Evaluation of cognitive function of elderly persons who suffered fatal accidents based on neurodegenerative pathology in the olfactory system
| Project/Area Number |
16K19297
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Legal medicine
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| Research Institution | Kochi University |
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Principal Investigator |
FURUMIYA Junichi 高知大学, 教育研究部医療学系連携医学部門, 教授 (60363280)
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| Project Period (FY) |
2016-04-01 – 2019-03-31
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| Project Status |
Completed (Fiscal Year 2018)
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| Budget Amount *help |
¥2,860,000 (Direct Cost: ¥2,200,000、Indirect Cost: ¥660,000)
Fiscal Year 2018: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2017: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2016: ¥780,000 (Direct Cost: ¥600,000、Indirect Cost: ¥180,000)
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| Keywords | 認知症高齢者 / 嗅覚 / 法医学 / 不慮の死亡事故 / 神経病理学 |
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| Outline of Final Research Achievements |
We examined neurodegeneration in the olfactory system of elderly persons by evaluating Gallyas-Braak score and the expression of tau- and alpha-synuclein immunoreactivity in forensic autopsy cases. As a result, those who had dementia showed significantly higher tau- and Gallyas-Braak scores in the anterior olfactory nucleus, peripheral olfactory bulb and the entorhinal cortex. Our results suggested that the neuropathological examination in the olfactory system was useful for evaluating cognitive function of elderly persons who suffered fatal accidents.
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| Academic Significance and Societal Importance of the Research Achievements |
高齢者の不慮の死亡事故における日々の法医鑑定業務では、生前の認知機能障害程度やそれが死亡事故に及ぼす影響について問題となることがある。しかし、生前の認知機能に問題がないという高齢者の不慮の死亡事故の場合、死後における神経病理学的認知機能の評価方法やその法医学的意義について、これまでほとんど検証されてこなかった。本研究では、嗅覚系の神経病理学的検査手法を用いた高齢者の不慮の死亡事故における認知機能評価の有用性について検討することから社会的に意義深いと考える。
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Report
(4 results)
Research Products
(1 results)
