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Elucidation of the pathological condition of non-alcoholic fatty liver disease regarding retinoid receptor signaling

Research Project

Project/Area Number 16K19336
Research Category

Grant-in-Aid for Young Scientists (B)

Allocation TypeMulti-year Fund
Research Field Gastroenterology
Research InstitutionGifu University

Principal Investigator

Shirakmai Yohei  岐阜大学, 大学院医学系研究科, 助教 (50632816)

Project Period (FY) 2016-04-01 – 2018-03-31
Project Status Completed (Fiscal Year 2017)
Budget Amount *help
¥3,120,000 (Direct Cost: ¥2,400,000、Indirect Cost: ¥720,000)
Fiscal Year 2017: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2016: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Keywords非アルコール性脂肪性肝炎 / レチノイド / 糖尿病 / 脂肪肝 / NAFLD / 耐糖能 / 肥満 / 内科 / 脂質 / シグナル伝達
Outline of Final Research Achievements

Retinoid receptor signaling is focused to elucidate the pathological condition of non-alcoholic fatty liver disease (NAFLD). Transgenic mice, in which retinoic acid receptor (RAR) or retinoid X receptor (RXR) is dominant-negatively inhibited, were generated and the phenotypes were investigated. Steatohepatitis and glucose intolerance were exacerbated in RXR-transgenic mice fed high-fat diet. The signaling of RXR is thought to play important roles in development and progression of NAFLD and glucose metabolism.

Report

(3 results)
  • 2017 Annual Research Report   Final Research Report ( PDF )
  • 2016 Research-status Report
  • Research Products

    (28 results)

All 2018 2017 2016

All Journal Article (9 results) (of which Peer Reviewed: 9 results,  Open Access: 5 results) Presentation (19 results) (of which Int'l Joint Research: 4 results)

  • [Journal Article] Non-alcoholic steatohepatitis-related liver tumorigenesis is suppressed in mice lacking hepatic retinoid storage2017

    • Author(s)
      Ideta, T. Shirakami, Y. Ohnishi, M. Maruta, A. Obara, K. Miyazaki, T. Kochi, T. Sakai, H. Tomita, H. Tanaka, T. Blaner, W. S. Shimizu, M.
    • Journal Title

      Oncotarget

      Volume: 8 Issue: 41 Pages: 70695-70706

    • DOI

      10.18632/oncotarget.19978

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Preventive effects of the sodium glucose cotransporter 2 inhibitor tofogliflozin on diethylnitrosamine-induced liver tumorigenesis in obese and diabetic mice.2017

    • Author(s)
      Obara K, Shirakami Y, Maruta A, Ideta T, Miyazaki T, Kochi T, Sakai H, Tanaka T, Seishima M, Shimizu M.
    • Journal Title

      Oncotarget

      Volume: 8 Issue: 35 Pages: 58353-58363

    • DOI

      10.18632/oncotarget.16874

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Prevention of Colorectal Cancer by Targeting Obesity-Related Disorders and Inflammation2017

    • Author(s)
      Shirakami Yohei、Ohnishi Masaya、Sakai Hiroyasu、Tanaka Takuji、Shimizu Masahito
    • Journal Title

      Int J Mol Sci.

      Volume: 18 Issue: 5 Pages: 908-908

    • DOI

      10.3390/ijms18050908

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Preventative Effects of Pentoxifylline on the Development of Colonic Premalignant Lesions in Obese and Diabetic Mice2017

    • Author(s)
      Fukuta K, Shirakami Y, Maruta A, Obara K, Iritani S, Nakamura N, Kochi T, Kubota M, Sakai H, Tanaka T, Shimizu M
    • Journal Title

      Int J Mol Sci

      Volume: 18(2) Issue: 2 Pages: 413-413

    • DOI

      10.3390/ijms18020413

    • Related Report
      2016 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Catechins and Its Role in Chronic Diseases.2016

    • Author(s)
      Shirakami Y, Sakai H, Kochi T, Seishima M, Shimizu M.
    • Journal Title

      Adv Exp Med Biol.

