Antiemetic therapy with chronotherapy and phototherapy for patients with cancer chemotherapy

• Project/Area Number: 16K19315
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Multi-year Fund
• Research Field: General internal medicine(including psychosomatic medicine)
• Research Institution: Kagawa University
• Principal Investigator: Uemura Makiko 香川大学, 医学部, 助教 (00710188)
• Project Period (FY): 2016-04-01 – 2020-03-31
• Project Status: Completed (Fiscal Year 2019)
• Budget Amount: ¥2,730,000 (Direct Cost: ¥2,100,000、Indirect Cost: ¥630,000); Fiscal Year 2018: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000); Fiscal Year 2017: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000); Fiscal Year 2016: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
• Keywords: chronotherapy / phototherapy / 光療法 / がん化学療法 / 制吐剤 / 悪心嘔吐 / 時計遺伝子 / 概日リズム / 菌血症 / 熱型 / 支持療法 / 制吐療法

Outline of Final Research Achievements

A comprehensive analysis of the cases with bacteremia in cancer chemotherapy patients revealed mortality due to bacteremia in 16.2% (17/105 cases), and those cases died of bacteremia within 30 days. The distribution of the onset time of bacteremia did not significantly differed in survival depending on the time of day. The survival rate of the night-onset group tended to be lower than that of the daytime-onset group.

Academic Significance and Societal Importance of the Research Achievements

がん化学療法患者における菌血症の治療成績が発症時間帯で異なることが示され、宿主の睡眠状態や日内変動がそれを左右することが示唆された。今後のがん化学療法支持療法の介入タイミングに参考となる。

