Identification and functional analysis for molecule X via comprehensive genetic analysis
| Project/Area Number |
16K19394
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Cardiovascular medicine
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| Research Institution | Kanazawa University |
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Principal Investigator |
Tada Hayato 金沢大学, 附属病院, 助教 (90623653)
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| Project Period (FY) |
2016-04-01 – 2019-03-31
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| Project Status |
Completed (Fiscal Year 2018)
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| Budget Amount *help |
¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000)
Fiscal Year 2018: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2017: ¥780,000 (Direct Cost: ¥600,000、Indirect Cost: ¥180,000)
Fiscal Year 2016: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
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| Keywords | 家族性高コレステロール血症 / 網羅的遺伝子解析 / エクソーム解析 |
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| Outline of Final Research Achievements |
We found that rare as well as deleterious mutations in genes known as causative genes for recessive lipid disorders were associated with increased LDL cholesterol level among Japanese patients with hyper LDL cholesterolemia.
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| Academic Significance and Societal Importance of the Research Achievements |
本邦における高LDLコレステロール血症において、これまでの知見と比較し多彩な遺伝子異常が寄与することを見出した。従って、このような背景を検討するにあたっては、網羅的なスクリーニングシステムを使用する必要がある。
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Report
(4 results)
Research Products
(13 results)
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[Journal Article] Aortic Root Calcification Score as an Independent Factor for Predicting Major Adverse Cardiac Events in Familial Hypercholesterolemia2018
Author(s)
Okada H, Tada H, Hayashi K, Kawashima H, Takata T, Sakata K, Nohara A, Mabuchi H, Yamagishi M, Kawashiri MA
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Journal Title
Journal of Atherosclerosis and Thrombosis
Volume: 25
Issue: 7
Pages: 634-642
DOI
NAID
ISSN
1340-3478, 1880-3873
Year and Date
2018-07-01
Related Report
Peer Reviewed / Open Access
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