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Elucidating the mechanism of ameliorated liver disease and HBs antigen elimination by nucleos(t)ide analogs in chronic hepatitis B patients

Research Project

Project/Area Number 16K19360
Research Category

Grant-in-Aid for Young Scientists (B)

Allocation TypeMulti-year Fund
Research Field Gastroenterology
Research InstitutionNagoya City University

Principal Investigator

HAYASHI Sanae  名古屋市立大学, 大学院医学研究科, 研究員 (10597587)

Research Collaborator ISOGAWA Masanori  名古屋市立大学, 大学院医学研究科, 助教
TANAKA Yasuhito  名古屋市立大学, 大学院医学研究科, 教授
Project Period (FY) 2016-04-01 – 2018-03-31
Project Status Completed (Fiscal Year 2017)
Budget Amount *help
¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000)
Fiscal Year 2017: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Fiscal Year 2016: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
KeywordsB型肝炎ウイルス / 核酸アナログ / NK細胞 / 肝障害 / 免疫 / 炎症 / 肝臓学 / HBs抗原
Outline of Final Research Achievements

In vitro study revealed that CD56bright+TRAIL+ NK cells induce hepatocyte damage in a dose dependent manner, and that HBV infected hepatocytes cocultured with CD56bright+TRAIL+ NK cells promote the chemotaxis of the CD56bright+TRAIL+ NK cells. In an age and gender-matched case study, we analyzed the dynamic changes of an inflammatory cytokine, IP10, in the sera of chronic HBV patients before and after NAs treatment (ETV or TDF). After 12 and 24 weeks of NAs treatment, serum IP10 level was decreased in chronic HBV patients treated with TDF. No significant change was observed in patients treated with ETV.

Report

(3 results)
  • 2017 Annual Research Report   Final Research Report ( PDF )
  • 2016 Research-status Report
  • Research Products

    (4 results)

All 2017

All Presentation (4 results) (of which Int'l Joint Research: 1 results)

  • [Presentation] 新規抗HBV薬候補化合物CFCPのin vitroウイルス学・細胞生物学的特性2017

    • Author(s)
      鍬田伸好, 林佐奈衣, 熊本浩樹, 服部真一朗, 橋本麻衣, 林宏典, 松田幸樹, 青木学, 前田賢次, 小田切優樹, 田中靖人, 満屋裕明.
    • Organizer
      第27回抗ウイルス療法学会学術集会・総会
    • Related Report
      2017 Annual Research Report
  • [Presentation] 新規4'-置換-7-デアザプリンヌクレオシド類の合成と抗HBV活性評価2017

    • Author(s)
      苫谷晃太, 大野裕太郎, 杉原匠, 山田浩平, 鍬田伸好, 林佐奈衣, 村上周子, 前田賢次, 田中靖人, 満屋裕明.
    • Organizer
      第27回抗ウイルス療法学会学術集会・総会
    • Related Report
      2017 Annual Research Report
  • [Presentation] Entecavirよりも持続的かつ強力に抗HBV活性を有する新規核酸アナログCFCPの同定2017

    • Author(s)
      林佐奈衣, 鍬田伸好, 熊本浩樹, 村上周子, 尾曲克己, 五十川正記, 前田賢次, 満屋裕明, 田中靖人.
    • Organizer
      第27回抗ウイルス療法学会学術集会・総会.
    • Related Report
      2017 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Novel Nucleosides, CMCP and CFCP, Potently Block the Infectivity and Replication of Wild-type and Drug-resistant HBVs in Culture and in Human-liver-chimeric Mice and Show Potential QW or Q2W.2017

    • Author(s)
      Higashi-kuwata N, Hayashi S, Kumamoto H, Kohgo S, Das D, Bulut H, Sarafianos S, Tanaka Y, Mitsuya H.
    • Organizer
      HEP DART
    • Related Report
      2017 Annual Research Report

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Published: 2016-04-21   Modified: 2019-03-29  

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