Research Products

• [Journal Article] Fatal fulminant hemolysis-associated pulmonary embolism in mixed-type autoimmune hemolytic anemia (2020)
  • Author(s): Imataki Osamu、Iseki Kikuo、Uchida Shumpei、Uemura Makiko、Kadowaki Norimitsu
  • Journal Title: Medicine Volume: 99 Issue: 6 Pages: e18984-e18984
  • DOI: 10.1097/md.0000000000018984
  • Peer Reviewed / Open Access
• [Journal Article] Nonclonal chromosomal alterations and poor survival in cytopenic patients without hematological malignancies (2019)
  • Author(s): Imataki Osamu、Kubo Hiroyuki、Takeuchi Akihiro、Uemura Makiko、Kadowaki Norimitsu
  • Journal Title: Molecular Cytogenetics Volume: 12 Issue: 1 Pages: 46-46
  • DOI: 10.1186/s13039-019-0458-9
  • Peer Reviewed / Open Access
• [Journal Article] Effect of ultrasound-guided central venous catheter insertion on the incidence of catheter-related bloodstream infections and mechanical complications (2019)
  • Author(s): Imataki Osamu、Shimatani Mami、Ohue Yukiko、Uemura Makiko
  • Journal Title: BMC Infectious Diseases Volume: 19 Issue: 1 Pages: 857-857
  • DOI: 10.1186/s12879-019-4487-0
  • Peer Reviewed / Open Access
• [Journal Article] Diagnostic Value of Flow Cytometry Standardized Using the European LeukemiaNet for Myelodysplastic Syndrome (2019)
  • Author(s): Takeuchi Akihiro、Imataki Osamu、Kubo Hiroyuki、Kondo Akihiro、Seo Kayoko、Uemura Makiko、Yamaoka Genji、Murao Koji、Takeuchi Akihiro
  • Journal Title: Acta Haematologica Volume: 143 Issue: 2 Pages: 140-145
  • DOI: 10.1159/000501147
  • Peer Reviewed
• [Journal Article] c-D-index is a risk factor for prolonged febrile neutropenia during chemotherapy in patients with acute myeloid leukemia. (2019)
  • Author(s): Kubo Hiroyuki, Imataki Osama, Kubo Yukiko, Uemura M, Kadowaki N.
  • Journal Title: nt J Clin Oncol Volume: 24 Issue: 5 Pages: 590-595
  • DOI: 10.1007/s10147-018-01384-9
  • Peer Reviewed
• [Journal Article] Bendamustine and G-CSF support (2018)
  • Author(s): Imataki Osamu、Uchida Shumpei、Yokokura Shigeyuki、Uemura Makiko、Kadowaki Norimitsu
  • Journal Title: Supportive Care in Cancer Volume: 27 Issue: 5 Pages: 1581-1582
  • DOI: 10.1007/s00520-018-4118-0
  • Peer Reviewed
• [Journal Article] Voriconazole concentration is inversely correlated with corticosteroid usage in immunocompromised patients (2018)
  • Author(s): Imataki Osamu、Yamaguchi Kazunori、Uemura Makiko、Fukuoka Noriyasu
  • Journal Title: Transplant Infectious Disease Volume: 20 Issue: 4
  • DOI: 10.1111/tid.12886
  • Peer Reviewed
• [Journal Article] Pure erythroid leukemia in a polymyositis patient treated with azathioprine (2018)
  • Author(s): Imataki Osamu、Takeuchi Akihiro、Uchida Shumpei、Yokokura Shigeyuki、Uemura Makiko、Kadowaki Norimitsu
  • Journal Title: Rare Tumors Volume: 10
  • DOI: 10.1177/2036361318773847
  • Peer Reviewed / Open Access
• [Journal Article] B-chronic lymphocytic leukemia showed triple transformation, to diffuse large B cell, CD20-negative, and T-cell neoplasm during ofatumumab treatment: a case report (2018)
  • Author(s): Imataki Osamu、Uemura Makiko
  • Journal Title: BMC Clinical Pathology Volume: 18 Issue: 1
  • DOI: 10.1186/s12907-018-0072-5
  • Peer Reviewed / Open Access
• [Journal Article] Asymptomatic hepatosplenomegaly in chronic myeloid leukemia. (2018)
  • Author(s): Imataki Osamu、Uemura Makiko
  • Journal Title: Oxf Med Case Reports Volume: 10 Pages: 48-48
• [Journal Article] Central Nervous System Peripheral T Cell Lymphoma Manifesting as Lymphomatosis Cerebri That Was Misdiagnosed as Neuro-Beh?et’s Disease: A Case Report (2018)
  • Author(s): Imataki Osamu、Uchida Shumpei、Yokokura Shigeyuki、Uemura Makiko、Kadowaki Norimitsu
  • Journal Title: Case Reports in Oncology Volume: 11 Issue: 3 Pages: 806-813
  • DOI: 10.1159/000495033
  • Peer Reviewed / Open Access
• [Journal Article] Anemia and hypogammaglobulinemia caused by Ménétrier's disease. (2017)
  • Author(s): Imataki O, Uchida S, Yokokura S, Uemura M, Kadowaki N.
  • Journal Title: Int J Hematol. Volume: 107 Issue: 1 Pages: 3-4
  • DOI: 10.1007/s12185-017-2349-3
  • Peer Reviewed
• [Journal Article] Enteral Malakoplakia Prior to Helicobacter cinaedi Bacteremia. (2017)
  • Author(s): Imataki O, Kawashima K, Uchida S, Yokokura S, Uemura M, Kadowaki N.
  • Journal Title: Am J Gastroenterol Volume: 112 Issue: 1 Pages: 187-188
  • DOI: 10.1038/ajg.2016.514
  • Peer Reviewed
• [Journal Article] Nutritional risk in allogeneic stem cell transplantation: rationale for a tailored nutritional pathway. (2017)
  • Author(s): Aoyama T, Imataki O, Mori K, Yoshitsugu K, Fukaya M, Okamura I, Enami T, Tatara R, Ikeda T.
  • Journal Title: Ann Hematol. Volume: 96 Issue: 4 Pages: 617-625
  • DOI: 10.1007/s00277-016-2910-9
  • Peer Reviewed
• [Journal Article] Low-dose anti-thymocyte globulin reduce severe acute and chronic graft-versus-host disease after allogeneic stem cell transplantation (2017)
  • Author(s): Imataki O, Matsumoto K, Uemura M.
  • Journal Title: J Cancer Res Clin Oncol Volume: 143 Issue: 4 Pages: 709
  • DOI: 10.1007/s00432-016-2329-7
  • Peer Reviewed
• [Journal Article] Fatal Rhabdomyolysis Caused by <i>Morganella morganii</i> in a Patient with Multiple Myeloma (2017)
  • Author(s): Imataki O, Uemura M.
