The role of hepatocyte Grb2-associated binder 1 in impaired liver regeneration of NALFD
| Project/Area Number |
16K19341
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Gastroenterology
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| Research Institution | Osaka University |
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Principal Investigator |
FURUTA KUNIMARO 大阪大学, 医学部附属病院, 特任助教(常勤) (50773834)
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| Project Period (FY) |
2016-04-01 – 2018-03-31
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| Project Status |
Completed (Fiscal Year 2017)
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| Budget Amount *help |
¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000)
Fiscal Year 2017: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2016: ¥2,730,000 (Direct Cost: ¥2,100,000、Indirect Cost: ¥630,000)
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| Keywords | Gab1 / NAFLD / 肝再生 / 細胞死 / Gab１ / Gab2 |
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| Outline of Final Research Achievements |
Grb2-associated binder 1 (Gab1) plays a crucial role in the live regeneration. Liver regeneration is known to be impaired in non-alcoholic fatty liver disease (NAFLD) patients. However, the role of Gab1 in impaired liver regeneration in NAFLD has remained unclear. To investigate this issue, we examined the liver injury of hepatocyte specific Gab1 conditional knockout (KO) mice of in murine NAFLD models. Wild type (WT) and KO mice were fed with high-fat and high-cholesterol (HFHC) diet or methionine- and choline-deficient (MCD) diet for 8 weeks. In a HFHC diet model, KO mice showed a significant increase in body weight and hepatic cholesterol content compared with WT mice, however, did not show any difference in serum ALT levels. In contrast, in a MCD diet model, KO mice showed a significant increase in serum ALT levels compared with WT mice. The data indicate the possible role of Gab1 in hepatic lipid metabolism and hepatocyte injury in NAFLD.
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Report
(3 results)
Research Products
(13 results)
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[Journal Article] Increased expression of Forkhead box M1 transcription factor is associated with clinicopathological features and confers a poor prognosis in human hepatocellular carcinoma.2017
Author(s)
Egawa M, Yoshida Y, Ogura S, Kurahashi T, Kizu T, Furuta K, Kamada Y, Chatani N, Hamano M, Kiso S, Hikita H, Tatsumi T, Eguchi H, Nagano H, Doki Y, Mori M, Takehara T
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Journal Title
Hepatol Res.
Volume: 印刷中
Issue: 11
Pages: 1196-1205
DOI
Related Report
Peer Reviewed / Acknowledgement Compliant
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[Journal Article] Gab1 adaptor protein acts as a gatekeeper to balance hepatocyte death and proliferation during acetaminophen-induced liver injury in mice.2016
Author(s)
Furuta K, Yoshida Y, Ogura S, Kurahashi T, Kizu T, Maeda S, Egawa M, Chatani N, Nishida K, Nakaoka Y, Kiso S, Kamada Y, Takehara T.
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Journal Title
Hepatology
Volume: 63
Issue: 4
Pages: 1340-1355
DOI
Related Report
Peer Reviewed / Acknowledgement Compliant
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[Presentation] Metabolic regulation of FoxM1 transcription factor by mevalonate-Rho pathways in human hepatocarcinoma.2016
Author(s)
Satoshi Ogura, Yuichi Yoshida, Tomohide Kurahashi, Mayumi Egawa, Kunimaro Furuta, Shinichi Kiso, Yoshihiro Kamada, Hayato Hikita, Tomohide Tatsumi and Tetsuo Takehara.
Organizer
The Liver Meeting 2016 - AASLD
Place of Presentation
HYNES CONVENTION CENTER, BOSTON, MA, USA
Year and Date
2016-11-11
Related Report
Int'l Joint Research
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[Presentation] Hepatic overexpression of oncogenic FoxM1 transcription factor promotes hepatocyte death and hepatic inflammation in mice.2016
Author(s)
Tomohide Kurahashi, Yuichi Yoshida, Satoshi Ogura, Mayumi Egawa, Kunimaro Furuta, Yoshihiro Kamada, Shinichi Kiso, Hayato Hikita, Tomohide Tatsumi, Tetsuo Takehara.
Organizer
The Liver Meeting 2016 - AASLD
Place of Presentation
HYNES CONVENTION CENTER, BOSTON, MA, USA
Year and Date
2016-11-11
Related Report
Int'l Joint Research
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