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identifying the antigen of IgG4 related disease

Research Project

Project/Area Number 16K19339
Research Category

Grant-in-Aid for Young Scientists (B)

Allocation TypeMulti-year Fund
Research Field Gastroenterology
Research InstitutionKobe University (2017)
Kyoto University (2016)

Principal Investigator

Shiokawa Masahiro  神戸大学, 科学技術イノベーション研究科, 特別研究員(PD) (50737880)

Project Period (FY) 2016-04-01 – 2018-03-31
Project Status Completed (Fiscal Year 2017)
Budget Amount *help
¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000)
Fiscal Year 2017: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Fiscal Year 2016: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
KeywordsIgG4 / 自己免疫性膵炎 / 抗原 / IgG4関連疾患 / 免疫学
Outline of Final Research Achievements

Subcutaneous injection of patient IgG, but not control IgG, resulted in pancreatic and salivary gland injuries. Pancreatic injury was also induced by injecting patient IgG1 or IgG4, with more destructive changes induced by IgG1 than by IgG4. The potent pathogenic activity of patient IgG1 was significantly inhibited by simultaneous injection of patient IgG4. Binding of patient IgG, especially IgG1 and IgG4, to pancreatic tissue was confermed in both the mouse model and AIP tissue samples. Next, we identified this target antigen as laminin 511.

Report

(3 results)
  • 2017 Annual Research Report   Final Research Report ( PDF )
  • 2016 Research-status Report
  • Research Products

    (6 results)

All 2017 2016

All Journal Article (1 results) (of which Peer Reviewed: 1 results,  Acknowledgement Compliant: 1 results) Presentation (4 results) (of which Int'l Joint Research: 3 results,  Invited: 3 results) Book (1 results)

  • [Journal Article] Pathogenicity of Immunoglobulin G in Patients with IgG4-related Disease.2016

    • Author(s)
      Shiokawa M, Kodama Y, Kuriyama K, Yoshimura K, Tomono T, Morita T, Kakiuchi N, Matsumori T, Mima A, Nishikawa Y, Ueda T, Tsuda M, Yamauchi Y, Minami R, Sakuma Y, Ota Y, Maruno T, Kurita A, Sawai Y, Tsuji Y, Uza N, Matsumura K, Watanabe T, Notohara K, Tsuruyama T, Seno H, Chiba T.
    • Journal Title

      Gut

      Volume: 未定 Issue: 8 Pages: 3292-3301

    • DOI

      10.1136/gutjnl-2015-310336

    • Related Report
      2016 Research-status Report
    • Peer Reviewed / Acknowledgement Compliant
  • [Presentation] Pathogenic Role of IgG in Patients With IgG4-Related Disease2017

    • Author(s)
      Shiokawa Masahiro, Kodama Yuzo, Seno Hiroshi, Chiba Tsutomu.
    • Organizer
      IPRF 2017
    • Related Report
      2017 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] Risk of cancer in patients with autoimmune pancreatitis2017

    • Author(s)
      Shiokawa Masahiro, Kodama Yuzo, Seno Hiroshi, Chiba Tsutomu
    • Organizer
      PRF 2017
    • Related Report
      2017 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] Is serum IgG in patients with AIP pathogenic ?2017

    • Author(s)
      Shiokawa Masahiro, Kodama Yuzo, Seno Hiroshi, Chiba Tsutomu
    • Organizer
      Third International Symposium on IgG4-RD and Fibrosis
    • Related Report
      2017 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] 自己免疫性膵炎の自己抗原同定2017

    • Author(s)
      塩川 雅広 児玉 裕三 妹尾 浩 千葉 勉
    • Organizer
      第48回日本膵臓学会大会
    • Related Report
      2017 Annual Research Report
  • [Book] 【胆膵疾患診療の進歩】 炎症性疾患 自己免疫性膵炎・IgG4関連疾患における病因・病態の進歩 新規標的抗原を中心に2017

    • Author(s)
      塩川雅広、児玉裕三、千葉勉
    • Total Pages
      4
    • Publisher
      医歯薬出版株式会社
    • Related Report
      2017 Annual Research Report

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Published: 2016-04-21   Modified: 2019-03-29  

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