      Volume: 929 Pages: 67-90

    • Related Report
      2016 Research-status Report
    • Peer Reviewed
  • [Journal Article] Cimetidine and Clobenpropit Attenuate Inflammation-Associated Colorectal Carcinogenesis in Male ICR Mice2016

    • Author(s)
      Tanaka T, Kochi T, Shirakami Y, Mori T, Kurata A, Watanabe N, Moriwaki H, Shimizu M
    • Journal Title

      Cancers

      Volume: 8 Issue: 2 Pages: 25-25

    • DOI

      10.3390/cancers8020025

    • Related Report
      2016 Research-status Report
    • Peer Reviewed
  • [Journal Article] Sodium alginate prevents progression of non-alcoholic steatohepatitis and liver carcinogenesis in obese and diabetic mice.2016

    • Author(s)
      Miyazaki T, Shirakami Y, Kubota M, Ideta T, Kochi T, Sakai H, Tanaka T, Moriwaki H, Shimizu M.
    • Journal Title

      Oncotarget.

      Volume: 7 Pages: 10448-10458

    • Related Report
      2016 Research-status Report
    • Peer Reviewed
  • [Journal Article] Chemoprevention of obesity-related liver carcinogenesis by using pharmaceutical and nutraceutical agents.2016

    • Author(s)
      Sakai H, Shirakami Y, Shimizu M.
    • Journal Title

      World J Gastroenterol

      Volume: 22(1) Issue: 1 Pages: 394-406

    • DOI

      10.3748/wjg.v22.i1.394

    • Related Report
      2016 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Metabolome Analyses Uncovered a Novel Inhibitory Effect of Acyclic Retinoid on Aberrant Lipogenesis in a Mouse Diethylnitrosamine-Induced Hepatic Tumorigenesis Model.2016

    • Author(s)
      Qin XY, Tatsukawa H, Hitomi K, Shirakami Y, Ishibashi N, Shimizu M, Moriwaki H, Kojima S.
    • Journal Title

      Cancer Prev Res

      Volume: 9 Pages: 205-214

    • Related Report
      2016 Research-status Report
    • Peer Reviewed
  • [Presentation] The roles of acyclic retinoid in blocking hepatocellular carcinoma.2018

    • Author(s)
      Shirakami Y
    • Organizer
      JSPS拠点形成プログラムシンポジウム「難治疾患に対する分子標的薬創製のための国際共同研究拠点の構築」
    • Related Report
      2017 Annual Research Report
  • [Presentation] 肥満に関連した肝疾患に対する糖尿病治療薬の作用2017

    • Author(s)
      白上洋平、清水雅仁、清島 満
    • Organizer
      第42回日本肝臓学会西部会
    • Related Report
      2017 Annual Research Report
  • [Presentation] レチノイド受容体遺伝子改変マウスにおける糖・脂質代謝異常2017

    • Author(s)
      白上洋平、境 浩康、清水雅仁、清島 満
    • Organizer
      日本レチノイド研究会第28回学術集会
    • Related Report
      2017 Annual Research Report
  • [Presentation] NASHおよび関連する肝発癌にSGLT-2阻害薬が及ぼす影響2017

    • Author(s)
      白上洋平、清水雅仁、清島 満
    • Organizer
      JDDW2017(第41回日本肝臓学会大会)
    • Related Report
      2017 Annual Research Report
  • [Presentation] The sodium glucose cotransporter 2 inhibitor tofogliflozin inhibits obesity-related liver tumorigenesis.2017

    • Author(s)
      白上洋平、小原功輝、大西雅也、境 浩康、田中卓二、清水雅仁、清島 満
    • Organizer
      第76回日本癌学会学術総会
    • Related Report
      2017 Annual Research Report
  • [Presentation] 糖尿病治療薬SGLT-2阻害薬による肥満関連肝発癌の抑制2017

    • Author(s)
      白上洋平、小原功輝、河内隆宏、境 浩康、田中卓二、清水雅仁、清島 満
    • Organizer
      第49回日本臨床分子形態学会総会・学術集会
    • Related Report
      2017 Annual Research Report
  • [Presentation] 糖尿病治療薬SGLT-2阻害薬が肝脂肪化および肝発癌に及ぼす影響2017

    • Author(s)
      白上洋平、小原功輝、境 浩康、田中卓二、清水雅仁、 清島 満
    • Organizer
      第24回肝細胞研究会
    • Related Report
      2017 Annual Research Report
  • [Presentation] 糖尿病治療薬による肥満に関連する肝発癌の抑制2017

    • Author(s)
      白上洋平、小原功輝、境 浩康、田中卓二、清水雅仁、清島 満
    • Organizer
      がん予防学術大会2017(第24回日本がん予防学会総会)
    • Related Report
      2017 Annual Research Report
  • [Presentation] パネルディスカッション「生活習慣病・メタボリックシンドロームからの消化器疾患」 酸化ストレスの制御による肥満関連大腸発癌の抑制2017

