Record linkage study using cancer registry data and DPC data: Toward the development of medical big data and the equity of cancer-related healthcare

• Project/Area Number: 16K19291
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Multi-year Fund
• Research Field: Medical and hospital managemen
• Research Institution: Osaka International Cancer Institute
• Principal Investigator: Morishima Toshitaka 地方独立行政法人大阪府立病院機構大阪国際がんセンター(研究所), その他部局等, がん対策センター政策情報部副部長 (10728893)
• Project Period (FY): 2016-04-01 – 2020-03-31
• Project Status: Completed (Fiscal Year 2019)
• Budget Amount: ¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000); Fiscal Year 2019: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000); Fiscal Year 2018: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000); Fiscal Year 2017: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000); Fiscal Year 2016: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
• Keywords: がん登録 / DPCデータ / リンケージ / リアルワールド / 均てん化 / 医療の質 / リスク調整 / ヘルスサービスリサーチ / リアルワールドデータ / ヘルササービスリサーチ / 希少がん / 緩和ケア / 医療・福祉 / 病院・医療管理学 / がん

Outline of Final Research Achievements

The following analyses were performed. 1) I explored the regional/institutional variations in practice patterns for cancer patients, 2) developed the methods of risk adjustment for calculating long-term survival rate, 3) created real-world evidence of optimal cancer treatments, particularly for patient populations who have scarce evidence from experimental clinical trials, 4) and revealed the social issues of cancer care (eg, cancer survivorship, palliative care, and networking of hospitals).

Academic Significance and Societal Importance of the Research Achievements

上述したような独創的な研究成果をあげることによって、がん登録データと診療情報データの連結解析の有用性を示した。また、データリンケージががん登録データを使う研究の可能性を広げられることを示した。本研究の成果はリンケージデータでなければ成し遂げられないものである。

Research Products

• [Int'l Joint Research] Rutgers University/University of Texas(米国)
• [Int'l Joint Research] University of Texas(米国)
• [Int'l Joint Research] London School of Hygiene & Tropical Med(United Kingdom)
• [Int'l Joint Research] London School of Hygiene & Tropical Med(United Kingdom)
• [Journal Article] Effect of adjuvant chemotherapy on survival benefit in stage III colon cancer patients stratified by age: a Japanese real-world cohort study (2020)
  • Author(s): Kawamura Hidetaka、Morishima Toshitaka、Sato Akira、Honda Michitaka、Miyashiro Isao
  • Journal Title: BMC Cancer Volume: 20 Issue: 1 Pages: 19-19
  • DOI: 10.1186/s12885-019-6508-1
  • Peer Reviewed / Open Access
• [Journal Article] Hospital volume and postoperative 5‐year survival for five different cancer sites: A population‐based study in Japan (2020)
  • Author(s): Okawa Sumiyo、Tabuchi Takahiro、Morishima Toshitaka、Koyama Shihoko、Taniyama Yukari、Miyashiro Isao
  • Journal Title: Cancer Science Volume: 111 Issue: 3 Pages: 985-993
  • DOI: 10.1111/cas.14309
