Study of clinical usefulness as a biomarker of SDF-1alpha in cardiovascular diseases

• Project/Area Number: 16K19395
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Multi-year Fund
• Research Field: Cardiovascular medicine
• Research Institution: University of Yamanashi
• Principal Investigator: UEMATSU Manabu 山梨大学, 大学院総合研究部, 助教 (00622151)
• Project Period (FY): 2016-04-01 – 2019-03-31
• Project Status: Completed (Fiscal Year 2018)
• Budget Amount: ¥3,640,000 (Direct Cost: ¥2,800,000、Indirect Cost: ¥840,000); Fiscal Year 2018: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000); Fiscal Year 2017: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000); Fiscal Year 2016: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
• Keywords: SDF-1α / バイオマーカー / 慢性冠動脈疾患 / 腎機能障害 / アンギオテンシン受容体拮抗薬 / 腎不全 / 冠動脈疾患 / アンギオテンシンⅡ受容体拮抗薬 / 慢性腎臓病 / 陳旧性心筋梗塞 / 予後予測因子 / 左室リモデリング / 急性心筋梗塞 / 心不全

Outline of Final Research Achievements

Stromal cell-derived factor-1α (SDF-1α) is an inflammatory chemokine that has been reported to be deeply involved in the pathogenesis of cardiovascular disease. This study aimed to exam the clinical significance of SDF-1α in cardiovascular disease. As a result, we clarified (1) high levels of SDF-1α in the peripheral blood predict secondary cardiovascular events in patients with a history of myocardial infarction, (2) Angiotensin receptor antagonists suppress the production of SDF-1α from the myocardium, (3) high levels of SDF-1α predict short-term progression of renal dysfunction. SDF-1α is deeply involved in cardiovascular diseases and may be one of the new biomarkers

Academic Significance and Societal Importance of the Research Achievements

心血管病の病態には、炎症の持続が深くかかわっていることが知られているが、これまで炎症マーカーの一つであるSDF-1αの臨床的な意義についてほとんど明らかになっていなかった。今回の研究でSDF-1αが心疾患のみならず、腎不全とも関連していることが明らかになったことで、SDF-1αが心腎連関を含めた心血管病全体の病態に深く関わっていることが示唆された。そのためSDF-1αは循環器疾患の新しいバイオマーカーになりうる可能性があることがわかった。今後さらに大規模な研究で検討を行ったり、他の多くのバイオマーカーとの関連を検討していくことで、心血管病の病態の解明や予後改善につながる可能性がある。

