Combined effects of components of PM2.5 on early stage of biological and immune responses.

Research Project

Project/Area Number	16K19272
Research Category	Grant-in-Aid for Young Scientists (B)
Allocation Type	Multi-year Fund
Research Field	Hygiene and public health
Research Institution	Kyoto University
Principal Investigator	Honda Akiko 京都大学, 工学研究科, 助教 (20454324)
Project Period (FY)	2016-04-01 – 2018-03-31
Project Status	Completed (Fiscal Year 2017)
Budget Amount *help	¥4,030,000 (Direct Cost: ¥3,100,000、Indirect Cost: ¥930,000) Fiscal Year 2017: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000) Fiscal Year 2016: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Keywords	PM2.5 / アレルギー / 気管支喘息 / 複合影響 / PM2.5成分 / 環境 / アレルギー・ぜんそく
Outline of Final Research Achievements	We investigated combined effects of components of PM2.5 on respiratory and immune cells to elucidate the underlying mechanisms by which PM2.5 lead to the development and/or exacerbation of allergic diseases such as asthma. This study indicates components of PM2.5 can contribute to the development and/or exacerbation of asthma by disruption of respiratory and immune systems independently or synergistically.