| Project/Area Number |
16K19402
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Cardiovascular medicine
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| Research Institution | Kyoto University |
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Principal Investigator |
MASAFUMI TAKEDA 京都大学, iPS細胞研究所, 研究員 (40547501)
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| Project Period (FY) |
2016-04-01 – 2018-03-31
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| Project Status |
Completed (Fiscal Year 2017)
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| Budget Amount *help |
¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000)
Fiscal Year 2017: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Fiscal Year 2016: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
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| Keywords | 心筋前駆細胞 / 心筋再生 / 再生 / 移植 / 再生医学 |
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| Outline of Final Research Achievements |
We successfully found that human-induced pluripotent stem cell (hiPSC)-derived cardiomyocyte (CM)-committed progenitors (CCPs) that express CD82, almost exclusively differentiate into CMs both in vitro and in vivo. Ｗe examined the effect of transplanted CD82+ CCPs to rat MI model. As a result, we observed transplanted CD82+ CCPs exclusively differentiated into CMs wihtin injured hearts and the beneficial effect on improving cardiac function. Although, unfortunately, we could not maintain and expand the CD82+ CCPs with the conbination of growth factors and singal inhibitors for maintaining and expanding cardiovasucular progenitors reported elsewhere, CD82+ CCPs should serve as a promising cells source for cardiac regeneration.
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