Elucidation of the molecular mechanism of hydrogen inhalation
| Project/Area Number |
16K19425
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Cardiovascular medicine
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| Research Institution | Keio University |
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Principal Investigator |
Goto Shinichi 慶應義塾大学, 医学部(信濃町), 助教 (50770864)
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| Project Period (FY) |
2016-04-01 – 2018-03-31
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| Project Status |
Completed (Fiscal Year 2017)
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| Budget Amount *help |
¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000)
Fiscal Year 2017: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2016: ¥2,730,000 (Direct Cost: ¥2,100,000、Indirect Cost: ¥630,000)
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| Keywords | 水素 / 吸入 / 脳梗塞 / 代謝 / 治療 / 酵素 / メカニズム |
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| Outline of Final Research Achievements |
To elucidate the molecular target of hydrogen, we compared multiple metabolites between stroke model mice treated with hydrogen inhalation or control. We have published a research paper on the utilization of this technology.
To elucidate how the hydrogen molecule reach the stroke area, we have performed computer simulation in combination with actual measurements of hydrogen in the brain. These results suggested simple diffusion of hydrogen gas. To confirm this finding, we measured the hydrogen concentration in locations with different distances from the air way in the brain. This did not give meaning full results mainly because the size of brain was too small in mice.
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Report
(3 results)
Research Products
(4 results)
