| Budget Amount *help |
¥3,120,000 (Direct Cost: ¥2,400,000、Indirect Cost: ¥720,000)
Fiscal Year 2017: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2016: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
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| Outline of Final Research Achievements |
The aim of this study was to clarify the role of micro RNA within platelets.
Micro RNA within platelets decreased upon platelet aging and platelet activation. The quantity of RNA within platelets correlated with activation ability of the platelets. These results were observed both experiments using human platelets and experiments using mouse platelets. RNA poor platelets were increased inside the mouse having endothelial injury. From the database analysis, there is a possibility that the micro RNA decreasing by platelet activation affect the thrombus formation and inflammatory response.
Utilizing this micro RNA, we may able to establish a new therapeutic strategy that can control thrombotic reaction and inflammatory response. Quality check of transfusion platelets and risk assessment of thrombosis of individual patient becomes possible by quantifying RNA within platelets.
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