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Oral cavity cancer incidence rates in Osaka, Japan between 2000 and 2014 (2020)
  • Author(s): Koyama Shihoko、Tabuchi Takahiro、Okawa Sumiyo、Morishima Toshitaka、Ishimoto Shunsuke、Ishibashi Miki、Miyashiro Isao
  • Journal Title: Oral Oncology Volume: 105 Pages: 104653-104653
  • DOI: 10.1016/j.oraloncology.2020.104653
  • Peer Reviewed
• [Journal Article] Hospital surgical volume and 3-year mortality in severe prognosis cancers: A population-based study using cancer registry data (2020)
  • Author(s): Taniyama Yukari、Tabuchi Takahiro、Ohno Yuko、Morishima Toshitaka、Okawa Sumiyo、Koyama Shihoko、Miyashiro Isao
  • Journal Title: Journal of Epidemiology Volume: - Issue: 1 Pages: 52-58
  • DOI: 10.2188/jea.je20190242
  • NAID: 130007965898
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] High incidence of head and neck cancers after endoscopic resection for esophageal cancer in younger patients (2020)
  • Author(s): Maekawa A, Ishihara R, Iwatsubo T, Nakagawa K, Ohmori M, Iwagami H, Matsuno K, Inoue S, Arao M, Nakahira H, Matsuura N, Schichijo S, Kanesaka T, Yamamoto S, Takeuchi Y, Higashino K, Uedo N, Fujii T, Morishima T, Miyashiro I
  • Journal Title: Journal of Gastroenterology Volume: 55 Issue: 4 Pages: 401-407
  • DOI: 10.1007/s00535-019-01653-y
  • Peer Reviewed / Open Access
• [Journal Article] がん患者における医療保険の種別・本人家族別にみた検診発見がん及び早期がんの割合 (2020)
  • Author(s): 森島敏隆, 佐藤亮, 中田佳世, 濱秀聡, 田淵貴大, 松本吉史, 小枝伸行, 島田裕子, 丸濱勉, 松木大作, 宮代勲, 大阪府がん診療連携協議会がん登録・情報提供部会
  • Journal Title: 厚生の指標 Volume: 67
  • Peer Reviewed
• [Journal Article] Impact of Comorbidities on Survival in Gastric, Colorectal, and Lung Cancer Patients (2019)
  • Author(s): Morishima T, Matsumoto Y, Koeda N, Shimada H, Maruhama T, Matsuki D, Nakata K, Ito Y, Tabuchi T, Miyashiro I
  • Journal Title: Journal of Epidemiology Volume: 29 Issue: 3 Pages: 110-115
  • DOI: 10.2188/jea.JE20170241
  • NAID: 130007607642
  • ISSN: 0917-5040, 1349-9092
  • Year and Date: 2019-03-05
  • Peer Reviewed / Open Access
• [Journal Article] Effects of laughter therapy on quality of life in patients with cancer: An open-label, randomized controlled trial (2019)
  • Author(s): Morishima Toshitaka、Miyashiro Isao、Inoue Norimitsu、Kitasaka Mitsuko、Akazawa Takashi、Higeno Akemi、Idota Atsushi、Sato Akira、Ohira Tetsuya、Sakon Masato、Matsuura Nariaki
  • Journal Title: PLOS ONE Volume: 14 Issue: 6 Pages: 0219065-0219065
  • DOI: 10.1371/journal.pone.0219065
  • Peer Reviewed / Open Access
• [Journal Article] Risk of subsequent primary cancers after carbon ion radiotherapy, photon radiotherapy, or surgery for localised prostate cancer: a propensity score-weighted, retrospective, cohort study (2019)
  • Author(s): Mohamad Osama、Tabuchi Takahiro、Nitta Yuki、Nomoto Akihiro、Sato Akira、Kasuya Goro、Makishima Hirokazu、Choy Hak、Yamada Shigeru、Morishima Toshitaka、Tsuji Hiroshi、Miyashiro Isao、Kamada Tadashi
  • Journal Title: The Lancet Oncology Volume: 20 Issue: 5 Pages: 674-685
