| Project/Area Number |
16K19243
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Epidemiology and preventive medicine
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| Research Institution | Hokkaido University |
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Principal Investigator |
KOBAYASHI Sumitaka 北海道大学, 環境健康科学研究教育センター, 特任講師 (10733371)
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| Research Collaborator |
MIYASHITA Chihiro 北海道大学, 環境健康科学研究教育センター, 特任准教授 (70632389)
ARAKI Atsuko 北海道大学, 環境健康科学研究教育センター, 准教授 (00619885)
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| Project Period (FY) |
2016-04-01 – 2018-03-31
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| Project Status |
Completed (Fiscal Year 2017)
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| Budget Amount *help |
¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000)
Fiscal Year 2017: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Fiscal Year 2016: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
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| Keywords | 妊婦 / 胎児 / ダイオキシン類 / DNAメチル化 / エピゲノム / 遺伝環境交互作用 / 環境化学物質 / 公衆衛生学 / 社会医学 / 疫学 / ダイオキシン / 遺伝子多型 / 一塩基多型 |
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| Outline of Final Research Achievements |
Using prospective birth cohort, I examined an association between maternal dioxin levels in blood during pregnancy and genetic polymorphisms of genes encoded dioxin-metabolizing receptor and enzymes (aromatic hydrocarbon receptor [AHR], cytochrome P450 [CYP] 1A1, CYP1A2, CYP1B1, and glutathione S-transferase mu1 [GSTM1]) on levels of infant DNA methylation (insulin-like growth factor-2 [IGF-2], H19, and long interspersed nuclear element-1 [LINE-1]). None of maternal genotypes showed the effects of infant IGF-2, H19, and LINE-1 methylation levels for maternal dioxin levels during pregnancy. In conclusion, maternal genetic polymorphisms of genes encoded dioxin-metabolizing receptor and enzymes did not modify the association between maternal dioxin levels in blood during pregnancy and levels of infant IGF-2, H19, and LINE-1 methylation.
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