Beneficial Effects of Bioabsorbable Polymer DES on Coronary Hyperconstricting Responses
Project/Area Number |
16K19384
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Research Category |
Grant-in-Aid for Young Scientists (B)
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Allocation Type | Multi-year Fund |
Research Field |
Cardiovascular medicine
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Research Institution | Tohoku University |
Principal Investigator |
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Research Collaborator |
Shimokawa Hiroaki
Matsumoto Yasuharu
Uzuka Hironori
Ohyama Kazuma
Amamizu Hirokazu
Tuchiya Satoshi
Tearney Guillermo J.
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Project Period (FY) |
2016-04-01 – 2019-03-31
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Project Status |
Completed (Fiscal Year 2018)
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Budget Amount *help |
¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000)
Fiscal Year 2018: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2017: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2016: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
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Keywords | 薬剤溶出性ステント / 経皮的冠動脈インターベンション / 虚血性心疾患 / 外膜 / 冠攣縮 / ステント / OCT / 炎症 / ポリマー / Vasa vasorum / 光干渉 / リンパ管 / 内皮細胞 / アセチルコリン / PET / 冠動脈外膜 |
Outline of Final Research Achievements |
Drug-eluting stent (DES) has potentially reduced the rate of in-stent restenosis. Among those who underwent percutaneous coronary intervention (PCI) with DES, some are suffer from unremitting chest pain even after DES implantation, and then limit their quality of life. We have demonstrated that DES induces coronary hyperconstricting responses through adventitial inflammation caused by non-biocompatible durable polymer. This study examined whether or not newly developed bioabsorbable polymer DES (BP-DES) suppresses the DES-induced coronary hyperconstriction when compared to durable-polymer DES (DP-DES). In the swine study, BP-DES allowed to prevent adventitial inflammation around polymers followed by cancellation of coronary hyperconstriction in swine in vivo. Second, in the human study, BP-DES significantly reduced optical coherence tomography (OCT) delineated adventitial vasa vasorum augmentation as compared to DP-DES in patients in vivo.
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Academic Significance and Societal Importance of the Research Achievements |
薬剤溶出性ステント(DES)留置によって冠動脈狭窄症を解除しても、約20-40%の症例に胸痛の再燃が起こるといわれる。持続性胸痛は患者の生活の質を著しく損ない、薬剤増量や入院によるカテーテル再検査が必要となり、医療費の面で悪影響を及ぼす。我々は持続性胸痛の主因がDES留置後の冠動脈過収縮反応であること、薬剤溶出を一定化させるポリマーがその本態であることを報告した。今回、生体吸収性の向上したポリマーDES(BP-DES)が冠動脈過収縮の予防効果をもつことを証明した。BP-DESによって冠動脈過収縮を制御できれば、薬剤増量や再入院を減らすことで患者の生活の質と医療費削減の両面に効果を期待できる。
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Report
(4 results)
Research Products
(32 results)
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[Journal Article] Renal Denervation Suppresses Coronary Hyperconstricting Responses After Drug-Eluting Stent Implantation in Pigs In Vivo Through the Kidney-Brain-Heart Axis2017
Author(s)
Uzuka H, Matsumoto Y, Nishimiya K, Ohyama K, Suzuki H, Amamizu H, Morosawa S, Hirano M, Shindo T, Kikuchi Y, Hao K, Shiroto T, Ito K, Takahashi J, Fukuda K, Miyata S, Funaki Y, Ishibashi-Ueda H, Yasuda S, Shimokawa H
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Journal Title
Arteriosclerosis, Thrombosis, and Vascular Biology
Volume: 37
Issue: 10
Pages: 1869-1880
DOI
Related Report
Peer Reviewed / Int'l Joint Research
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[Journal Article] Focal Vasa Vasorum Formation in Patients With Focal Coronary Vasospasm – An Optical Frequency Domain Imaging Study –2016
Author(s)
Nishimiya K, Matsumoto Y, Uzuka H, Ohyama K, Hao K, Tsuburaya R, Shiroto T, Takahashi J, Ito K, Shimokawa H
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Journal Title
Circulation Journal
Volume: 80
Issue: 10
Pages: 2252-2254
DOI
NAID
ISSN
1346-9843, 1347-4820
Related Report
Peer Reviewed
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[Journal Article] Increased Coronary Perivascular Adipose Tissue Volume in Patients With Vasospastic Angina2016
Author(s)
Ohyama K, Matsumoto Y, Nishimiya K, Hao K, Tsuburaya R, Ota H, Amamizu H, Uzuka H, Takahashi J, Ito K, Shimokawa H
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Journal Title
Circulation Journal
Volume: 80
Issue: 7
Pages: 1653-1656
DOI
NAID
ISSN
1346-9843, 1347-4820
Related Report
Peer Reviewed
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[Journal Article] Beneficial effects of novel bioabsorbable polymer coating on enhanced coronary vasoconstricting responses after drug-eluting stent implantation in pigs in vivo2016