  • DOI: 10.1016/s1470-2045(18)30931-8
  • Peer Reviewed / Int'l Joint Research
• [Journal Article] Epidemiological and clinical analyses of cervical cancer using data from the population-based Osaka cancer registry (2019)
  • Author(s): Yagi A, Ueda Y, Kakuda M, Tanaka Y, Ikeda S, Matsuzaki S, Kobayashi E, Morishima T, Miyashiro I, Fukui K, Ito Y, Nakayama T, Kimura T
  • Journal Title: Cancer Research Volume: 79 Issue: 6 Pages: 1252-1259
  • DOI: 10.1158/0008-5472.can-18-3109
  • Peer Reviewed / Open Access
• [Journal Article] Impact of age at diagnosis of head and neck cancer on incidence of metachronous cancer (2019)
  • Author(s): Iwatsubo T、Ishihara R、Morishima T、Maekawa A、Nakagawa K、Arao M、Ohmori M、Iwagami H、Matsuno K、Inoue S、Nakahira H、Matsuura N、Shichijo S、Kanesaka T、Yamamoto S、Takeuchi Y、Higashino K、Uedo N、Miyashiro I、Higuchi K、Fujii T
  • Journal Title: BMC Cancer Volume: 19 Issue: 1 Pages: 3-3
  • DOI: 10.1186/s12885-018-5231-7
  • Peer Reviewed / Open Access
• [Journal Article] Time trends in the incidence of esophageal adenocarcinoma, gastric adenocarcinoma, and superficial esophagogastric junction adenocarcinoma (2019)
  • Author(s): Matsuno K, Ishihara R, Ohmori M, Iwagami H, Shichijyo S, Maekawa A, Kanesaka T, Yamamoto S, Takeuchi Y, Higashino K, Uedo N, Matsunaga T, Morishima T, Miyashiro I
  • Journal Title: Journal of Gastroenterology Volume: 54 Issue: 9 Pages: 784-791
  • DOI: 10.1007/s00535-019-01577-7
  • Peer Reviewed
• [Journal Article] Increase in incidental detection of thyroid cancer in Osaka, Japan (2018)
  • Author(s): Toyoda Y, Tabuchi T, Nakata K, Morishima T, Nakayama T, Miyashiro I, Hojo S, Yoshioka S
  • Journal Title: Cancer Science Volume: 109 Issue: 7 Pages: 2310-2314
  • DOI: 10.1111/cas.13645
  • Peer Reviewed / Open Access
• [Journal Article] Impact of comorbidities on survival in gastric, colorectal, and lung cancer patients. (2018)
  • Author(s): Morishima T, Matsumoto Y, Koeda N, Shimada H, Maruhama T, Matsuki D, Nakata K, Ito Y, Tabuchi T, Miyashiro I.
  • Journal Title: Journal of Epidemiology Volume: 印刷中
  • NAID: 130007607642
  • Peer Reviewed
• [Journal Article] Sex differences in lung cancer survival: long-term trends using population-based cancer registry data in Osaka, Japan (2017)
  • Author(s): Kinoshita, F. L. Ito, Y. Morishima, T. Miyashiro, I. Nakayama, T.
  • Journal Title: Japanese journal of clinical oncology Volume: 9 Issue: 9 Pages: 863-869
  • DOI: 10.1093/jjco/hyx094
  • Peer Reviewed / Open Access
• [Journal Article] Association of interleukin 1 receptor-like 1 gene polymorphisms with eosinophilic phenotype in Japanese adults with asthma. (2017)
  • Author(s): Inoue H, Ito I, Niimi A, Matsumoto H, Oguma T, Tajiri T, Iwata T, Nagasaki T, Kanemitsu Y, Morishima T, Hirota T, Tamari M, Wenzel SE, Mishima M.
  • Journal Title: Respiratory Investigation Volume: 55 Issue: 6 Pages: 338-347
  • DOI: 10.1016/j.resinv.2017.08.006
