| Project/Area Number |
16K19277
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Hygiene and public health
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| Research Institution | Juntendo University |
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Principal Investigator |
Muto Go 順天堂大学, 医学部, 非常勤講師 (10594971)
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| Project Period (FY) |
2016-04-01 – 2020-03-31
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| Project Status |
Completed (Fiscal Year 2019)
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| Budget Amount *help |
¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000)
Fiscal Year 2018: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000)
Fiscal Year 2017: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2016: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
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| Keywords | TRAF6 / 分子疫学 / 環境疫学 / Th2慢性炎症 / アレルギー / 腸内細菌叢 / Anisakis pegreffii / パラベ類 / 環境化学物質 / メタボロミクス / 制御性Ｔ細胞 / 慢性炎症 / 自然炎症 / Th2型炎症 / 疫学 / 衛生 / 社会医学 |
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| Outline of Final Research Achievements |
TRAF6 is one of essential molecules in inflammatory cascade of immune systems. We identified TRAF6 is essential not only in innate system but also in adaptive system especially in Th2 skewing inflammations such as several allergic diseases (Nat Med 2006, PLoS One 2013). Our findings suggested some environmental triggers such as toxic chemicals including triclosan and parabens might be associated with atopic dermatitis in children (Asia Pac Allergy 2019), which could be modulated through microbe environmental changes (Allergy 2019).
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| Academic Significance and Societal Importance of the Research Achievements |
アレルゲンで感作したマウスはtriclosan摂取による気管支喘息増悪が示され、その条件としてTLR２シグナル、triclosan摂取の両者が必要であると示唆された。またtriclosan摂取マウスの腸内細菌叢はclostridiaの割合がtriclosan濃度依存的に増えることが示唆された。ヒト小児フィールドの疫学調査から、既に市販品からの成分が除去されたtriclosanの尿中検出をみとめなかったが、同様の抗菌性防腐作用を持つmethyl, ethyl, butyl, and propyl parabenとアレルギー疾患の有意な関連を認めた。
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