation on dose enhancement in Lipiodol with and without a flattening filter2018

    • Author(s)
      Kawahara D, Ozawa S, Saito A, Kimura T, et al.
    • Journal Title

      Journal applied clinical medical physics

      Volume: 19 Issue: 2 Pages: 211

    • DOI

      10.1002/acm2.12282

    • Related Report
      2017 Research-status Report
    • Peer Reviewed
  • [Journal Article] Accuracy of the raw-data-based effective atomic numbers and monochromatic CT numbers for contrast medium with a dual-energy CT technique2017

    • Author(s)
      Kawahara D, Ozawa S, Yokomachi K, Tanaka S, et al.
    • Journal Title

      The British Journal of Radiology

      Volume: 91 Pages: 1082-1082

    • DOI

      10.1259/bjr.20170524

    • Related Report
      2018 Annual Research Report 2017 Research-status Report
    • Peer Reviewed
  • [Journal Article] Dosimetric impact of Lipiodol in stereotactic body radiation therapy on liver after trans-arterial chemoembolization:2017

    • Author(s)
      Kawahara D, Ozawa S, Saito A, Nishio T, et al.
    • Journal Title

      Medical Physics

      Volume: 44 Issue: 1 Pages: 342

    • DOI

      10.1002/mp.12028

    • URL

      https://pure.teikyo.jp/en/publications/9b1c6588-6f0f-4773-960b-a89ac022f26b

    • Related Report
      2017 Research-status Report
    • Peer Reviewed
  • [Presentation] Contrast medium extraction system using direct-electron density- CT number method and dual CT number method with Dual energy-CT2018

    • Author(s)
      Kawahara D, Ozawa S, Tanaka S, Yokomachi K, Higaki T, Saito A, Miki K, Fujioka C, Ohno Y, Ohno Y, Kimura T, Murakami Y, Nagata Y
    • Organizer
      The 3rd International Conference on Radiological Science and Technology (ICRST)
    • Related Report
      2018 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Contrast medium extraction method using raw-data based electron density with Dual energy-CT2018

    • Author(s)
      Kawahara D, Ozawa S, Tanaka S, Yokomachi K, Higaki T, Saito A, Miki K, Fujioka C, Ohno Y, Ohno Y, Kimura T, Murakami Y, Nagata Y
    • Organizer
      ESTRO37
    • Related Report
      2018 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Accuracy of the effective atomic numbers and theoretical monochromatic CT numbers for contrast medium with raw-data based dual-energy CT2018

    • Author(s)
      Kawahara D, Ozawa S, Tanaka S, Yokomachi K, Higaki T, Saito A, Miki K, Fujioka C, Ohno Y, Ohno Y, Kimura T, Murakami Y, Nagata Y
    • Organizer
      第74回日本放射線技術学会総会学術大会
    • Related Report
      2018 Annual Research Report
  • [Presentation] Relative biological effectiveness and relative dose-rate effect on Lipiodol based on the microdosimetric-kinetic model2018

    • Author(s)
      Kawahara D, Nakano H, Ozawa S, Saito A, Kimura T, Suzuki T, Tsuneda M, Tanaka S, Ohno Y, Murakami Y and Nagata Y
    • Organizer
      ESTRO37
    • Related Report
      2018 Annual Research Report
  • [Presentation] Dual Energy CT を用いた造影剤物質特定及び線量計算システム構築に向けた最適な造影剤抽出方法の検討2017

    • Author(s)
      河原大輔
    • Organizer
      第73回日本放射線技術学会
    • Place of Presentation
      パシフィコ横浜
    • Year and Date
      2017-04-12
    • Related Report
      2016 Research-status Report
  • [Presentation] Dual Energy CT を用いた造影剤物質特定及び線量計算システム構築に向けた最適な造影剤抽出方法の検討2017

    • Author(s)
      河原大輔、小澤修一、斎藤明登、田中創大、他。
    • Organizer
      第73回日本放射線技術学会総会
    • Related Report
      2017 Research-status Report
  • [Presentation] Iodine Extraction Method using Direct-Electron Density and CT value with Dual energy-CT2017

    • Author(s)
      D Kawahara, S Ozawa, T Nakashima, et al.
    • Organizer
      AAPM 59th Annual Meeting & Exhibition
    • Related Report
      2017 Research-status Report
    • Int'l Joint Research
  • [Presentation] Relative biological effectiveness study on Lipiodol based on the microdosimetric-kinetic model2017

    • Author(s)
      D Kawahara, S Ozawa, T Nakashima, et al.
    • Organizer
      8th Japan-Korea Joint Meeting on Medical Physics
    • Related Report
      2017 Research-status Report
    • Int'l Joint Research
  • [Presentation] Contrast medium extraction system using direct-electron density- CT number method and dual CT number method with Dual energy-CT2017

    • Author(s)
      D Kawahara, S Ozawa, T Nakashima, et al.
    • Organizer
      The 3rd International Conference on Radiological Science and Technology (ICRST)
    • Related Report
      2017 Research-status Report
    • Int'l Joint Research
  • [Presentation] Dual Energy CT を用いた造影剤物質特定及び線量計算システムの開発に向けて2016

    • Author(s)
      河原大輔
    • Organizer
      第16 回広島放射線治療研究会
    • Place of Presentation
      アークホテル広島
    • Related Report
      2016 Research-status Report
  • [Funded Workshop] AAPM 58th Annual Meeting & Exhibition2016

    • Place of Presentation
      ワシントン(USA)
    • Year and Date
      2016-07-31
    • Related Report
      2016 Research-status Report

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Published: 2016-04-21   Modified: 2020-03-30  

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