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Presentation] がん患者における医療保険の種別・本人家族別にみた検診発見がん及び早期がんの割合 (2020)
  • Author(s): 森島敏隆, 佐藤亮, 中田佳世, 濱秀聡, 田淵貴大, 宮代勲
  • Organizer: 第30回日本疫学会学術総会
• [Presentation] がん患者の併存疾患と生命予後 (2019)
  • Author(s): 森島敏隆
  • Organizer: 第42回日本がん疫学・分子疫学研究会総会
  • Invited
• [Presentation] がん登録と診療情報データとのリンケージデータを用いた臨床疫学研究 (2019)
  • Author(s): 森島敏隆
  • Organizer: 2019年度日本計量生物学会年会
  • Invited
• [Presentation] がんの初回治療を行う病院は患者死亡の何日前まで自院で診療しているのか―DPC データと大阪府がん登録データをリンケージした多施設研究― (2019)
  • Author(s): 森島敏隆, 佐藤亮, 中田佳世, 松本吉史, 小枝伸行, 島田裕子, 丸濱勉, 松木大作, 宮代勲
  • Organizer: 第37回医療情報学連合大会
• [Presentation] がんの初回治療を行う病院は患者死亡の何日前まで自院で診療しているのか (2019)
  • Author(s): 森島敏隆，佐藤亮，中田佳世，宮代勲
  • Organizer: 第78回日本公衆衛生学会総会
• [Presentation] 病理診断において自施設実施の検査結果を診断根拠としている割合はどれだけあるか？ (2019)
  • Author(s): 森島敏隆, 佐藤亮, 中田佳世, 濱秀聡, 久馬麻希, 松本充恵, 石田理恵, 宮代勲
  • Organizer: 日本がん登録協議会第28回学術集会
• [Presentation] Validity of claims-based definitions for rheumatoid arthritis, selected cancers and infectious diseases in Japan: Results from Validate-J Study (2019)
  • Author(s): Luise C, Chen H, Nonnenmacher E, Sugiyama N, Hase R, Kinjo M, Suzuki D, Katayama K, Higuchi T, Jinno S, Tanaka Y, Morishima T, Setoguchi S
  • Organizer: 35th International Conference on Pharmacoepidemiology and Therapeutic Risk Management (ICPE)
  • Int'l Joint Research
• [Presentation] Validity of claims-based definitions for rheumatoid arthritis, selected cancers and infectious diseases in Japan: Results from Validate-J Study (2019)
  • Author(s): Sugiyama N, Luise C, Chen H, Nonnenmacher E, Hase R, Kinjo M, Suzuki D, Katayama K, Higuchi T, Jinno S, Tanaka Y, Morishima T, Setoguchi S
  • Organizer: 12th Asian Conference on Pharmacoepidemiology
  • Int'l Joint Research
• [Presentation] がん患者における高齢者機能評価と生命予後の関連―大阪府がん登録とDPCデータのリンケージで得た知見― (2019)
  • Author(s): 森島敏隆，佐藤亮，中田佳世，宮代勲
  • Organizer: 第29回日本疫学会学術総会
• [Presentation] がん診断後の就労状況を医療保険で観察―大阪府がん登録と多施設DPCデータからの知見 (2018)
  • Author(s): 森島敏隆，佐藤亮，中田佳世，松本吉史，小枝伸行，島田裕子，丸濱勉，松木大作，宮代勲
  • Organizer: 第56回日本癌治療学会学術集会
• [Presentation] 笑いとがん患者のQOL―継続的介入の効果を示した無作為化比較試験― (2018)
  • Author(s): 森島敏隆，北坂美津子，井上徳光，赤澤隆，髭野明美，井戸田篤，佐藤亮，宮代勲，左近賢人
  • Organizer: 第56回日本癌治療学会学術集会
• [Presentation] 高齢者進行非小細胞肺癌のプラチナ併用の有無と1年生存―多施設データによる因果推論 (2018)
  • Author(s): 森島敏隆，佐藤亮，中田佳世，宮代勲
  • Organizer: 第56回日本癌治療学会学術集会
• [Presentation] Platinum-based chemotherapy for lung cancer in the elderly: A record-linkage study (2018)
  • Author(s): 森島敏隆，佐藤亮，中田佳世，宮代勲
  • Organizer: 日本臨床疫学会第2回年次学術大会
• [Presentation] がん患者における高齢者機能評価と生命予後―DPCデータと大阪府がん登録データをリンケージした多施設研究― (2018)
  • Author(s): 森島敏隆，佐藤亮, 中田佳世, 松本吉史, 小枝伸行, 島田裕子, 丸濱勉, 松木大作, 宮代勲
  • Organizer: 第22回日本医療情報学会春季学術大会
• [Presentation] がん患者における高齢者機能評価と生命予後―大阪府がん登録データとDPCデータのリンケージで得た知見― (2018)
  • Author(s): 森島敏隆, 佐藤亮, 中田佳世, 久馬麻希, 千葉真実, 松本充恵, 石田理恵, 田淵貴大, 宮代勲
  • Organizer: 日本がん登録協議会第27回学術集会
• [Presentation] 高齢者では肺癌術後の長期予後における過剰死亡リスクが高くなるのか. (2017)
  • Author(s): 宮代勲, 伊藤ゆり，森島敏隆，中田佳世，田淵貴大，岡見次郎，東山聖彦，松浦成昭.