  • Journal Title: Internal Medicine Volume: 56 Issue: 3 Pages: 369-371
  • DOI: 10.2169/internalmedicine.56.7252
  • NAID: 130005310321
  • ISSN: 0918-2918, 1349-7235
  • Peer Reviewed
• [Journal Article] Bladder Rupture After Chronic Hemorrhagic Cystitis in a Stem Cell Transplantation Recipient. (2017)
  • Author(s): Imataki O, Uchida S, Kushida Y, Uemura M.
  • Journal Title: Transplantation Volume: 101 Issue: 8 Pages: e280-e281
  • DOI: 10.1097/tp.0000000000001810
  • Peer Reviewed
• [Journal Article] Acquired Inhibitors to Multiple Coagulation Factors (V, IX, and XII) Identified in a Unique Patient with Hepatocellular Carcinoma (2017)
  • Author(s): Imataki O, Arai T, Uemura M.
  • Journal Title: Internal Medicine Volume: 56 Issue: 10 Pages: 1203-1206
  • DOI: 10.2169/internalmedicine.56.7845
  • NAID: 130006858075
  • ISSN: 0918-2918, 1349-7235
  • Peer Reviewed
• [Journal Article] Methionine PET Might Be Reliable for the Detection of Low M-Protein-Producing Myelomas. (2017)
  • Author(s): Imataki O, Uchida S, Yokokura S, Uemura M, Kadowaki N.
  • Journal Title: Clin Nucl Med. Volume: 42 Issue: 11 Pages: e469-e471
  • DOI: 10.1097/rlu.0000000000001821
  • Peer Reviewed
• [Journal Article] Complete mimicry: a case of alveolar rhabdomyosarcoma masquerading as acute leukemia. (2017)
  • Author(s): Imataki O, Uemura M, Uchida S, Yokokura S, Takeuchi A, Ishikawa R, Kondo A, Seo K, Kadowaki N.
  • Journal Title: Diagn Pathol Volume: 12 Issue: 1 Pages: 77-77
  • DOI: 10.1186/s13000-017-0667-7
  • Peer Reviewed
• [Journal Article] Strain-specific transmission in an outbreak of ESBL-producing Enterobacteriaceae in the hemato-oncology care unit: a cohort study. (2016)
  • Author(s): Uemura M, Imataki O, Uchida S, Nakayama-Imaohji H, Ohue Y, Matsuka H, Mori H, Dobashi H, Kuwahara T, Kadowaki N.
  • Journal Title: BMC Infect Dis Volume: 17 Issue: 1 Pages: 26-26
  • DOI: 10.1186/s12879-016-2144-4
  • Peer Reviewed / Open Access
• [Journal Article] Tanaka S, Imataki O, Kitaoka A, Fujioka S, Hanabusa E, Ohbayashi Y, Uemura M, Arima N, Yamamoto T. (2016)
  • Author(s): Clinical impact of sarcopenia and relevance of nutritional intake in patients before and after allogeneic hematopoietic stem cell transplantation.
  • Journal Title: J Cancer Res Clin Oncol Volume: 143 Issue: 6 Pages: 2336-2338
  • DOI: 10.1007/s00432-016-2336-8
  • Peer Reviewed
• [Journal Article] Neurotropic infiltration and neuropathy of multifocal lymphoma. (2016)
  • Author(s): Imataki O, Kida J, Yokohira M, Uemura M.
  • Journal Title: Support Care Cancer Volume: 24 Issue: 5 Pages: 1939-1940
  • DOI: 10.1007/s00520-016-3098-1
  • Peer Reviewed
• [Journal Article] Antilymphocyte Globulin for Chronic Graft-versus-Host Disease. (2016)
  • Author(s): Imataki O, Uemura M, Kadowaki N.
  • Journal Title: N Engl J Med Volume: 374 Issue: 19 Pages: 1894-1894
  • DOI: 10.1056/nejmc1601364
  • Peer Reviewed
• [Journal Article] Perforation in an intestinal malignant lymphoma case. (2016)
  • Author(s): Imataki O, Shiroshita K, Uchida S, Kida J, Akamoto S, Uemura M.
  • Journal Title: BMC Res Notes Volume: 9 Issue: 1 Pages: 308-308
  • DOI: 10.1186/s13104-016-2111-6
  • Peer Reviewed / Open Access
• [Journal Article] The Leading Seafood Cuisine of Anisakidosis in Japan. (2016)
  • Author(s): Imataki O, Bandoh S, Kawakami K, Uemura M.
  • Journal Title: Clin Infect Dis Volume: 62 Issue: 12 Pages: 1612-1613
  • DOI: 10.1093/cid/ciw196
  • Peer Reviewed
• [Journal Article] Fatal acute respiratory distress syndrome after stem cell infusion. (2016)
  • Author(s): Imataki O, Ura K, Uemura M.
  • Journal Title: Transfus Med. Volume: 26 Issue: 5 Pages: 387-389
  • DOI: 10.1111/tme.12336
  • Peer Reviewed
• [Journal Article] Chromosomal abnormality of acute promyelocytic leukemia other than PML-RARA: a case report of acute promyelocytic leukemia with del(5q). (2016)
  • Author(s): Imataki O, Uemura M.
  • Journal Title: BMC Clin Pathol Volume: 16 Pages: 16-16
  • Peer Reviewed
• [Journal Article] Charlson comorbidity index predicts poor outcome in CML patients treated with tyrosine kinase inhibitor. (2016)
  • Author(s): Uemura M, Imataki O, Kawachi Y, Kawakami K, Hoshijima Y, Matsuoka A, Kadowaki N.
  • Journal Title: Int J Hematol Volume: 104 Pages: 621-627
  • Peer Reviewed
• [Journal Article] Bone Marrow and Peripheral Blood: Which Is Safe? (2016)
  • Author(s): Imataki O, Uchida S, Yokokura S, Uemura M, Matsushita K, Kadowaki N.
  • Journal Title: Biol Blood Marrow Transplant Volume: 22 Issue: 12 Pages: 283-2284
  • DOI: 10.1016/j.bbmt.2016.09.015
  • Peer Reviewed
• [Journal Article] Chryseobacterium indologenes, a possible emergent organism resistant to carbapenem antimicrobials after stem cell transplantation. (2016)
  • Author(s): Imataki O, Uemura M.
  • Journal Title: Clin Case Rep Volume: 5 Issue: 1 Pages: 22-25
  • DOI: 10.1002/ccr3.753
  • Peer Reviewed / Acknowledgement Compliant
• [Journal Article] Paradoxical thrombosis in idiopathic thrombocytopenic purpura. (2016)
  • Author(s): Imataki O, Uchida S, Yokokura S, Uemura M, Kadowaki N.
  • Journal Title: Int J Hematol Volume: 105 Issue: 2 Pages: 111-112
  • DOI: 10.1007/s12185-016-2117-9
  • Peer Reviewed