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Mechanism Analysis of Microcirculation Disorder in Hypertrophic Cardiomyopathy

Research Project

Project/Area Number 16K19398
Research Category

Grant-in-Aid for Young Scientists (B)

Allocation TypeMulti-year Fund
Research Field Cardiovascular medicine
Research InstitutionNagoya University

Principal Investigator

Ryota Morimoto  名古屋大学, 医学部附属病院, 病院助教 (00755499)

Project Period (FY) 2016-04-01 – 2019-03-31
Project Status Completed (Fiscal Year 2018)
Budget Amount *help
¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000)
Fiscal Year 2017: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2016: ¥2,860,000 (Direct Cost: ¥2,200,000、Indirect Cost: ¥660,000)
Keywords肥大型心筋症 / アンモニアPET / 微小循環不全 / 13N アンモニアPET / 13N-アンモニアPET / 血管新生関連因子 / 収縮頻度連関
Outline of Final Research Achievements

Hypertrophic cardiomyopathy (HCM) is characterized by gradual thickening of the cardiac muscle and impairing myocardial blood flow (MBF). We assessed MBF undergoing NH3-PET and in order to perform transmural layer analysis, the reconstructed images were transferred to a workstation using PMOD software. We enrolled 17 control patients and 16 HCM patients. Even though there was no significant difference between control patients and HCM patients in subendocardial MBF at rest, hyperemic subendocardial MBF in HCM was significantly lower than normal patients (1.159±0.144 vs 1.422±0.202, p=0.0002). Furthermore, HOCM was significantly lower than apical HCM patients (1.32±0.18 vs 1.92±0.49). These results might relate the major cause of sudden cardiac death due to latent myocardial damage in HOCM patients.

Academic Significance and Societal Importance of the Research Achievements

循環不全とさまざまなパラメーターの直接的な関連が明らかとなれば、心筋症進展機序の解明に向けて新たな概念を提唱しうる可能性があり、予後予測や拡張障害に対する心不全治療として微小循環をターゲットにする新たな創薬について検討することが可能となり、臨床応用意義 は大きく、学術的波及効果も期待できる。

Report

(4 results)
  • 2018 Annual Research Report   Final Research Report ( PDF )
  • 2017 Research-status Report
  • 2016 Research-status Report
  • Research Products

    (4 results)

All 2017 2016

All Journal Article (2 results) (of which Peer Reviewed: 2 results) Presentation (1 results) (of which Int'l Joint Research: 1 results) Funded Workshop (1 results)

  • [Journal Article] The Biphasic Force-Frequency Relation Predicts Primary Cardiac Events in Patients with Hypertrophic Cardiomyopathy.2017

    • Author(s)
      Ryota Morimoto
    • Journal Title

      Circulation Journal

      Volume: 24;81(3) Pages: 368-375

    • NAID

      130005243014

    • Related Report
      2016 Research-status Report
    • Peer Reviewed
  • [Journal Article] Myocardial Contractile Reserve Predicts Left Ventricular Reverse Remodeling and Cardiac Events in Dilated Cardiomyopathy.2017

    • Author(s)
      Ryota Morimoto
    • Journal Title

      Journal of Cardiology

      Volume: 印刷中

    • Related Report
      2016 Research-status Report
    • Peer Reviewed
  • [Presentation] Dobutamine stress test as a predictor of left ventricular reverse2016

    • Author(s)
      Ryota Morimoto
    • Organizer
      欧州心臓病学会
    • Place of Presentation
      ローマ (イタリア)
    • Year and Date
      2016-08-27
    • Related Report
      2016 Research-status Report
    • Int'l Joint Research
  • [Funded Workshop] 欧州心臓病学会2016

    • Place of Presentation
      ローマ (イタリア)
    • Year and Date
      2016-08-26
    • Related Report
      2016 Research-status Report

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Published: 2016-04-21   Modified: 2020-03-30  

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