Research Products

• [Journal Article] High levels of stromal cell-derived factor-1α predict short-term progression of renal dysfunction in patients with coronary artery disease. (2019)
  • Author(s): Uematsu M, Nakamura T, Yoshizaki T, Watanabe Y, Deyama J, Watanabe K, Kobayashi T, Fujioka D, Saito Y, Nakamura K, Kawabata K, Obata JE, Kugiyama K.
  • Journal Title: Clin Exp Nephrol. Volume: Epub ahead of print Issue: 7 Pages: 920-927
  • DOI: 10.1007/s10157-019-01722-9
  • Peer Reviewed
• [Journal Article] Angiotensin II receptor blockers suppress the release of stromal cell-derived factor-1a from infarcted myocardium in patients with acute myocardial infarction (2018)
  • Author(s): Toru Yoshizaki, Manabu Uematsu, Jun-ei Obata, Takamitsu Nakamura, Daisuke Fujioka, Kazuhiro Watanabe, Kazuto Nakamura, Kiyotaka Kugiyama
  • Journal Title: Journal of Cardiology Volume: 71 Pages: 367-374
  • Peer Reviewed / Open Access
• [Journal Article] High levels of stromal cell-derived factor-1a predict secondary cardiac events in stable patients with a history of myocardial infarction (2017)
  • Author(s): Satoshi Matsuoka, Manabu Uematsu, Takamitsu Nakamura, Takuya Shimizu, Mika Futamata, Jun-ei Obata, Daisuke Fujioka, Kazuto Nakamura, Toru Yoshizaki, Kiyotaka Kugiyama
  • Journal Title: Journal of Cardiology Volume: 69 Pages: 320-325
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Presentation] Myocardial Production of Follistatin-Like 1 is Associated With Left Ventricular Adverse Remodeling in Survivors of Acute Myocardial Infarction. (2018)
  • Author(s): Manabu UEMASTU, Kazuto NAKAMURA, Takamitsu NAKAMURA, Toru YOSHIZAKI, Yosuke WATANABE, Juntaro DEYAMA, Kazuhiro WATANABE, Tsuyoshi KOBAYASHI, Daisuke Fujioka, Yukio SAITO, Kenichi KAWABATA, Jun-ei OBATA, Kiyotaka KUGIYAMA
  • Organizer: American Heart Association Scientific Sessions 2018
  • Int'l Joint Research
• [Presentation] Stromal Cell-Derived Factor-1α is Associated with Future Renal Dysfunction in Patients with Coronary Artery Disease (2018)
  • Author(s): Manabu Uematsu, Takamitsu Nakamura, Toru Yoshizaki, Chifumi Iizuka, Mika Futamata, Yosuke Watanabe, Juntaro Deyama, Tsuyoshi Kobayashi, Daisuke Fujioka, Yukio Saito, Kazuto Nakamura, Kenichi Kawabata, Jun-ei Obata, Kiyotaka Kugiyama.
  • Organizer: The 82nd Annual Scientific Meeting of the Japanese Circulation Society（JCS2018）
• [Presentation] High levels of stromal cell-derived factor-1a predict secondary cardiac events in stable patients with a history of myocardial infarction (2017)
  • Author(s): Satoshi Matsuoka, Manabu Uematsu, Takamitsu Nakamura, Takuya Shimizu, Mika Futamata, Jun-ei Obata, Daisuke Fujioka, Kazuto Nakamura, Toru Yoshizaki, Kiyotaka Kugiyama
  • Organizer: The 81st Annual Scientific Meeting of the Japanese circulation society
  • Place of Presentation: 石川県立音楽堂(金沢、石川)
  • Year and Date: 2017-03-17
• [Presentation] Stromal Cell-derived Factor-1α is Associated With Future Renal Dysfunction in Patients With Coronary Artery Disease (2017)
  • Author(s): Manabu Uematsu, Takamitsu Nakamura, Toru Yoshizaki, Chifumi Iizuka, Mika Futamata, Yosuke Watanabe, Juntaro Deyama, Kazuhiro Watanabe, Tsuyoshi Kobayashi, Daisuke Fujioka, Yukio Saito, Kazuto Nakamura, Kenichi Kawabata, Jun-ei Obata, Kiyotaka Kugiyama
  • Organizer: American Heart Association Scientific Sessions 2017
  • Int'l Joint Research
• [Presentation] High levels of stromal cell-derived factor-1a predict secondary cardiac events in stable patients with a history of myocardial infarction (2016)
  • Author(s): Satoshi Matsuoka, Manabu Uematsu, Takamitsu Nakamura, Takuya Shimizu, Mika Futamata, Jun-ei Obata, Daisuke Fujioka, Kazuto Nakamura, Toru Yoshizaki, Kiyotaka Kugiyama
  • Organizer: American Heart Association Scientific Sessions 2017
  • Place of Presentation: New Orleans Ernest N. Morial Convention Center(USA)
  • Year and Date: 2016-11-12
  • Int'l Joint Research
• [Remarks] 山梨大学医学部 循環器・呼吸器内科 ホームページ
  • URL: https://yamanashi-2nai.com/
• [Remarks] 山梨大学医学部 循環器・呼吸器内科 ホームページ
  • URL: http://www.med.yamanashi.ac.jp/clinical/intern02