Unravelling of microvascular dysfunction after acute myocardial infarction

• Project/Area Number: 16K19420
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Multi-year Fund
• Research Field: Cardiovascular medicine
• Research Institution: Wakayama Medical University
• Principal Investigator: Ozaki Yuichi 和歌山県立医科大学, 医学部, 助教 (00507999)
• Research Collaborator: Nishiguchi Tsuyoshi ; Taruya Akira
• Project Period (FY): 2016-04-01 – 2019-03-31
• Project Status: Completed (Fiscal Year 2018)
• Budget Amount: ¥2,730,000 (Direct Cost: ¥2,100,000、Indirect Cost: ¥630,000); Fiscal Year 2017: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000); Fiscal Year 2016: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
• Keywords: acute coronary syndrome / 光干渉断層法 / monocyte / 急性冠症候群 / 光干渉断層装置 / 単球サブセット / 急性心筋梗塞 / 単球 / PSGL-1 / 循環器・高血圧

Outline of Final Research Achievements

In patients with acute coronary syndrome (ACS), the expression of PSGL-1 and TLR-4 on circulating peripheral CD14++CD16+ monocytes was significantly elevated, especially in patients with acute myocardial infarction. Moreover, the expression levels of PSGL-1 and TLR-4 on CD14++CD16+ monocytes were significantly higher in patients with plaque rupture or intra-coronary thrombus assessed by frequency-domain optical coherence tomography.
Up-regulation of PSGL-1 on CD14++CD16+ monocytes may be a crucial role in plaque rupture and thrombus formation in the setting of ACS.

Academic Significance and Societal Importance of the Research Achievements

今回の研究で急性冠症候群の発症において冠動脈プラーク破裂後の血栓形成と単球およびその細胞表面上に発現する特定の抗原との関係性を解明できた事で、今後の急性心筋梗塞を含めた急性冠症候群の治療戦略の発展に大きく影響すると考えられる。
また、この双方の関係性は急性冠症候群治療において急性期だけでなく慢性期の予後改善効果にも大きく貢献できる結果である。

Research Products

• [Journal Article] Exploring the use of intracoronary imaging devices such as optical coherence tomography (OCT) and intravascular ultrasound (IVUS), as a means of focusing on the prediction and prevention of coronary artery disease (2019)
  • Author(s): Yuichi Ozaki, Takashi Akasaka
  • Journal Title: Impact Volume: 2019 Issue: 2 Pages: 55-57
  • DOI: 10.21820/23987073.2019.2.55
  • Open Access
• [Journal Article] Association of Toll-Like Receptor 4 on Human Monocyte Subsets and Vulnerability Characteristics of Coronary Plaque as Assessed by 64-Slice Multidetector Computed Tomography (2017)
  • Author(s): Ozaki Y, Imanishi T, Hosokawa S, Nishiguchi T, Taruya A, Tanimoto T, Kuroi A, Yamano T, Matsuo Y, Ino Y, Kitabata H, Kubo T, Tanaka A, Akasaka T.
  • Journal Title: Circulation Journal Volume: 81 Issue: 6 Pages: 837-845
  • DOI: 10.1253/circj.CJ-16-0688
  • NAID: 130005679700
  • ISSN: 1346-9843, 1347-4820
  • Peer Reviewed / Open Access / Acknowledgement Compliant