Does the distribution of muscle mass increase the risk of fracture independently of total muscle mass? A large scale cohort study of Japanese women

• Project/Area Number: 16K19263
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Multi-year Fund
• Research Field: Epidemiology and preventive medicine
• Research Institution: Kindai University
• Principal Investigator: TACHIKI Takahiro 近畿大学, 医学部, 助教 (10734650)
• Project Period (FY): 2016-04-01 – 2018-03-31
• Project Status: Completed (Fiscal Year 2017)
• Budget Amount: ¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000); Fiscal Year 2017: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000); Fiscal Year 2016: ¥3,250,000 (Direct Cost: ¥2,500,000、Indirect Cost: ¥750,000)
• Keywords: 筋量分布 / 骨折リスク / 地域在住女性 / コホート研究 / 骨折 / サルコペニア

Outline of Final Research Achievements

We examined whether the distribution of muscle mass increases the risk of fracture independently of total muscle mass in community-dwelling women. Five hundred seventy women were analyzed. The distribution of muscle mass was used as a predictor, and the incident vertebral fractures were used as an outcome. The lower limb muscle mass/total muscle mass ratio was significantly associated with incident vertebral fractures independently of total muscle mass (odds ratio 0.697 for 1SD decrease, 95%CI 0.500-0.970). Other muscle mass distribution index showed no significant association with incident vertebral fractures. The findings from the present study suggest that distribution of muscle mass is associated with fracture risk independently of total muscle mass.

Research Products

• [Journal Article] Relative Importance of Central and Peripheral Adiposities on Cardiometabolic Variables in Females: A Japanese Population-Based Study (2017)
  • Author(s): K Kouda, N Dongmei, J Tamaki, M Iki, T Tachiki, E Kajita, Y Nakatani, K Uenishi, S Kagamimori, Y Kagawa, H Yoneshima
  • Journal Title: J Clinical Densitometry Volume: 20 Issue: 1 Pages: 58-65
  • DOI: 10.1016/j.jocd.2016.04.004
  • Peer Reviewed / Open Access
• [Journal Article] Muscle strength is associated with bone health independently of muscle mass in postmenopausal women: the Japanese Population-based Osteoporosis study (2017)
  • Author(s): T Tachiki, K Kouda, N Dongmei, J Tamaki, M Iki, J Kitagawa, N Takahira, Y Sato, E Kajita, Y Fujita, A Yura, S Kagamimori
  • Journal Title: J. Bone Mineral Metabolism Volume: - Issue: 1 Pages: 1-7
  • DOI: 10.1007/s00774-017-0895-7
  • Peer Reviewed / Open Access
• [Presentation] Walking steps correlated with bone mineral density at the femoral neck independently of muscle function in postmenopausal Japanese women (2018)
  • Author(s): Kitagawa J, Tachiki T, Iki M, Tamaki J, Kouda K, Sato Y, Kajita E, Takahira N, Kagamimori S, JPOS Study Group
  • Organizer: International Conference on Fraility & Sarcopenia Research 2018
• [Presentation] Daily physical activity is associated with smaller decrease in bone mineral density: evaluation using an objective activity measurement with a triaxial accelerometer in Japanese women (2017)
  • Author(s): Tachiki T, Iki M, Tamaki J, Kitagawa J, Kouda K, Sato Y, Kajita E, Takahira N, Kagamimori S
  • Organizer: IEA 2017 World Congress of Epidemiology
• [Presentation] Hand-grip strength as a predictor of site-specific osteoporotic fracture risk in postmenopausal women: The Japanese Population-based Osteoporosis (JPOS) Cohort Study (2017)
  • Author(s): Kamiya K, Kajita E, Tachiki T, Kouda K, Sato Y, Ikehara S, Tamaki J, Iki M, Kagamimori S
  • Organizer: IEA 2017 World Congress of Epidemiology
• [Presentation] Does DXA-image based hip geometry improve hip fracture prediction by bone mineral density? The Japanese Population-based Osteoporosis (JPOS) Cohort Study (2017)
  • Author(s): Iki M, DongMei N, Tamaki J, Sato Y, Tachiki T, Kouda K, Kajita E, Kagamimori S
  • Organizer: ECTS 2017: 44th European Calcified Tissue Society Congress
• [Remarks] JPOS研究（The JPOS Study)
  • URL: http://www.med.kindai.ac.jp/pubheal/jpos/index.html