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Combined effects of components of PM2.5 on early stage of biological and immune responses.

Research Project

Project/Area Number 16K19272
Research Category

Grant-in-Aid for Young Scientists (B)

Allocation TypeMulti-year Fund
Research Field Hygiene and public health
Research InstitutionKyoto University

Principal Investigator

Honda Akiko  京都大学, 工学研究科, 助教 (20454324)

Project Period (FY) 2016-04-01 – 2018-03-31
Project Status Completed (Fiscal Year 2017)
Budget Amount *help
¥4,030,000 (Direct Cost: ¥3,100,000、Indirect Cost: ¥930,000)
Fiscal Year 2017: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
Fiscal Year 2016: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
KeywordsPM2.5 / アレルギー / 気管支喘息 / 複合影響 / PM2.5成分 / 環境 / アレルギー・ぜんそく
Outline of Final Research Achievements

We investigated combined effects of components of PM2.5 on respiratory and immune cells to elucidate the underlying mechanisms by which PM2.5 lead to the development and/or exacerbation of allergic diseases such as asthma. This study indicates components of PM2.5 can contribute to the development and/or exacerbation of asthma by disruption of respiratory and immune systems independently or synergistically.

Report

(3 results)
  • 2017 Annual Research Report   Final Research Report ( PDF )
  • 2016 Research-status Report
  • Research Products

    (1 results)

All 2017

All Journal Article (1 results) (of which Peer Reviewed: 1 results)

  • [Journal Article] Synergic effects of 9,10-phenanthrenequinone and cadmium on pro-inflammatory responses in airway epithelial cells2017

    • Author(s)
      Akiko Honda, Pratiti Home Chowdhury, Sho Ito, Hitoshi Okano, Toshinori Onishi, Yusuke Kawaryu, Kayo Ueda, Hirohisa Takano
    • Journal Title

      Environmental Toxicology and Pharmacology

      Volume: 52 Pages: 276-279

    • DOI

      10.1016/j.etap.2017.04.019

    • NAID

      120006715533

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed

URL: 

Published: 2016-04-21   Modified: 2019-03-29  

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