Molecular mechanism of sarcopenia in cancer patients
Project/Area Number |
16K19310
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Research Category |
Grant-in-Aid for Young Scientists (B)
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Allocation Type | Multi-year Fund |
Research Field |
General internal medicine(including psychosomatic medicine)
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Research Institution | Gifu University |
Principal Investigator |
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Research Collaborator |
NINOMIYA SORANOBU
|
Project Period (FY) |
2016-04-01 – 2019-03-31
|
Project Status |
Completed (Fiscal Year 2018)
|
Budget Amount *help |
¥4,030,000 (Direct Cost: ¥3,100,000、Indirect Cost: ¥930,000)
Fiscal Year 2018: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2017: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2016: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
|
Keywords | サルコペニア / トリプトファン / 癌 |
Outline of Final Research Achievements |
Our data show for the first time that tryptophan(Trp) deficiency underlies skeletal muscle atrophy in cancer-related sarcopenia, and we have established a direct link between cancer-related sarcopenia and Trp. Given that evaluations of cancer-related sarcopenia are useful for predicting the prognoses of some cancers and decision-making in relation to treatment strategies, we postulate that the serum Trp level might become a valuable biomarker of sarcopenia development and progression. The results from the present study also indicate that targeting the Trp and kynurenine pathway that is mediated by IDO, might be a promising tactic for preventing or treating sarcopenia in patients with cancer.
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Academic Significance and Societal Importance of the Research Achievements |
本研究による成果により、これまで十分明らかになっていなかった癌患者におけるサルコペニア発症機序の一因を示した。癌患者では発症早期よりアミノ酸バランス異常が起きており、特にトリプトファンの低下が報告されている。このトリプトファン欠乏が骨格筋萎縮を引き起こしていることがわかり、今後サルコペニア発症の予測因子、発症予防、さらには治療ターゲットとして臨床応用されることが期待される。
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Report
(4 results)
Research Products
(5 results)
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[Journal Article] Serum concentrations of l-kynurenine predict clinical outcomes of patients with peripheral T-cell lymphoma, not otherwise specified.2016
Author(s)
Shibata Y, Hara T, Matsumoto T, Nakamura N, Nakamura H, Ninomiya S, Kitagawa J, Goto N, Nannya Y, Ito H, Kito Y, Miyazaki T, Takeuchi T, Saito K, Seishima M, Takami T, Moriwaki H, Shimizu M, Tsurumi H.
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Journal Title
Hematological Oncology
Volume: -
Issue: 4
Pages: 637-644
DOI
Related Report
Peer Reviewed / Open Access
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[Journal Article] Garenoxacin Prophylaxis for Febrile Neutropenia after Chemotherapy in Hematological Malignancies.2016
Author(s)
Nakamura, N. , Hara, T. , Ninomiya, S. , Shibata, Y. , Matsumoto, T. , Nakamura, H. , Kitagawa, J. , Nannya, Y. , Shimizu, M. , Murakami, N. and Tsurumi, H.
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Journal Title
Open Journal of Internal Medicine
Volume: 6
Issue: 04
Pages: 128-138
DOI
Related Report
Peer Reviewed
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