| Budget Amount *help |
¥4,030,000 (Direct Cost: ¥3,100,000、Indirect Cost: ¥930,000)
Fiscal Year 2018: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2017: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2016: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
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| Outline of Final Research Achievements |
The biological significances of microRNA functional impairment during chronic inflammation was determined. When Dicer protein is decreased at about half level, it resulted in the higher possibilities of carcinogenesis. To discover the underlying molecular mechanisms, tetracyclin-regulated Dicer expressing cells were established, and using these cells it was found that CEB/P pathway is crucial in the inflammatory-tumorigenesis.ROCK inhibitor reverses these effects. Thus, ROCK inhibitor may be useful for the prevention of inflammation-associated tumorigenesis.
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