  • Organizer: 第27回日本疫学会学術総会
  • Place of Presentation: 甲府
  • Year and Date: 2017-01-25
• [Presentation] DPCデータと大阪府の地域がん登録データをリンケージした多施設研究―がん診断時のDPCデータでがん生命予後を予測できるか―. (2017)
  • Author(s): 森島敏隆, 松本吉史, 小枝伸行, 島田裕子, 丸濱勉, 松木大作, 中田佳世, 宮代勲.
  • Organizer: 第37回医療情報学連合大会
• [Presentation] がん診断後の医療保険の切り替えは就労状況の把握のための代理指標となるか? (2017)
  • Author(s): 森島敏隆，松本吉史，中田佳世，田淵貴大，中山富雄，宮代勲.
  • Organizer: 第55回日本癌治療学会学術集会
• [Presentation] 肉腫の治療実態と治療成績:地域がん登録とDPCデータの連結による多施設での知見. (2017)
  • Author(s): 森島敏隆，松本吉史，中田佳世，田淵貴大，中山富雄，宮代勲.
  • Organizer: 第55回日本癌治療学会学術集会
• [Presentation] 併存症はがん診断後の生存期間に影響するのか？―地域がん登録とＤＰＣデータの連結で得た知見―. (2017)
  • Author(s): 森島敏隆, 松本吉史, 松本充恵, 石田理恵, 中田佳世, 宮代勲.
  • Organizer: 日本がん登録協議会第26回学術集会
• [Presentation] 地域がん登録データを活用した自府県のがん罹患・死亡の位置づけの評価. (2016)
  • Author(s): 伊藤ゆり, 福井敬祐, 森島敏隆, 中田佳世, 田淵貴大, 宮代勲, 中山富雄, 里村征紀, 田中修.
  • Organizer: 第75回日本公衆衛生学会総会
  • Place of Presentation: 大阪
  • Year and Date: 2016-10-26
  • Invited
• [Presentation] 協働で取り組むがん対策－がん対策ツールとしてのがん登録. (2016)
  • Author(s): 宮代勲, 伊藤ゆり，田淵貴大，中山富雄，福井敬祐，中田佳世，森島敏隆，里村征紀，田中修.
  • Organizer: 第75回日本公衆衛生学会総会
  • Place of Presentation: 大阪
  • Year and Date: 2016-10-26
  • Invited
• [Presentation] Transitions between hospitals during the course from diagnosis of cancer until death: a population-based study using cancer registry data. (2016)
  • Author(s): Morishima T, Nakata K, Miyashiro I, Matsuura N.
  • Organizer: The 33rd Conference of International Society for Quality in Health Care (ISQua)
  • Place of Presentation: 東京
  • Year and Date: 2016-10-16
  • Int'l Joint Research
• [Presentation] 高齢者では膵癌術後長期予後の過剰死亡リスクが高くなるのか (2016)
  • Author(s): 宮代勲, 伊藤ゆり，中田佳世，森島敏隆，田淵貴大，中山富雄，秋田裕史，高橋秀典，松浦成昭.
  • Organizer: 第75回日本癌学会学術総会
  • Place of Presentation: 横浜
  • Year and Date: 2016-10-06
• [Presentation] Trends in survival of childhood cancer in Osaka, Japan, 1975-2009. (2016)
  • Author(s): Nakata K, Miyashiro I, Morishima T, Ito Y, Inoue M, Hara J, Kawa K, Matsuura N.
  • Organizer: Scientific Meeting and General Assembly of European Network of Cancer Registries
  • Place of Presentation: Bevano, Italy
  • Year and Date: 2016-10-05
  • Int'l Joint Research
• [Presentation] 上部消化管がんフォローアップ5 年の妥当性―長期予後保有がん登録データベースの利活用例(J-CANSIS 研究) (2016)
  • Author(s): 宮代勲, 伊藤ゆり，中田佳世，森島敏隆，服部昌和，松浦成昭.
  • Organizer: 第71回日本消化器外科学会総会
  • Place of Presentation: 徳島
  • Year and Date: 2016-07-14