| Budget Amount *help |
¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000)
Fiscal Year 2017: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Fiscal Year 2016: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
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| Outline of Final Research Achievements |
Heart failure is still a disease with high morbidity and high mortality and the elucidation of the pathophysiology is imperative. We have previously revealed that murine cardiac resident macrophages are indispensable in homeostasis of heart, and Amphiregulin, which is expressed exclusively in cardiac macrophages has a cardio-protective role. I performed ATAC-seq of cardiac macrophages to analyze the transcriptional regulation of these cell-specific genes. As compared to heart failure model and aged mice, I found that the epigenome of cardiac macrophages has altered in the transition from fetal liver monocyte-derived to bone marrow monocyte-derived and with aging of bone marrow. I think the intervention to the molecular mechanism which led to these epigenomic changes could be the novel target of heart failure.
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