    • Author(s)
      白上洋平、清水雅仁、清島 満
    • Organizer
      第103回日本消化器病学会総会
    • Related Report
      2017 Annual Research Report
  • [Presentation] SGLT2阻害薬の脂肪肝および肝発癌に対する効果2017

    • Author(s)
      白上洋平、小原功輝、田中卓二、清水雅仁、清島 満
    • Organizer
      第7回肥満と消化器疾患研究会
    • Related Report
      2017 Annual Research Report
  • [Presentation] Preventive effects of the sodium glucose cotransporter 2 inhibitor tofogliflozin on liver tumorigenesis in obese mice.2017

    • Author(s)
      Shirakami Y, Obara K, Tanaka T, Shimizu M, Seishima M.
    • Organizer
      Asian Pacific Association for the Study of the Liver (APASL) Single Topic Conference
    • Related Report
      2017 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Preventive effects of the sodium glucose cotransporter 2 inhibitor tofogliflozin on liver tumorigenesis in obese and diabetic mice.2017

    • Author(s)
      Shirakami Y, Obara K, Ohnishi M, Ideta T, Sakai H, Tanaka T, Shimizu M, Seishima M.
    • Organizer
      108th American Association for Cancer Research (AACR) Annual Meeting
    • Related Report
      2017 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Preventive effects of pentoxifylline on hepatic tumorigenesis in a novel mouse model of NASH-related liver cancer.2016

    • Author(s)
      Shirakami Y, Sakai H, Ideta T, Takuji Tanaka, Shimizu M, Seishima M.
    • Organizer
      107th American Association for Cancer Research (AACR) Annual Meeting
    • Place of Presentation
      New Orleans, USA
    • Related Report
      2016 Research-status Report
    • Int'l Joint Research
  • [Presentation] Non-alcoholic steatohepatitis-related liver tumorigenesis is suppressed in mice lacking hepatic retinoid store.2016

    • Author(s)
      Shirakami Y, Ideta T, Sakai H, Tanaka T, Blaner WS, Shimizu M, Seishima M.
    • Organizer
      FASEB Science Research Conference (3rd International Conference on Retinoids)
    • Place of Presentation
      West Palm Beach, USA
    • Related Report
      2016 Research-status Report
    • Int'l Joint Research
  • [Presentation] FXR agonistによる大腸炎および大腸発癌の抑制2016

    • Author(s)
      白上洋平, 宮崎恒起, 出田貴康, 境 浩康, 渡部直樹, 田中卓二, 清水雅仁, 清島 満
    • Organizer
      第23回日本がん予防学会総会(がん予防学術大会2016)
    • Place of Presentation
      名古屋
    • Related Report
      2016 Research-status Report
  • [Presentation] NASH-related liver tumorigenesis is suppressed in mice lacking hepatic retinoid storage.2016

    • Author(s)
      Shirakami Y, Ideta T, Sakai H, Tanaka T, Blaner WS, Shimizu M, Seishima M.
    • Organizer
      The 12th JSH (Japan Society of Hepatology) Single Topic Conference
    • Place of Presentation
      金沢
    • Related Report
      2016 Research-status Report
  • [Presentation] Non-alcoholic steatohepatitis-related liver tumorigenesis is suppressed in mice lacking hepatic retinoid storage.2016

    • Author(s)
      白上洋平, 出田貴康, 境 浩康, 田中卓二, 清水雅仁, 清島 満
    • Organizer
      第74回日本癌学会学術総会
    • Place of Presentation
      横浜
    • Related Report
      2016 Research-status Report
  • [Presentation] 肝レチノイド貯蔵欠如マウスにおいて非アルコール性脂肪肝炎関連肝発癌は抑制される2016

    • Author(s)
      白上洋平, 出田貴康, 大西雅也, 境 浩康, 田中卓二, 清水雅仁, 清島 満
    • Organizer
      日本レチノイド研究会 第27回学術集会
    • Place of Presentation
      町田
    • Related Report
      2016 Research-status Report
  • [Presentation] ワークショップ「消化器疾患と代謝異常の関わり」 糖尿病治療薬を用いた肥満に関連する肝疾患の抑制2016

    • Author(s)
      白上洋平, 清水雅仁, 清島 満
    • Organizer
      JDDW2016(第58回日本消化器病学会大会)
    • Place of Presentation
      神戸
    • Related Report
      2016 Research-status Report

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Published: 2016-04-21   Modified: 2019-03-29  

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