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JMJD2A as a novel predictor for chemotherapy response in metastatic gastric cancer

Research Project

Project/Area Number 16K19348
Research Category

Grant-in-Aid for Young Scientists (B)

Allocation TypeMulti-year Fund
Research Field Gastroenterology
Research InstitutionThe University of Tokushima

Principal Investigator

NAKAGAWA Tadahiko  徳島大学, 大学院医歯薬学研究部(医学系), 特任助教 (40634275)

Project Period (FY) 2016-04-01 – 2018-03-31
Project Status Completed (Fiscal Year 2017)
Budget Amount *help
¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000)
Fiscal Year 2017: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2016: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
Keywords胃癌 / JMJD2A / 抗癌剤感受性因子 / 抗癌剤感受性 / エピジェネティック調節
Outline of Final Research Achievements

There is no appropriate predictor of chemotherapeutic treatment for metastatic gastric cancer (MGC). We have selected 15 candidate predictor genes by genome-wide association study using gastric cancer tissues of responders and non-responders to S-1, cisplatin and docetaxel (DCS) therapy. Knockdown experiments of these 15 genes with siRNA revealed that JMJD2A is the best predictor for response to these drugs. When IC50s of 5-FU, cisplatin and docetaxel in gastric cancer cell line that was knocked down by siRNA were analyzed by WST assay, they were significantly higher than those in the control cells. Subsequently, we investigated JMJD2A expression in the biopsy specimens from 29 patients with MGC before treatment by immunohistochemistry. There was a significant correlation between immunostaining score and reduction rate of the tumors evaluated after 2 courses treatment with DCS therapy. Our data strongly suggest that JMJD2A is a promising predictor of response to these drugs in MGC.

Report

(3 results)
  • 2017 Annual Research Report   Final Research Report ( PDF )
  • 2016 Research-status Report
  • Research Products

    (2 results)

All 2017 2016

All Presentation (2 results)

  • [Presentation] ヒストン脱メチル化酵素JMJD2Aは切除不能進行胃癌において CCDC8の発現を調節することで薬剤感受性を制御している2017

    • Author(s)
      中川 忠彦, 棚橋 俊仁, 木村 哲夫, 岡本 耕一, 谷口 達哉, 村山典聡 , 田中 宏典, 坂東 良美, 佐藤 康史, 六車 直樹, 高山 哲治
    • Organizer
      第76回日本癌学会学術総会
    • Related Report
      2017 Annual Research Report
  • [Presentation] ヒストン脱メチル化酵素JMJD2Aは切除不能進行胃癌における新しい治療効果予測因子である.2016

    • Author(s)
      中川 忠彦, 木村 哲夫, 岡本 耕一, 曽我部 正弘, 宮本 弘志, 坂東 良美, 六車 直樹, 岡久 稔也, 高山 哲治
    • Organizer
      第75回日本癌学会学術総会
    • Place of Presentation
      パシフィコ横浜(神奈川県・横浜市)
    • Year and Date
      2016-10-06
    • Related Report
      2016 Research-status Report

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Published: 2016-04-21   Modified: 2019-03-29  

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