The study about omega-3 fatty acids and their metabolites as preventive drugs for premature birth

• Project/Area Number: 16K19268
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Multi-year Fund
• Research Field: Hygiene and public health
• Research Institution: The University of Tokyo
• Principal Investigator: Yamashita Aki 東京大学, 医学部附属病院, 登録研究員 (00567448)
• Co-Investigator(Renkei-kenkyūsha): KAWANA Kei 日本大学, 医学部附属板橋病院・産婦人科, 主任教授 (60311627) ; NAGAMATSU Takeshi 東京大学, 医学部附属病院・産科女性診療科, 准教授 (60463858)
• Research Collaborator: SAMEJIMA Taiki ; MIMURA Nobuko ; INOUE Eri ; SATOU Masakazu
• Project Period (FY): 2016-04-01 – 2018-03-31
• Project Status: Completed (Fiscal Year 2017)
• Budget Amount: ¥4,030,000 (Direct Cost: ¥3,100,000、Indirect Cost: ¥930,000); Fiscal Year 2017: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000); Fiscal Year 2016: ¥3,120,000 (Direct Cost: ¥2,400,000、Indirect Cost: ¥720,000)
• Keywords: オメガ3脂肪酸 / 早産 / 炎症 / EPA / 18-HEPE / RvE3 / SLPI / レゾルビン / トランスレーショナルリサーチ / 栄養学 / 脂質 / 医療・福祉

Outline of Final Research Achievements

We conducted research aimed at clinically applying omega-3 fatty acids, such as EPA and DHA, which are rich in fish oils and the like, as a preventive drug for premature birth. Omega-3 fatty acids have an anti-inflammatory action and have shown to prevent inflammation-induced premature birth in a mouse model, and it has been suggested that the action of EPA is particularly important. Within this research period, we clarified the preventive effect and preliminary mechanism of preterm birth caused by EPA-derived metabolite 18-HEPE and downstream resolvin. In addition, for clinical application, clinical research to examine whether pregnant women with high premature birth risk are able to prevent premature birth by orally administering EPA preparation has started and is ongoing.

Research Products

• [Journal Article] オメガ3脂肪酸による早産予防 (2017)
  • Author(s): 原亜紀
  • Journal Title: 産婦人科の実際 Volume: 66 Pages: 13-15
• [Journal Article] Detachment from the primary site and suspension in ascites as the initial step in metabolic reprogramming and metastasis to the omentum in ovarian cancer (2017)
  • Author(s): Sato Masakazu、Kawana Kei、Adachi Katsuyuki、Fujimoto Asaha、Yoshida Mitsuyo、Nakamura Hiroe、Nishida Haruka、Inoue Tomoko、Taguchi Ayumi、Ogishima Juri、Eguchi Satoko、Yamashita Aki、Tomio Kensuke、Komatsu Atsushi、Wada?Hiraike Osamu、Oda Katsutoshi、Nagamatsu Takeshi、Osuga Yutaka、Fujii Tomoyuki
  • Journal Title: Oncology Letters Volume: 15 Pages: 1357-1361
  • DOI: 10.3892/ol.2017.7388
  • Peer Reviewed
• [Journal Article] Intracellular signaling entropy can be a biomarker for predicting the development of cervical intraepithelial neoplasia (2017)
  • Author(s): Sato Masakazu、Kawana Kei、Adachi Katsuyuki、Fujimoto Asaha、Yoshida Mitsuyo、Nakamura Hiroe、Nishida Haruka、Inoue Tomoko、Taguchi Ayumi、Ogishima Juri、Eguchi Satoko、Yamashita Aki、Tomio Kensuke、Wada-Hiraike Osamu、Oda Katsutoshi、Nagamatsu Takeshi、Osuga Yutaka、Fujii Tomoyuki
  • Journal Title: PLOS ONE Volume: 12 Issue: 4 Pages: e0176353-e0176353
  • DOI: 10.1371/journal.pone.0176353
  • Peer Reviewed
• [Journal Article] Regeneration of cervical reserve cell-like cells from human induced pluripotent stem cells (iPSCs): A new approach to finding targets for cervical cancer stem cell treatment (2017)
  • Author(s): Sato M, Kawana K, Adachi K, Fujimoto A, Yoshida M, Nakamura H, Nishida H, Inoue T, Taguchi A, Ogishima J, Eguchi S, Yamashita A, Tomio K, Wada-Hiraike O, Oda K, Nagamatsu T, Osuga Y, Fujii T,
  • Journal Title: Oncotarget Volume: - Issue: 25 Pages: 000-0000
  • DOI: 10.18632/oncotarget.16783
  • Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
• [Journal Article] Low uptake of fluorodeoxyglucose in positron emission tomography/computed tomography in ovarian clear cell carcinoma may reflect glutaminolysis of its cancer stem cell-like properties, (2017)
  • Author(s): Sato M, Kawana K, Adachi K, Fujimoto A, Taguchi A, Fujikawa T, Yoshida M, Nakamura H, Nishida H, Inoue T, Ogishima J, Eguchi S, Yamashita A, Tomio K, Arimoto T, Wada-Hiraike Osamu, Oda K, Nagamatsu T, Osuga Y, Fujii T
  • Journal Title: Oncol Reports Volume: 37(3) Issue: 3 Pages: 1883-1888
  • DOI: 10.3892/or.2017.5398
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Journal Article] Targeting glutamine metabolism and focal adhesion kinase additively inhibits the mammalian target of the rapamycin pathway in spheroid cancer stem-like properties of ovarian clear cell carcinoma (2016)
  • Author(s): Sato M, Kawana K, Adachi K, Fujimoto A, Yoshida M, Nakamura H, Nishida H, Inoue T, Taguchi A, Ogishima J, Eguchi S, Yamashita A, Tomio K, Wada-Hiraike O, Oda K, Nagamatsu T, Osuga Y , Fujii T,
  • Journal Title: Int J Oncol Volume: 50（4） Issue: 4 Pages: 1431-1438
  • DOI: 10.3892/ijo.2017.3891
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Presentation] オメガ３脂肪酸の摂取と早産予防効果について (2017)
  • Author(s): 原(山下) 亜紀
  • Organizer: 第35回東京母性衛生学会