| Project/Area Number |
16K19408
|
|---|
| Research Category |
Grant-in-Aid for Young Scientists (B)
|
| Allocation Type | Multi-year Fund |
|---|
| Research Field |
Cardiovascular medicine
|
|---|
| Research Institution | Hiroshima University |
|---|
Principal Investigator |
|
|---|
| Research Collaborator |
HIGASHI Yukihito 広島大学, 原爆放射線医科学研究所, 教授
KIHARA Yasuki 広島大学, 大学院医歯薬保健学研究科, 教授
NOMA Kensuke 広島大学, 原爆放射線医科学研究所, 助教
NAKASHIMA Ayumu 広島大学, 大学院医歯薬保健学研究科, 共同研究講座教授
|
|---|
| Project Period (FY) |
2016-04-01 – 2018-03-31
|
| Project Status |
Completed (Fiscal Year 2017)
|
| Budget Amount *help |
¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000)
Fiscal Year 2017: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Fiscal Year 2016: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
|
|---|
| Keywords | 血管新生 / 間歇的圧迫 / 虚血性血管新生 / 下肢閉塞性動脈硬化症 |
|---|
| Outline of Final Research Achievements |
Exercise training has been demonstrated to improve exercise performance through promoting angiogenesis by inducing hypoxic response. The purpose of this study was to investigate whether external pneumatic intermittent compression promotes angiogenesis in a mouse ischemic limb model by inducing hypoxic response. Hindlimb ischemia was surgically induced by femoral artery ligation in wild type mice. Blood flow recovery after hindlimb ischemia was assessed by Laser Doppler blood perfusion index (LDPI). Capillary index (capillary/field) was assessed in the tissue sections from the ischemic hindlimb muscles. External pneumatic intermittent compression was applied (5 min×6/day) for consecutive 46 days. There was no significant difference in LDPI and capillary index between intermittent compression group and control group. These findings suggest that intermittent compression applied to ischemic limb was not effective in promoting angiogenesis in a mouse ischemic limb model.
|