Author(s)
Nishimiya K, Matsumoto Y, Uzuka H, Ogata T, Hirano M, Shindo T, Haseve Y, Tsuburaya R, Shiroto T, Takahashi J, Ito K, Shimokawa H
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Journal Title
Journal of American College of Cardiology: Cardiovascular Intervnetions
Volume: 9
Issue: 3
Pages: 281-291
DOI
Related Report
Peer Reviewed
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[Presentation] High-resolution micro-OCT for endothelial cell visualization in the coronary arteries2019
Author(s)
Kensuke Nishimiya, Osman O. Ahsen, Biwei Yin, Zhonglie Piao, Jiheun Ryu, Hany Osman, Gargi Sharma, Hui Min Leung, Chia-Pin Liang, Joseph A. Gardecki, Guillermo J. Tearney
Organizer
SPIE 2018
Related Report
Int'l Joint Research
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[Presentation] High-resolution Intravascular OCT-NIRF Molecular Imaging for In Vivo Assessment of Inflammation in Atherosclerosis and Vascular Injury2018
Author(s)
Zhonglie Piao, Kanwarpal Singh, Mohammed Chowdhury, Joseph Gardecki, Kensuke Nishimiya, Biwei Yin, Matthew Beatty, Ara Bablouzian, Sarah Giddings, Adam Mauskapf, Farouc Amin Jaffer, Guillermo Tearney
Organizer
TCT 2018
Related Report
Int'l Joint Research
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[Presentation] Important roles of cardiac lymphatic vessels in the regulation of coronary vasomotion after DES implantation in pigs in vivo.2018
Author(s)
Hirokazu Amamizu, Yasuharu Matsumoto, Susumu Morosawa, Kazuma Ohyama, Hironori Uzuka, Michinori Hirano, Jun Sugisawa, Satoshi Tsuchiya, Kensuke Nishimiya, Moyuru Hayashi, Yoshiko Kawai, Shimokawa H.
Organizer
ESC 2018
Related Report
Int'l Joint Research
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[Presentation] Evidence for Enhanced Inflammation of Coronary Adventitia and Perivascular Adipose Tissue in Patients with Vasospastic Angina -A Multi-modality Imaging Study-2018
Author(s)
Ohyama K, Matsumoto Y, Takanami K, Ota H, Nishimiya K, Sugisawa J, Tsuchiya S, Amamizu H, Uzuka H, Suda A, Shindo T, Kikuchi Y, Hao K, Tsuburaya R, Takahashi J, Miyata S, Sakata Y, Takase K, Shimokawa H.
Organizer
日本循環器学会学術集会総会 2018
Related Report
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[Presentation] Renal Denervation Suppresses Coronary Hyperconstricting Responses after Drug-Eluting Stent Implantation in Pigs in Vivo through the Kidney-Brain-Heart Axis2018
Author(s)
Uzuka H, Matsumoto Y, Nishimiya K, Ohyama K, Amamizu H, Morosawa S, Hirano M, Shindo T, Kikuchi Y, Hao K, Shiroto T, Takahashi J, Shimokawa H.
Organizer
日本循環器学会学術集会総会 2018
Related Report
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[Presentation] Absence of Adventitial Vasa Vasorum Formation at the Coronary Segment With Myocardial Bridge -An Optical Coherence Tomography Study2017
Author(s)
Nishimiya K, Matsumoto Y, Wang H, Piao Z, Ohyama K, Uzuka H, Hao K, Tsuburaya R, Takahashi J, Ito K, Shimokawa H.
Organizer
AHA Scientific Session 2017
Related Report
Int'l Joint Research
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[Presentation] Evidence for Enhanced Inflammation of Coronary Adventitia and Perivascular Adipose Tissue With Altered Disease Activity in Vasospastic Angina Patients -A Multi-modality Imaging Study2017
Author(s)
Ohyama K, Matsumoto Y, Takanami K, Ota H, Nishimiya K, Sugisawa J, Tsuchiya S, Amamizu H, Uzuka H, Suda A, Shindo T, Kikuchi Y, Hao K, Takahashi J, Sakata Y, Shimokawa H.
Organizer
AHA Scientific Session 2017
Related Report
Int'l Joint Research
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[Presentation] Evidence for enhanced inflammation of coronary adventitia and perivascular adipose tissue in patients with vasospastic angina -A multi-modality imaging study-2017
Author(s)
Ohyama K, Matsumoto Y, Takanami K, Ota H, Nishimiya K, Sugisawa J, Amamizu H, Uzuka H, Suda A, Shindo T, Kikuchi Y, Hao K, Takahashi J, Sakata Y, Shimokawa H.
Organizer
European Cardiology Congress 2017
Related Report
Int'l Joint Research
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[Presentation] Evidence for involvement of inflammatory changes of perivascular adipose tissue in the pathogenesis of DES-induced hyperconstricting responses in pigs in vivo - impact of 18F-FDG PET imaging2016
Author(s)
Ohyama K, Matsumoto Y, Amamizu H, Uzuka H, Nishimiya K, Morosawa S, Hirano M, Watabe H, Funaki Y, Takahashi J, Ito K, Shimokawa H
Organizer
ESC Congress 2016
Place of Presentation
Roma (イタリア)
Year and Date
2016-08-27
Related Report
Int'l Joint Research
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[Book] 狭心症2017
Author(s)
下川 宏明
Total Pages
243
Publisher
最新医学 別冊
Related Report